Coordination between transcription and pre-mRNA processing
A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events....
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todo:paper_00145793_v498_n2-3_p179_Cramer2023-10-03T14:13:07Z Coordination between transcription and pre-mRNA processing Cramer, P. Srebrow, A. Kadener, S. Werbajh, S. De La Mata, M. Melen, G. Nogués, G. Kornblihtt, A.R. Carboxy-terminal domain Coupling mRNA processing RNA polymerase II messenger RNA RNA polymerase II capping phenomenon carboxy terminal sequence cell nucleus nonhuman phosphorylation polyadenylation priority journal promoter region RNA processing RNA splicing RNA transcription short survey spliceosome transcription regulation Humans Macromolecular Substances Models, Biological RNA Polymerase II RNA Precursors RNA Processing, Post-Transcriptional RNA Splicing Transcription, Genetic A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies. Fil:Cramer, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Srebrow, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kadener, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:De La Mata, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Melen, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Nogués, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00145793_v498_n2-3_p179_Cramer |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Carboxy-terminal domain Coupling mRNA processing RNA polymerase II messenger RNA RNA polymerase II capping phenomenon carboxy terminal sequence cell nucleus nonhuman phosphorylation polyadenylation priority journal promoter region RNA processing RNA splicing RNA transcription short survey spliceosome transcription regulation Humans Macromolecular Substances Models, Biological RNA Polymerase II RNA Precursors RNA Processing, Post-Transcriptional RNA Splicing Transcription, Genetic |
spellingShingle |
Carboxy-terminal domain Coupling mRNA processing RNA polymerase II messenger RNA RNA polymerase II capping phenomenon carboxy terminal sequence cell nucleus nonhuman phosphorylation polyadenylation priority journal promoter region RNA processing RNA splicing RNA transcription short survey spliceosome transcription regulation Humans Macromolecular Substances Models, Biological RNA Polymerase II RNA Precursors RNA Processing, Post-Transcriptional RNA Splicing Transcription, Genetic Cramer, P. Srebrow, A. Kadener, S. Werbajh, S. De La Mata, M. Melen, G. Nogués, G. Kornblihtt, A.R. Coordination between transcription and pre-mRNA processing |
topic_facet |
Carboxy-terminal domain Coupling mRNA processing RNA polymerase II messenger RNA RNA polymerase II capping phenomenon carboxy terminal sequence cell nucleus nonhuman phosphorylation polyadenylation priority journal promoter region RNA processing RNA splicing RNA transcription short survey spliceosome transcription regulation Humans Macromolecular Substances Models, Biological RNA Polymerase II RNA Precursors RNA Processing, Post-Transcriptional RNA Splicing Transcription, Genetic |
description |
A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies. |
format |
JOUR |
author |
Cramer, P. Srebrow, A. Kadener, S. Werbajh, S. De La Mata, M. Melen, G. Nogués, G. Kornblihtt, A.R. |
author_facet |
Cramer, P. Srebrow, A. Kadener, S. Werbajh, S. De La Mata, M. Melen, G. Nogués, G. Kornblihtt, A.R. |
author_sort |
Cramer, P. |
title |
Coordination between transcription and pre-mRNA processing |
title_short |
Coordination between transcription and pre-mRNA processing |
title_full |
Coordination between transcription and pre-mRNA processing |
title_fullStr |
Coordination between transcription and pre-mRNA processing |
title_full_unstemmed |
Coordination between transcription and pre-mRNA processing |
title_sort |
coordination between transcription and pre-mrna processing |
url |
http://hdl.handle.net/20.500.12110/paper_00145793_v498_n2-3_p179_Cramer |
work_keys_str_mv |
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1782026879076663296 |