The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections
Antibodies against the major cysteine proteinase (cruzipain) from Trypanosoma cruzi were detected in human sera obtained from patients with chronic Chagas' disease. Not only the intact 60-kDa enzyme but also its 25-kDa self-proteolysis fragment are antigenic in vivo. Although T. cruzi antigens...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00199567_v59_n11_p4275_Martinez |
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todo:paper_00199567_v59_n11_p4275_Martinez2023-10-03T14:16:35Z The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections Martinez, J. Campetella, O. Frasch, A.C.C. Cazzulo, J.J. antibody cysteine proteinase article chagas disease human tissue immunoblotting immunoreactivity nonhuman priority journal trypanosoma cruzi Animal Antibodies, Protozoan Antigens, Protozoan Blotting, Western Chagas Disease Cross Reactions Cysteine Endopeptidases Human Support, Non-U.S. Gov't Trypanosoma cruzi Antibodies against the major cysteine proteinase (cruzipain) from Trypanosoma cruzi were detected in human sera obtained from patients with chronic Chagas' disease. Not only the intact 60-kDa enzyme but also its 25-kDa self-proteolysis fragment are antigenic in vivo. Although T. cruzi antigens 13 and 36 also reacted with the apparently monospecific antiproteinase serum, the antigenicity of cruzipain to human patients is genuine, since its reactivity was not modified by the adsorption of human sera with the recombinant proteins 13 and 36. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00199567_v59_n11_p4275_Martinez |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
antibody cysteine proteinase article chagas disease human tissue immunoblotting immunoreactivity nonhuman priority journal trypanosoma cruzi Animal Antibodies, Protozoan Antigens, Protozoan Blotting, Western Chagas Disease Cross Reactions Cysteine Endopeptidases Human Support, Non-U.S. Gov't Trypanosoma cruzi |
| spellingShingle |
antibody cysteine proteinase article chagas disease human tissue immunoblotting immunoreactivity nonhuman priority journal trypanosoma cruzi Animal Antibodies, Protozoan Antigens, Protozoan Blotting, Western Chagas Disease Cross Reactions Cysteine Endopeptidases Human Support, Non-U.S. Gov't Trypanosoma cruzi Martinez, J. Campetella, O. Frasch, A.C.C. Cazzulo, J.J. The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections |
| topic_facet |
antibody cysteine proteinase article chagas disease human tissue immunoblotting immunoreactivity nonhuman priority journal trypanosoma cruzi Animal Antibodies, Protozoan Antigens, Protozoan Blotting, Western Chagas Disease Cross Reactions Cysteine Endopeptidases Human Support, Non-U.S. Gov't Trypanosoma cruzi |
| description |
Antibodies against the major cysteine proteinase (cruzipain) from Trypanosoma cruzi were detected in human sera obtained from patients with chronic Chagas' disease. Not only the intact 60-kDa enzyme but also its 25-kDa self-proteolysis fragment are antigenic in vivo. Although T. cruzi antigens 13 and 36 also reacted with the apparently monospecific antiproteinase serum, the antigenicity of cruzipain to human patients is genuine, since its reactivity was not modified by the adsorption of human sera with the recombinant proteins 13 and 36. |
| format |
JOUR |
| author |
Martinez, J. Campetella, O. Frasch, A.C.C. Cazzulo, J.J. |
| author_facet |
Martinez, J. Campetella, O. Frasch, A.C.C. Cazzulo, J.J. |
| author_sort |
Martinez, J. |
| title |
The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections |
| title_short |
The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections |
| title_full |
The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections |
| title_fullStr |
The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections |
| title_full_unstemmed |
The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections |
| title_sort |
major cysteine proteinase (cruzipain) from trypanosoma cruzi is antigenic in human infections |
| url |
http://hdl.handle.net/20.500.12110/paper_00199567_v59_n11_p4275_Martinez |
| work_keys_str_mv |
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1807315445913485312 |