Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments

The immunosuppressive strategies devised by neuroblastoma (NB), the most common solid extracranial childhood cancer, are poorly understood. Here, we identified an immunoevasive program triggered by NB through secretion of galectin-1 (Gal-1), a multifunctional glycan-binding protein. Human and mouse...

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Detalles Bibliográficos
Autores principales: Soldati, R., Berger, E., Zenclussen, A.C., Jorch, G., Lode, H.N., Salatino, M., Rabinovich, G.A., Fest, S.
Formato: JOUR
Materias:
, tolerance
Dendritic cells
Galectin-1
Neuroblastoma
T cells
galectin 1
gamma interferon
animal cell
animal experiment
animal model
apoptosis
article
cancer inhibition
CD4+ T lymphocyte
CD8+ T lymphocyte
cell function
cell maturation
cell transfer
controlled study
cytotoxic T lymphocyte
dendritic cell
female
flow cytometry
gene silencing
human
human cell
immunohistochemistry
immunomodulation
immunoregulation
in vitro study
liver metastasis
lymphocyte migration
male
metastasis inhibition
mouse
neuroblastoma
nonhuman
priority journal
protein expression
protein secretion
T lymphocyte
tumor escape
Animals
Antigen-Presenting Cells
Apoptosis
Blotting, Western
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Adhesion
Cell Movement
Cell Proliferation
Dendritic Cells
Female
Flow Cytometry
Galectin 1
Genetic Therapy
Humans
Immunoenzyme Techniques
Interferon-gamma
Lung Neoplasms
Mice
Mice, Inbred A
T-Lymphocytes, Cytotoxic
Tumor Cells, Cultured
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00207136_v131_n5_p1131_Soldati
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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