Spermidine is essential for normal proliferation of trypanosomatid protozoa

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Trypanosomatid parasites containing a metabolically unstable ornithine decarboxylase (ODC) are naturally resistant to high levels of α-difluoromethylornithine (DFMO) because this ODC inhibitor, though causing a drastic reduction of intracellular putrescine, elicits only a moderate decrease of the sp...

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Detalles Bibliográficos
Autores principales:	González, N.S., Huber, A., Algranati, I.D.
Formato:	JOUR
Materias:	Cyclohexylamine Polyamine Spermidine Spermidine synthase Trypanosomatid proliferation eflornithine eticyclidine ornithine decarboxylase putrescine spermidine article cell proliferation controlled study Crithidia fasciculata enzyme stability nonhuman priority journal protozoon Trypanosoma cruzi Animals Cyclohexylamines Eflornithine Enzyme Inhibitors Ornithine Decarboxylase Putrescine Spermidine Synthase Spermine Protozoa Trypanosomatidae
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00145793_v508_n3_p323_Gonzalez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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