Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells

The GnRH agonist leuprolide acetate (LA) inhibited DNA synthesis in epidermal growth factor-stimulated human granulosa luteinized cell cultures. This effect was blocked by the prior addition of a GnRH antagonist antide (ANT), and this compound per se was able to produce a stimulatory effect of DNA s...

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Autores principales: Vitale, A.M., Abramovich, D., Peluffo, M.C., Meresman, G., Tesone, M.
Formato: JOUR
Materias:
iturelix
leuprorelin
apoptosis
article
cell proliferation
DNA synthesis
drug antagonism
drug effect
granulosa cell
human
human cell
priority journal
Apoptosis
Cell Proliferation
Female
Gonadotropin-Releasing Hormone
Granulosa Cells
Humans
Leuprolide
Oligopeptides
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00150282_v85_n4_p1064_Vitale
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00150282_v85_n4_p1064_Vitale
record_format dspace
spelling todo:paper_00150282_v85_n4_p1064_Vitale2023-10-03T14:13:29Z Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells Vitale, A.M. Abramovich, D. Peluffo, M.C. Meresman, G. Tesone, M. iturelix leuprorelin apoptosis article cell proliferation DNA synthesis drug antagonism drug effect granulosa cell human human cell priority journal Apoptosis Cell Proliferation Female Gonadotropin-Releasing Hormone Granulosa Cells Humans Leuprolide Oligopeptides The GnRH agonist leuprolide acetate (LA) inhibited DNA synthesis in epidermal growth factor-stimulated human granulosa luteinized cell cultures. This effect was blocked by the prior addition of a GnRH antagonist antide (ANT), and this compound per se was able to produce a stimulatory effect of DNA synthesis on basal conditions. Leuprolide acetate produced an increase in the percentage of apoptotic cells, and when these two factors were co-incubated, ANT blocked the apoptotic effect produced by LA. ©2006 by American Society for Reproductive Medicine. Fil:Vitale, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Abramovich, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Peluffo, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tesone, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00150282_v85_n4_p1064_Vitale
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic iturelix
leuprorelin
apoptosis
article
cell proliferation
DNA synthesis
drug antagonism
drug effect
granulosa cell
human
human cell
priority journal
Apoptosis
Cell Proliferation
Female
Gonadotropin-Releasing Hormone
Granulosa Cells
Humans
Leuprolide
Oligopeptides
spellingShingle iturelix
leuprorelin
apoptosis
article
cell proliferation
DNA synthesis
drug antagonism
drug effect
granulosa cell
human
human cell
priority journal
Apoptosis
Cell Proliferation
Female
Gonadotropin-Releasing Hormone
Granulosa Cells
Humans
Leuprolide
Oligopeptides
Vitale, A.M.
Abramovich, D.
Peluffo, M.C.
Meresman, G.
Tesone, M.
Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
topic_facet iturelix
leuprorelin
apoptosis
article
cell proliferation
DNA synthesis
drug antagonism
drug effect
granulosa cell
human
human cell
priority journal
Apoptosis
Cell Proliferation
Female
Gonadotropin-Releasing Hormone
Granulosa Cells
Humans
Leuprolide
Oligopeptides
description The GnRH agonist leuprolide acetate (LA) inhibited DNA synthesis in epidermal growth factor-stimulated human granulosa luteinized cell cultures. This effect was blocked by the prior addition of a GnRH antagonist antide (ANT), and this compound per se was able to produce a stimulatory effect of DNA synthesis on basal conditions. Leuprolide acetate produced an increase in the percentage of apoptotic cells, and when these two factors were co-incubated, ANT blocked the apoptotic effect produced by LA. ©2006 by American Society for Reproductive Medicine.
format JOUR
author Vitale, A.M.
Abramovich, D.
Peluffo, M.C.
Meresman, G.
Tesone, M.
author_facet Vitale, A.M.
Abramovich, D.
Peluffo, M.C.
Meresman, G.
Tesone, M.
author_sort Vitale, A.M.
title Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
title_short Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
title_full Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
title_fullStr Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
title_full_unstemmed Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
title_sort effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
url http://hdl.handle.net/20.500.12110/paper_00150282_v85_n4_p1064_Vitale
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