Chromatin, DNA structure and alternative splicing

Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin...

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Detalles Bibliográficos
Autores principales: Nieto Moreno, N., Giono, L.E., Cambindo Botto, A.E., Muñoz, M.J., Kornblihtt, A.R.
Formato: JOUR
Materias:
Alternative splicing
Chromatin structure
Non-B DNA
RNA polymerase II elongation
binding protein
cystic fibrosis transmembrane conductance regulator
DNA interacting protein
fibronectin
hemoglobin alpha chain
messenger RNA
protein bcl x
protein SRSF3
RNA polymerase II
serine arginine rich protein
transcription factor
unclassified drug
chromatin
DNA
alpha globin gene
alternative RNA splicing
base pairing
Bcl x gene
CFTR gene
chromatin structure
CpG island
DNA conformation
DNA methylation
DNA modification
DNA sequence
DNA structure
DNA template
DNA transcription
enzyme phosphorylation
exon
fibronectin gene
gene expression
genetic association
histone modification
human
intron
kinetics
nonhuman
nucleosome
priority journal
protein processing
Review
RNA processing
transcription elongation
transcription regulation
animal
chemistry
genetic transcription
genetics
Alternative Splicing
Animals
Chromatin
Humans
Transcription, Genetic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00145793_v589_n22_p3370_NietoMoreno
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin compaction. These may affect alternative splicing decisions by inducing pauses or decreasing elongation rate that change the time-window for splicing regulatory sequences to be recognized. Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non-B DNA conformations on the regulation of alternative splicing. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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