Gamma band activity in the RAS-intracellular mechanisms

Gamma band activity participates in sensory perception, problem solving, and memory. This review considers recent evidence showing that cells in the reticular activating system (RAS) exhibit gamma band activity, and describes the intrinsic membrane properties behind such manifestation. Specifically,...

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Autores principales:	Garcia-Rill, E., Kezunovic, N., D'Onofrio, S., Luster, B., Hyde, J., Bisagno, V., Urbano, F.J.
Formato:	JOUR
Materias:	Arousal Calcium/calmodulin-dependent protein kinase II Cyclic adenosine monophosphate G-proteins Neuronal calcium sensor Schizophrenia calcium calcium channel P type calcium channel Q type guanine nucleotide binding protein calcium channel N type voltage-dependent calcium channel (P-Q type) ascending reticular activating system awareness brain function calcium cell level consciousness gamma band activity high frequency oscillation human memory consolidation pedunculopontine tegmental nucleus priority journal REM sleep REM sleep deprivation review schizophrenia thalamus parafascicular nucleus wakefulness animal biological model brain cortex cytology gamma rhythm mesencephalon reticular formation nerve cell physiology Animals Calcium Channels, N-Type Cerebral Cortex Gamma Rhythm Humans Midbrain Reticular Formation Models, Biological Neurons Sleep, REM
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00144819_v232_n5_p1509_GarciaRill
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00144819_v232_n5_p1509_GarciaRill
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spelling	todo:paper_00144819_v232_n5_p1509_GarciaRill2023-10-03T14:12:34Z Gamma band activity in the RAS-intracellular mechanisms Garcia-Rill, E. Kezunovic, N. D'Onofrio, S. Luster, B. Hyde, J. Bisagno, V. Urbano, F.J. Arousal Calcium/calmodulin-dependent protein kinase II Cyclic adenosine monophosphate G-proteins Neuronal calcium sensor Schizophrenia calcium calcium channel P type calcium channel Q type guanine nucleotide binding protein calcium channel N type voltage-dependent calcium channel (P-Q type) ascending reticular activating system awareness brain function calcium cell level consciousness gamma band activity high frequency oscillation human memory consolidation pedunculopontine tegmental nucleus priority journal REM sleep REM sleep deprivation review schizophrenia thalamus parafascicular nucleus wakefulness animal biological model brain cortex cytology gamma rhythm mesencephalon reticular formation nerve cell physiology Animals Calcium Channels, N-Type Cerebral Cortex Gamma Rhythm Humans Midbrain Reticular Formation Models, Biological Neurons Sleep, REM Gamma band activity participates in sensory perception, problem solving, and memory. This review considers recent evidence showing that cells in the reticular activating system (RAS) exhibit gamma band activity, and describes the intrinsic membrane properties behind such manifestation. Specifically, we discuss how cells in the mesopontine pedunculopontine nucleus, intralaminar parafascicular nucleus, and pontine SubCoeruleus nucleus dorsalis all fire in the gamma band range when maximally activated, but no higher. The mechanisms involve high-threshold, voltage-dependent P/Q-type calcium channels, or sodium-dependent subthreshold oscillations. Rather than participating in the temporal binding of sensory events as in the cortex, gamma band activity in the RAS may participate in the processes of preconscious awareness and provide the essential stream of information for the formulation of many of our actions. We address three necessary next steps resulting from these discoveries: an intracellular mechanism responsible for maintaining gamma band activity based on persistent G-protein activation, separate intracellular pathways that differentiate between gamma band activity during waking versus during REM sleep, and an intracellular mechanism responsible for the dysregulation in gamma band activity in schizophrenia. These findings open several promising research avenues that have not been thoroughly explored. What are the effects of sleep or REM sleep deprivation on these RAS mechanisms? Are these mechanisms involved in memory processing during waking and/or during REM sleep? Does gamma band processing differ during waking versus REM sleep after sleep or REM sleep deprivation? © 2013 Springer-Verlag. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00144819_v232_n5_p1509_GarciaRill
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Arousal Calcium/calmodulin-dependent protein kinase II Cyclic adenosine monophosphate G-proteins Neuronal calcium sensor Schizophrenia calcium calcium channel P type calcium channel Q type guanine nucleotide binding protein calcium channel N type voltage-dependent calcium channel (P-Q type) ascending reticular activating system awareness brain function calcium cell level consciousness gamma band activity high frequency oscillation human memory consolidation pedunculopontine tegmental nucleus priority journal REM sleep REM sleep deprivation review schizophrenia thalamus parafascicular nucleus wakefulness animal biological model brain cortex cytology gamma rhythm mesencephalon reticular formation nerve cell physiology Animals Calcium Channels, N-Type Cerebral Cortex Gamma Rhythm Humans Midbrain Reticular Formation Models, Biological Neurons Sleep, REM
spellingShingle	Arousal Calcium/calmodulin-dependent protein kinase II Cyclic adenosine monophosphate G-proteins Neuronal calcium sensor Schizophrenia calcium calcium channel P type calcium channel Q type guanine nucleotide binding protein calcium channel N type voltage-dependent calcium channel (P-Q type) ascending reticular activating system awareness brain function calcium cell level consciousness gamma band activity high frequency oscillation human memory consolidation pedunculopontine tegmental nucleus priority journal REM sleep REM sleep deprivation review schizophrenia thalamus parafascicular nucleus wakefulness animal biological model brain cortex cytology gamma rhythm mesencephalon reticular formation nerve cell physiology Animals Calcium Channels, N-Type Cerebral Cortex Gamma Rhythm Humans Midbrain Reticular Formation Models, Biological Neurons Sleep, REM Garcia-Rill, E. Kezunovic, N. D'Onofrio, S. Luster, B. Hyde, J. Bisagno, V. Urbano, F.J. Gamma band activity in the RAS-intracellular mechanisms
topic_facet	Arousal Calcium/calmodulin-dependent protein kinase II Cyclic adenosine monophosphate G-proteins Neuronal calcium sensor Schizophrenia calcium calcium channel P type calcium channel Q type guanine nucleotide binding protein calcium channel N type voltage-dependent calcium channel (P-Q type) ascending reticular activating system awareness brain function calcium cell level consciousness gamma band activity high frequency oscillation human memory consolidation pedunculopontine tegmental nucleus priority journal REM sleep REM sleep deprivation review schizophrenia thalamus parafascicular nucleus wakefulness animal biological model brain cortex cytology gamma rhythm mesencephalon reticular formation nerve cell physiology Animals Calcium Channels, N-Type Cerebral Cortex Gamma Rhythm Humans Midbrain Reticular Formation Models, Biological Neurons Sleep, REM
description	Gamma band activity participates in sensory perception, problem solving, and memory. This review considers recent evidence showing that cells in the reticular activating system (RAS) exhibit gamma band activity, and describes the intrinsic membrane properties behind such manifestation. Specifically, we discuss how cells in the mesopontine pedunculopontine nucleus, intralaminar parafascicular nucleus, and pontine SubCoeruleus nucleus dorsalis all fire in the gamma band range when maximally activated, but no higher. The mechanisms involve high-threshold, voltage-dependent P/Q-type calcium channels, or sodium-dependent subthreshold oscillations. Rather than participating in the temporal binding of sensory events as in the cortex, gamma band activity in the RAS may participate in the processes of preconscious awareness and provide the essential stream of information for the formulation of many of our actions. We address three necessary next steps resulting from these discoveries: an intracellular mechanism responsible for maintaining gamma band activity based on persistent G-protein activation, separate intracellular pathways that differentiate between gamma band activity during waking versus during REM sleep, and an intracellular mechanism responsible for the dysregulation in gamma band activity in schizophrenia. These findings open several promising research avenues that have not been thoroughly explored. What are the effects of sleep or REM sleep deprivation on these RAS mechanisms? Are these mechanisms involved in memory processing during waking and/or during REM sleep? Does gamma band processing differ during waking versus REM sleep after sleep or REM sleep deprivation? © 2013 Springer-Verlag.
format	JOUR
author	Garcia-Rill, E. Kezunovic, N. D'Onofrio, S. Luster, B. Hyde, J. Bisagno, V. Urbano, F.J.
author_facet	Garcia-Rill, E. Kezunovic, N. D'Onofrio, S. Luster, B. Hyde, J. Bisagno, V. Urbano, F.J.
author_sort	Garcia-Rill, E.
title	Gamma band activity in the RAS-intracellular mechanisms
title_short	Gamma band activity in the RAS-intracellular mechanisms
title_full	Gamma band activity in the RAS-intracellular mechanisms
title_fullStr	Gamma band activity in the RAS-intracellular mechanisms
title_full_unstemmed	Gamma band activity in the RAS-intracellular mechanisms
title_sort	gamma band activity in the ras-intracellular mechanisms
url	http://hdl.handle.net/20.500.12110/paper_00144819_v232_n5_p1509_GarciaRill
work_keys_str_mv	AT garciarille gammabandactivityintherasintracellularmechanisms AT kezunovicn gammabandactivityintherasintracellularmechanisms AT donofrios gammabandactivityintherasintracellularmechanisms AT lusterb gammabandactivityintherasintracellularmechanisms AT hydej gammabandactivityintherasintracellularmechanisms AT bisagnov gammabandactivityintherasintracellularmechanisms AT urbanofj gammabandactivityintherasintracellularmechanisms
_version_	1807314881993506816

Gamma band activity in the RAS-intracellular mechanisms

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