Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins

Mostrar todas las versiones(3)

1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decr...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Del C. Batlle, A.M., De Salamanca, R.E., Chinarro, S., Afonso, S.G., Stella, A.M.
Formato: JOUR
Materias:
porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0020711X_v18_n2_p143_DelCBatlle
record_format dspace
spelling todo:paper_0020711X_v18_n2_p143_DelCBatlle2023-10-03T14:17:51Z Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins Del C. Batlle, A.M. De Salamanca, R.E. Chinarro, S. Afonso, S.G. Stella, A.M. porphyrin uroporphyrinogen decarboxylase blood and hemopoietic system enzyme inactivation erythrocyte human human cell photoactivation Carboxy-Lyases Erythrocytes Humans Kinetics Photolysis Porphyrins Thermodynamics Ultraviolet Rays Uroporphyrinogen Decarboxylase 1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986. Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
spellingShingle porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
Del C. Batlle, A.M.
De Salamanca, R.E.
Chinarro, S.
Afonso, S.G.
Stella, A.M.
Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
topic_facet porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
description 1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986.
format JOUR
author Del C. Batlle, A.M.
De Salamanca, R.E.
Chinarro, S.
Afonso, S.G.
Stella, A.M.
author_facet Del C. Batlle, A.M.
De Salamanca, R.E.
Chinarro, S.
Afonso, S.G.
Stella, A.M.
author_sort Del C. Batlle, A.M.
title Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_short Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_full Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_fullStr Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_full_unstemmed Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_sort photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
url http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle
work_keys_str_mv AT delcbatlleam photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins
AT desalamancare photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins
AT chinarros photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins
AT afonsosg photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins
AT stellaam photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins
_version_ 1782029477296996352

Ejemplares similares