Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells

Epidermal growth factor (EGF) induces fibronectin (FN) and FN mRNA in rat liver epithelial cells, under conditions where the factor also induces the cells to migrate. Newly synthesized protein is secreted into the medium and deposited as substratum-bound extracellular matrix. The levels of mRNA and...

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Autores principales:	Seebacher, T., Manske, M., Kornblihtt, A.R., Bade, E.G.
Formato:	JOUR
Materias:	(Rat liver epithelial cell) Cell migration Cellular fibronectin Epidermal growth factor Extracellular matrix Gene expression mRNA splicing variant cyclic amp dexamethasone epidermal growth factor fibronectin animal cell cell culture cell migration epithelium cell extracellular matrix gene expression liver epithelium nonhuman priority journal rat rna splicing Animal Cells, Cultured Cyclic AMP Dexamethasone Epidermal Growth Factor Epithelium Fibronectins Insulin Liver Rats Reference Values RNA Splicing RNA, Messenger
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00145793_v239_n1_p113_Seebacher
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00145793_v239_n1_p113_Seebacher
record_format	dspace
spelling	todo:paper_00145793_v239_n1_p113_Seebacher2023-10-03T14:12:57Z Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells Seebacher, T. Manske, M. Kornblihtt, A.R. Bade, E.G. (Rat liver epithelial cell) Cell migration Cellular fibronectin Epidermal growth factor Extracellular matrix Gene expression mRNA splicing variant cyclic amp dexamethasone epidermal growth factor fibronectin animal cell cell culture cell migration epithelium cell extracellular matrix gene expression liver epithelium nonhuman priority journal rat rna splicing Animal Cells, Cultured Cyclic AMP Dexamethasone Epidermal Growth Factor Epithelium Fibronectins Insulin Liver Rats Reference Values RNA Splicing RNA, Messenger Epidermal growth factor (EGF) induces fibronectin (FN) and FN mRNA in rat liver epithelial cells, under conditions where the factor also induces the cells to migrate. Newly synthesized protein is secreted into the medium and deposited as substratum-bound extracellular matrix. The levels of mRNA and the amount of protein synthesized are not influenced by cyclic AMP or dexamethasone, factors that have been found to modulate FN expression in other cells. However, the cells are sensitive to the factors, suggesting a cell-specific regulation. The EGF-induced RNA contains the sequences EIIIA and EIIIB characteristic of cellular fibronectin. © 1988. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00145793_v239_n1_p113_Seebacher
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	(Rat liver epithelial cell) Cell migration Cellular fibronectin Epidermal growth factor Extracellular matrix Gene expression mRNA splicing variant cyclic amp dexamethasone epidermal growth factor fibronectin animal cell cell culture cell migration epithelium cell extracellular matrix gene expression liver epithelium nonhuman priority journal rat rna splicing Animal Cells, Cultured Cyclic AMP Dexamethasone Epidermal Growth Factor Epithelium Fibronectins Insulin Liver Rats Reference Values RNA Splicing RNA, Messenger
spellingShingle	(Rat liver epithelial cell) Cell migration Cellular fibronectin Epidermal growth factor Extracellular matrix Gene expression mRNA splicing variant cyclic amp dexamethasone epidermal growth factor fibronectin animal cell cell culture cell migration epithelium cell extracellular matrix gene expression liver epithelium nonhuman priority journal rat rna splicing Animal Cells, Cultured Cyclic AMP Dexamethasone Epidermal Growth Factor Epithelium Fibronectins Insulin Liver Rats Reference Values RNA Splicing RNA, Messenger Seebacher, T. Manske, M. Kornblihtt, A.R. Bade, E.G. Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells
topic_facet	(Rat liver epithelial cell) Cell migration Cellular fibronectin Epidermal growth factor Extracellular matrix Gene expression mRNA splicing variant cyclic amp dexamethasone epidermal growth factor fibronectin animal cell cell culture cell migration epithelium cell extracellular matrix gene expression liver epithelium nonhuman priority journal rat rna splicing Animal Cells, Cultured Cyclic AMP Dexamethasone Epidermal Growth Factor Epithelium Fibronectins Insulin Liver Rats Reference Values RNA Splicing RNA, Messenger
description	Epidermal growth factor (EGF) induces fibronectin (FN) and FN mRNA in rat liver epithelial cells, under conditions where the factor also induces the cells to migrate. Newly synthesized protein is secreted into the medium and deposited as substratum-bound extracellular matrix. The levels of mRNA and the amount of protein synthesized are not influenced by cyclic AMP or dexamethasone, factors that have been found to modulate FN expression in other cells. However, the cells are sensitive to the factors, suggesting a cell-specific regulation. The EGF-induced RNA contains the sequences EIIIA and EIIIB characteristic of cellular fibronectin. © 1988.
format	JOUR
author	Seebacher, T. Manske, M. Kornblihtt, A.R. Bade, E.G.
author_facet	Seebacher, T. Manske, M. Kornblihtt, A.R. Bade, E.G.
author_sort	Seebacher, T.
title	Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells
title_short	Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells
title_full	Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells
title_fullStr	Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells
title_full_unstemmed	Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells
title_sort	cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic amp in rat liver epithelial cells
url	http://hdl.handle.net/20.500.12110/paper_00145793_v239_n1_p113_Seebacher
work_keys_str_mv	AT seebachert cellularfibronectinisinducedbyepidermalgrowthfactorbutnotbydexamethasoneorcyclicampinratliverepithelialcells AT manskem cellularfibronectinisinducedbyepidermalgrowthfactorbutnotbydexamethasoneorcyclicampinratliverepithelialcells AT kornblihttar cellularfibronectinisinducedbyepidermalgrowthfactorbutnotbydexamethasoneorcyclicampinratliverepithelialcells AT badeeg cellularfibronectinisinducedbyepidermalgrowthfactorbutnotbydexamethasoneorcyclicampinratliverepithelialcells
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Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells

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