Effect of cadmium on porphyrin biosynthesis-I
1. 1. Female Sprague-Dawley rats were exposed to Cd (50 ppm) administered in drinking water. 2. 2. The oral uptake of Cd did not alter δ-aminolevulinate and porphobilinogen urinary excretion nor the total content of daily porphyrin excretion in either urine or feces. 3. 3. A significant and consiste...
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todo:paper_0020711X_v12_n5-6_p905_EvaKesten2023-10-03T14:17:45Z Effect of cadmium on porphyrin biosynthesis-I Eva Kesten, M. Stella, A.M. Eva Wider De Xifra, A. Alcira Del Batlle, M.C. cadmium porphyrin animal experiment blood blood and hemopoietic system heavy metal poisoning kidney liver oral drug administration preliminary communication rat Aminolevulinic Acid Ammonia-Lyases Animal Cadmium Cadmium Poisoning Erythrocytes Feces Female Kidney Kinetics Liver Porphobilinogen Porphobilinogen Synthase Porphyrins Rats Support, Non-U.S. Gov't 1. 1. Female Sprague-Dawley rats were exposed to Cd (50 ppm) administered in drinking water. 2. 2. The oral uptake of Cd did not alter δ-aminolevulinate and porphobilinogen urinary excretion nor the total content of daily porphyrin excretion in either urine or feces. 3. 3. A significant and consistent difference in the composition of porphyrin in feces between control and Cd-exposed rats was observed. In the latter group a constant increase of coproporphyrin and a concomitant decrease in protoporphyrin was found. 4. 4. After 94 days exposure, Cd levels in blood and urine were low, and very high in kidney and liver. In red cells the activity of ALA-D was 40% reduced, and only a 20% decrease was observed for PBGase and deaminase. In kidney and liver ALA-D, PBGase and deaminase activities were the same in both control and Cd-intoxicated rats. 5. 5. It is suggested that determination of the ratio protoporphyrin:coproporphyrin in feces and ALA-D activity in red cells might be a biological index of Cd intoxication. © 1980. Fil:Eva Wider De Xifra, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alcira Del Batlle, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0020711X_v12_n5-6_p905_EvaKesten |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
cadmium porphyrin animal experiment blood blood and hemopoietic system heavy metal poisoning kidney liver oral drug administration preliminary communication rat Aminolevulinic Acid Ammonia-Lyases Animal Cadmium Cadmium Poisoning Erythrocytes Feces Female Kidney Kinetics Liver Porphobilinogen Porphobilinogen Synthase Porphyrins Rats Support, Non-U.S. Gov't |
| spellingShingle |
cadmium porphyrin animal experiment blood blood and hemopoietic system heavy metal poisoning kidney liver oral drug administration preliminary communication rat Aminolevulinic Acid Ammonia-Lyases Animal Cadmium Cadmium Poisoning Erythrocytes Feces Female Kidney Kinetics Liver Porphobilinogen Porphobilinogen Synthase Porphyrins Rats Support, Non-U.S. Gov't Eva Kesten, M. Stella, A.M. Eva Wider De Xifra, A. Alcira Del Batlle, M.C. Effect of cadmium on porphyrin biosynthesis-I |
| topic_facet |
cadmium porphyrin animal experiment blood blood and hemopoietic system heavy metal poisoning kidney liver oral drug administration preliminary communication rat Aminolevulinic Acid Ammonia-Lyases Animal Cadmium Cadmium Poisoning Erythrocytes Feces Female Kidney Kinetics Liver Porphobilinogen Porphobilinogen Synthase Porphyrins Rats Support, Non-U.S. Gov't |
| description |
1. 1. Female Sprague-Dawley rats were exposed to Cd (50 ppm) administered in drinking water. 2. 2. The oral uptake of Cd did not alter δ-aminolevulinate and porphobilinogen urinary excretion nor the total content of daily porphyrin excretion in either urine or feces. 3. 3. A significant and consistent difference in the composition of porphyrin in feces between control and Cd-exposed rats was observed. In the latter group a constant increase of coproporphyrin and a concomitant decrease in protoporphyrin was found. 4. 4. After 94 days exposure, Cd levels in blood and urine were low, and very high in kidney and liver. In red cells the activity of ALA-D was 40% reduced, and only a 20% decrease was observed for PBGase and deaminase. In kidney and liver ALA-D, PBGase and deaminase activities were the same in both control and Cd-intoxicated rats. 5. 5. It is suggested that determination of the ratio protoporphyrin:coproporphyrin in feces and ALA-D activity in red cells might be a biological index of Cd intoxication. © 1980. |
| format |
JOUR |
| author |
Eva Kesten, M. Stella, A.M. Eva Wider De Xifra, A. Alcira Del Batlle, M.C. |
| author_facet |
Eva Kesten, M. Stella, A.M. Eva Wider De Xifra, A. Alcira Del Batlle, M.C. |
| author_sort |
Eva Kesten, M. |
| title |
Effect of cadmium on porphyrin biosynthesis-I |
| title_short |
Effect of cadmium on porphyrin biosynthesis-I |
| title_full |
Effect of cadmium on porphyrin biosynthesis-I |
| title_fullStr |
Effect of cadmium on porphyrin biosynthesis-I |
| title_full_unstemmed |
Effect of cadmium on porphyrin biosynthesis-I |
| title_sort |
effect of cadmium on porphyrin biosynthesis-i |
| url |
http://hdl.handle.net/20.500.12110/paper_0020711X_v12_n5-6_p905_EvaKesten |
| work_keys_str_mv |
AT evakestenm effectofcadmiumonporphyrinbiosynthesisi AT stellaam effectofcadmiumonporphyrinbiosynthesisi AT evawiderdexifraa effectofcadmiumonporphyrinbiosynthesisi AT alciradelbatllemc effectofcadmiumonporphyrinbiosynthesisi |
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