Male immunologic infertility: Sperm performance on in vitro fertilization
Objective: To analyze sperm performance in a group of patients with male immunologic infertility treated with IVF-ET. Design: Retrospective clinical study. Setting: Patients attending a private IVF clinic. Patient(s): The study group comprised seven men with significant levels of surface-bound antis...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00150282_v68_n4_p675_VazquezLevin |
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todo:paper_00150282_v68_n4_p675_VazquezLevin2023-10-03T14:13:22Z Male immunologic infertility: Sperm performance on in vitro fertilization Vazquez-Levin, M.H. Notrica, J.A. De Fried, E.P. Antisperm antibodies Early embryonic development Human embryos Immunologic infertility In vitro fertilization Pregnancy rate sperm antibody adult article autoimmunity controlled study embryo development female female infertility fertilization fertilization in vitro human major clinical study male male infertility nidation pregnancy rate priority journal retrospective study treatment outcome Adult Autoantibodies Embryo Implantation Embryonic and Fetal Development Female Fertilization Fertilization in Vitro Humans Infertility, Male Male Pregnancy Pregnancy Outcome Pregnancy Rate Retrospective Studies Spermatozoa Objective: To analyze sperm performance in a group of patients with male immunologic infertility treated with IVF-ET. Design: Retrospective clinical study. Setting: Patients attending a private IVF clinic. Patient(s): The study group comprised seven men with significant levels of surface-bound antisperm antibodies treated in nine IVF cycles. The control group comprised nine couples with female tubal infertility and no indication of male factor infertility treated on the same cycle. Intervention(s): None. Main Outcome Measure(s): Fertilization rate, early embryonic development, implantation, and clinical pregnancy rate (PR). Result(s): Forty-six (44.2%) of 104 inseminated oocytes were fertilized in the study group compared with 65 (84.4%) of 77 in the control group, which was a significant difference. Surface-bound antisperm antibodies significantly inhibited early embryonic cleavage in the study group (13 [28.3%] of 46 embryos with at least 3 blastomeres) compared with the control group (41 [63.1%] of 65 embryos with at least 3 blastomeres). The percentage of good-quality embryos (grades 1 and 2) was similar in the study and control groups (71.7% and 78.5%, respectively). The percentage of poor-quality embryos (grade 4 and two pronuclei) was higher in the study group compared with the control group (13.9% versus 9.2%, respectively); however, the difference was not significant. The implantation rate and clinical PR were lower in the study group (3% and 11%, respectively) compared with the control group (9.5% and 44%, respectively), but the difference was not statistically significant. Conclusion(s): The fertilization rate and early embryonic cleavage of human embryos was found to be reduced significantly in patients with high levels of surface-bound antisperm antibodies. Moreover, embryonic quality and the PR may be compromised by the presence of significant levels of surface-bound antisperm antibodies. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00150282_v68_n4_p675_VazquezLevin |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antisperm antibodies Early embryonic development Human embryos Immunologic infertility In vitro fertilization Pregnancy rate sperm antibody adult article autoimmunity controlled study embryo development female female infertility fertilization fertilization in vitro human major clinical study male male infertility nidation pregnancy rate priority journal retrospective study treatment outcome Adult Autoantibodies Embryo Implantation Embryonic and Fetal Development Female Fertilization Fertilization in Vitro Humans Infertility, Male Male Pregnancy Pregnancy Outcome Pregnancy Rate Retrospective Studies Spermatozoa |
| spellingShingle |
Antisperm antibodies Early embryonic development Human embryos Immunologic infertility In vitro fertilization Pregnancy rate sperm antibody adult article autoimmunity controlled study embryo development female female infertility fertilization fertilization in vitro human major clinical study male male infertility nidation pregnancy rate priority journal retrospective study treatment outcome Adult Autoantibodies Embryo Implantation Embryonic and Fetal Development Female Fertilization Fertilization in Vitro Humans Infertility, Male Male Pregnancy Pregnancy Outcome Pregnancy Rate Retrospective Studies Spermatozoa Vazquez-Levin, M.H. Notrica, J.A. De Fried, E.P. Male immunologic infertility: Sperm performance on in vitro fertilization |
| topic_facet |
Antisperm antibodies Early embryonic development Human embryos Immunologic infertility In vitro fertilization Pregnancy rate sperm antibody adult article autoimmunity controlled study embryo development female female infertility fertilization fertilization in vitro human major clinical study male male infertility nidation pregnancy rate priority journal retrospective study treatment outcome Adult Autoantibodies Embryo Implantation Embryonic and Fetal Development Female Fertilization Fertilization in Vitro Humans Infertility, Male Male Pregnancy Pregnancy Outcome Pregnancy Rate Retrospective Studies Spermatozoa |
| description |
Objective: To analyze sperm performance in a group of patients with male immunologic infertility treated with IVF-ET. Design: Retrospective clinical study. Setting: Patients attending a private IVF clinic. Patient(s): The study group comprised seven men with significant levels of surface-bound antisperm antibodies treated in nine IVF cycles. The control group comprised nine couples with female tubal infertility and no indication of male factor infertility treated on the same cycle. Intervention(s): None. Main Outcome Measure(s): Fertilization rate, early embryonic development, implantation, and clinical pregnancy rate (PR). Result(s): Forty-six (44.2%) of 104 inseminated oocytes were fertilized in the study group compared with 65 (84.4%) of 77 in the control group, which was a significant difference. Surface-bound antisperm antibodies significantly inhibited early embryonic cleavage in the study group (13 [28.3%] of 46 embryos with at least 3 blastomeres) compared with the control group (41 [63.1%] of 65 embryos with at least 3 blastomeres). The percentage of good-quality embryos (grades 1 and 2) was similar in the study and control groups (71.7% and 78.5%, respectively). The percentage of poor-quality embryos (grade 4 and two pronuclei) was higher in the study group compared with the control group (13.9% versus 9.2%, respectively); however, the difference was not significant. The implantation rate and clinical PR were lower in the study group (3% and 11%, respectively) compared with the control group (9.5% and 44%, respectively), but the difference was not statistically significant. Conclusion(s): The fertilization rate and early embryonic cleavage of human embryos was found to be reduced significantly in patients with high levels of surface-bound antisperm antibodies. Moreover, embryonic quality and the PR may be compromised by the presence of significant levels of surface-bound antisperm antibodies. |
| format |
JOUR |
| author |
Vazquez-Levin, M.H. Notrica, J.A. De Fried, E.P. |
| author_facet |
Vazquez-Levin, M.H. Notrica, J.A. De Fried, E.P. |
| author_sort |
Vazquez-Levin, M.H. |
| title |
Male immunologic infertility: Sperm performance on in vitro fertilization |
| title_short |
Male immunologic infertility: Sperm performance on in vitro fertilization |
| title_full |
Male immunologic infertility: Sperm performance on in vitro fertilization |
| title_fullStr |
Male immunologic infertility: Sperm performance on in vitro fertilization |
| title_full_unstemmed |
Male immunologic infertility: Sperm performance on in vitro fertilization |
| title_sort |
male immunologic infertility: sperm performance on in vitro fertilization |
| url |
http://hdl.handle.net/20.500.12110/paper_00150282_v68_n4_p675_VazquezLevin |
| work_keys_str_mv |
AT vazquezlevinmh maleimmunologicinfertilityspermperformanceoninvitrofertilization AT notricaja maleimmunologicinfertilityspermperformanceoninvitrofertilization AT defriedep maleimmunologicinfertilityspermperformanceoninvitrofertilization |
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1782024675563405312 |