Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action
1. 1. The action of hexachlorobenzene (HCB) on hepatic ferrochelatase was investigated. 2. 2. A direct action of HCB, pentachlorophenol, porphyrins and haem on this enzyme activity was discarded. 3. 3. In HCB porphyric liver there is probably an activator tightly bound to the enzyme. 4. 4. Pyridoxal...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0020711X_v23_n7-8_p669_RiosDeMolina |
| Aporte de: |
| id |
todo:paper_0020711X_v23_n7-8_p669_RiosDeMolina |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_0020711X_v23_n7-8_p669_RiosDeMolina2023-10-03T14:18:06Z Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action Ríos De Molina, M.D.C. De Catabbi, S.B. De Viale, L.C.S.M. ferrochelatase hexachlorobenzene pyridoxal 5 phosphate animal experiment animal model animal tissue article conformational transition drug mechanism drug toxicity liver nonhuman oral drug administration porphyria rat Animal Binding Sites Chromatography, Gel Copper Copper Sulfate Female Ferrochelatase Heat Heme Hexachlorobenzene Liver Pentachlorophenol Porphyria Porphyrins Protein Conformation Pyridoxal Phosphate Rats Rats, Inbred Strains Spectrophotometry Support, Non-U.S. Gov't Animalia 1. 1. The action of hexachlorobenzene (HCB) on hepatic ferrochelatase was investigated. 2. 2. A direct action of HCB, pentachlorophenol, porphyrins and haem on this enzyme activity was discarded. 3. 3. In HCB porphyric liver there is probably an activator tightly bound to the enzyme. 4. 4. Pyridoxal phosphate (PPL) may be a cofactor of ferrochelatase from both normal and porphyric rats. 5. 5. The PPL would be involved in the binding site of Fe2+ or at least in the approaching of Fe2+ to the active site of the enzyme. 6. 6. The differences found between normal and porphyric preparations could be attributed to conformational changes elicited by the HCB. © 1991. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0020711X_v23_n7-8_p669_RiosDeMolina |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
ferrochelatase hexachlorobenzene pyridoxal 5 phosphate animal experiment animal model animal tissue article conformational transition drug mechanism drug toxicity liver nonhuman oral drug administration porphyria rat Animal Binding Sites Chromatography, Gel Copper Copper Sulfate Female Ferrochelatase Heat Heme Hexachlorobenzene Liver Pentachlorophenol Porphyria Porphyrins Protein Conformation Pyridoxal Phosphate Rats Rats, Inbred Strains Spectrophotometry Support, Non-U.S. Gov't Animalia |
| spellingShingle |
ferrochelatase hexachlorobenzene pyridoxal 5 phosphate animal experiment animal model animal tissue article conformational transition drug mechanism drug toxicity liver nonhuman oral drug administration porphyria rat Animal Binding Sites Chromatography, Gel Copper Copper Sulfate Female Ferrochelatase Heat Heme Hexachlorobenzene Liver Pentachlorophenol Porphyria Porphyrins Protein Conformation Pyridoxal Phosphate Rats Rats, Inbred Strains Spectrophotometry Support, Non-U.S. Gov't Animalia Ríos De Molina, M.D.C. De Catabbi, S.B. De Viale, L.C.S.M. Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action |
| topic_facet |
ferrochelatase hexachlorobenzene pyridoxal 5 phosphate animal experiment animal model animal tissue article conformational transition drug mechanism drug toxicity liver nonhuman oral drug administration porphyria rat Animal Binding Sites Chromatography, Gel Copper Copper Sulfate Female Ferrochelatase Heat Heme Hexachlorobenzene Liver Pentachlorophenol Porphyria Porphyrins Protein Conformation Pyridoxal Phosphate Rats Rats, Inbred Strains Spectrophotometry Support, Non-U.S. Gov't Animalia |
| description |
1. 1. The action of hexachlorobenzene (HCB) on hepatic ferrochelatase was investigated. 2. 2. A direct action of HCB, pentachlorophenol, porphyrins and haem on this enzyme activity was discarded. 3. 3. In HCB porphyric liver there is probably an activator tightly bound to the enzyme. 4. 4. Pyridoxal phosphate (PPL) may be a cofactor of ferrochelatase from both normal and porphyric rats. 5. 5. The PPL would be involved in the binding site of Fe2+ or at least in the approaching of Fe2+ to the active site of the enzyme. 6. 6. The differences found between normal and porphyric preparations could be attributed to conformational changes elicited by the HCB. © 1991. |
| format |
JOUR |
| author |
Ríos De Molina, M.D.C. De Catabbi, S.B. De Viale, L.C.S.M. |
| author_facet |
Ríos De Molina, M.D.C. De Catabbi, S.B. De Viale, L.C.S.M. |
| author_sort |
Ríos De Molina, M.D.C. |
| title |
Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action |
| title_short |
Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action |
| title_full |
Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action |
| title_fullStr |
Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action |
| title_full_unstemmed |
Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action |
| title_sort |
liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action |
| url |
http://hdl.handle.net/20.500.12110/paper_0020711X_v23_n7-8_p669_RiosDeMolina |
| work_keys_str_mv |
AT riosdemolinamdc liverferrochelatasefromnormalandhexachlorobenzeneporphyricratsmechanismofdrugaction AT decatabbisb liverferrochelatasefromnormalandhexachlorobenzeneporphyricratsmechanismofdrugaction AT devialelcsm liverferrochelatasefromnormalandhexachlorobenzeneporphyricratsmechanismofdrugaction |
| _version_ |
1807315002766393344 |