Chromatin, DNA structure and alternative splicing

Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin...

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Autores principales:	Nieto Moreno, N., Giono, L.E., Cambindo Botto, A.E., Muñoz, M.J., Kornblihtt, A.R.
Formato:	JOUR
Materias:	Alternative splicing Chromatin structure Non-B DNA RNA polymerase II elongation binding protein cystic fibrosis transmembrane conductance regulator DNA interacting protein fibronectin hemoglobin alpha chain messenger RNA protein bcl x protein SRSF3 RNA polymerase II serine arginine rich protein transcription factor unclassified drug chromatin DNA alpha globin gene alternative RNA splicing base pairing Bcl x gene CFTR gene chromatin structure CpG island DNA conformation DNA methylation DNA modification DNA sequence DNA structure DNA template DNA transcription enzyme phosphorylation exon fibronectin gene gene expression genetic association histone modification human intron kinetics nonhuman nucleosome priority journal protein processing Review RNA processing transcription elongation transcription regulation animal chemistry genetic transcription genetics Alternative Splicing Animals Chromatin Humans Transcription, Genetic
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00145793_v589_n22_p3370_NietoMoreno
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00145793_v589_n22_p3370_NietoMoreno
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spelling	todo:paper_00145793_v589_n22_p3370_NietoMoreno2023-10-03T14:13:12Z Chromatin, DNA structure and alternative splicing Nieto Moreno, N. Giono, L.E. Cambindo Botto, A.E. Muñoz, M.J. Kornblihtt, A.R. Alternative splicing Chromatin structure Non-B DNA RNA polymerase II elongation binding protein cystic fibrosis transmembrane conductance regulator DNA interacting protein fibronectin hemoglobin alpha chain messenger RNA protein bcl x protein SRSF3 RNA polymerase II serine arginine rich protein transcription factor unclassified drug chromatin DNA alpha globin gene alternative RNA splicing base pairing Bcl x gene CFTR gene chromatin structure CpG island DNA conformation DNA methylation DNA modification DNA sequence DNA structure DNA template DNA transcription enzyme phosphorylation exon fibronectin gene gene expression genetic association histone modification human intron kinetics nonhuman nucleosome priority journal protein processing Review RNA processing transcription elongation transcription regulation animal chemistry chromatin genetic transcription genetics Alternative Splicing Animals Chromatin DNA Humans Transcription, Genetic Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin compaction. These may affect alternative splicing decisions by inducing pauses or decreasing elongation rate that change the time-window for splicing regulatory sequences to be recognized. Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non-B DNA conformations on the regulation of alternative splicing. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Fil:Giono, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Muñoz, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00145793_v589_n22_p3370_NietoMoreno
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Alternative splicing Chromatin structure Non-B DNA RNA polymerase II elongation binding protein cystic fibrosis transmembrane conductance regulator DNA interacting protein fibronectin hemoglobin alpha chain messenger RNA protein bcl x protein SRSF3 RNA polymerase II serine arginine rich protein transcription factor unclassified drug chromatin DNA alpha globin gene alternative RNA splicing base pairing Bcl x gene CFTR gene chromatin structure CpG island DNA conformation DNA methylation DNA modification DNA sequence DNA structure DNA template DNA transcription enzyme phosphorylation exon fibronectin gene gene expression genetic association histone modification human intron kinetics nonhuman nucleosome priority journal protein processing Review RNA processing transcription elongation transcription regulation animal chemistry chromatin genetic transcription genetics Alternative Splicing Animals Chromatin DNA Humans Transcription, Genetic
spellingShingle	Alternative splicing Chromatin structure Non-B DNA RNA polymerase II elongation binding protein cystic fibrosis transmembrane conductance regulator DNA interacting protein fibronectin hemoglobin alpha chain messenger RNA protein bcl x protein SRSF3 RNA polymerase II serine arginine rich protein transcription factor unclassified drug chromatin DNA alpha globin gene alternative RNA splicing base pairing Bcl x gene CFTR gene chromatin structure CpG island DNA conformation DNA methylation DNA modification DNA sequence DNA structure DNA template DNA transcription enzyme phosphorylation exon fibronectin gene gene expression genetic association histone modification human intron kinetics nonhuman nucleosome priority journal protein processing Review RNA processing transcription elongation transcription regulation animal chemistry chromatin genetic transcription genetics Alternative Splicing Animals Chromatin DNA Humans Transcription, Genetic Nieto Moreno, N. Giono, L.E. Cambindo Botto, A.E. Muñoz, M.J. Kornblihtt, A.R. Chromatin, DNA structure and alternative splicing
topic_facet	Alternative splicing Chromatin structure Non-B DNA RNA polymerase II elongation binding protein cystic fibrosis transmembrane conductance regulator DNA interacting protein fibronectin hemoglobin alpha chain messenger RNA protein bcl x protein SRSF3 RNA polymerase II serine arginine rich protein transcription factor unclassified drug chromatin DNA alpha globin gene alternative RNA splicing base pairing Bcl x gene CFTR gene chromatin structure CpG island DNA conformation DNA methylation DNA modification DNA sequence DNA structure DNA template DNA transcription enzyme phosphorylation exon fibronectin gene gene expression genetic association histone modification human intron kinetics nonhuman nucleosome priority journal protein processing Review RNA processing transcription elongation transcription regulation animal chemistry chromatin genetic transcription genetics Alternative Splicing Animals Chromatin DNA Humans Transcription, Genetic
description	Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin compaction. These may affect alternative splicing decisions by inducing pauses or decreasing elongation rate that change the time-window for splicing regulatory sequences to be recognized. Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non-B DNA conformations on the regulation of alternative splicing. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
format	JOUR
author	Nieto Moreno, N. Giono, L.E. Cambindo Botto, A.E. Muñoz, M.J. Kornblihtt, A.R.
author_facet	Nieto Moreno, N. Giono, L.E. Cambindo Botto, A.E. Muñoz, M.J. Kornblihtt, A.R.
author_sort	Nieto Moreno, N.
title	Chromatin, DNA structure and alternative splicing
title_short	Chromatin, DNA structure and alternative splicing
title_full	Chromatin, DNA structure and alternative splicing
title_fullStr	Chromatin, DNA structure and alternative splicing
title_full_unstemmed	Chromatin, DNA structure and alternative splicing
title_sort	chromatin, dna structure and alternative splicing
url	http://hdl.handle.net/20.500.12110/paper_00145793_v589_n22_p3370_NietoMoreno
work_keys_str_mv	AT nietomorenon chromatindnastructureandalternativesplicing AT gionole chromatindnastructureandalternativesplicing AT cambindobottoae chromatindnastructureandalternativesplicing AT munozmj chromatindnastructureandalternativesplicing AT kornblihttar chromatindnastructureandalternativesplicing
_version_	1807317895236026368

Chromatin, DNA structure and alternative splicing

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