Effects of ACTH and diabetes on phospholipid metabolism in adrenal mitochondria

Incorporation of 32P into adrenal mitochondrial phospholipids (PL) increased in ACTH-treated rats, but it decreased in diabetics, inspite of the fact that these animals showed adrenal overactivity. Since diabetics did not show increased 11 β-hydroxylation, as opposed to ACTH-treated rats, it is sugg...

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Autores principales: De Nicola, A.F., Fridman, O., Foglia, V.G.
Formato: JOUR
Materias:
corticotropin
phospholipid
phosphorus 32
streptozocin
tetracosactide
adrenal gland
diabetes mellitus
gland
hydroxylation
in vitro study
membrane
mitochondrial membrane
mitochondrion
phosphate p 32
rat
Adrenal Cortex
Adrenal Glands
Animal
Corticotropin
Desoxycorticosterone
Diabetes Mellitus
Female
Mitochondria
Organ Weight
Phospholipids
Rats
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144754_v33_n7_p974_DeNicola
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00144754_v33_n7_p974_DeNicola
record_format dspace
spelling todo:paper_00144754_v33_n7_p974_DeNicola2023-10-03T14:12:22Z Effects of ACTH and diabetes on phospholipid metabolism in adrenal mitochondria De Nicola, A.F. Fridman, O. Foglia, V.G. corticotropin phospholipid phosphorus 32 streptozocin tetracosactide adrenal gland diabetes mellitus gland hydroxylation in vitro study membrane mitochondrial membrane mitochondrion phosphate p 32 rat Adrenal Cortex Adrenal Glands Animal Corticotropin Desoxycorticosterone Diabetes Mellitus Female Mitochondria Organ Weight Phospholipids Rats Incorporation of 32P into adrenal mitochondrial phospholipids (PL) increased in ACTH-treated rats, but it decreased in diabetics, inspite of the fact that these animals showed adrenal overactivity. Since diabetics did not show increased 11 β-hydroxylation, as opposed to ACTH-treated rats, it is suggested that the stimulation of this enzyme activity by exogenous ACTH is related to an increased turnover of PL at the mitochondrial membrane. This process is impaired in diabetics and prevents the stimulation of 11 β-hydroxylation. © 1977 Birkhäuser Verlag. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00144754_v33_n7_p974_DeNicola
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic corticotropin
phospholipid
phosphorus 32
streptozocin
tetracosactide
adrenal gland
diabetes mellitus
gland
hydroxylation
in vitro study
membrane
mitochondrial membrane
mitochondrion
phosphate p 32
rat
Adrenal Cortex
Adrenal Glands
Animal
Corticotropin
Desoxycorticosterone
Diabetes Mellitus
Female
Mitochondria
Organ Weight
Phospholipids
Rats
spellingShingle corticotropin
phospholipid
phosphorus 32
streptozocin
tetracosactide
adrenal gland
diabetes mellitus
gland
hydroxylation
in vitro study
membrane
mitochondrial membrane
mitochondrion
phosphate p 32
rat
Adrenal Cortex
Adrenal Glands
Animal
Corticotropin
Desoxycorticosterone
Diabetes Mellitus
Female
Mitochondria
Organ Weight
Phospholipids
Rats
De Nicola, A.F.
Fridman, O.
Foglia, V.G.
Effects of ACTH and diabetes on phospholipid metabolism in adrenal mitochondria
topic_facet corticotropin
phospholipid
phosphorus 32
streptozocin
tetracosactide
adrenal gland
diabetes mellitus
gland
hydroxylation
in vitro study
membrane
mitochondrial membrane
mitochondrion
phosphate p 32
rat
Adrenal Cortex
Adrenal Glands
Animal
Corticotropin
Desoxycorticosterone
Diabetes Mellitus
Female
Mitochondria
Organ Weight
Phospholipids
Rats
description Incorporation of 32P into adrenal mitochondrial phospholipids (PL) increased in ACTH-treated rats, but it decreased in diabetics, inspite of the fact that these animals showed adrenal overactivity. Since diabetics did not show increased 11 β-hydroxylation, as opposed to ACTH-treated rats, it is suggested that the stimulation of this enzyme activity by exogenous ACTH is related to an increased turnover of PL at the mitochondrial membrane. This process is impaired in diabetics and prevents the stimulation of 11 β-hydroxylation. © 1977 Birkhäuser Verlag.
format JOUR
author De Nicola, A.F.
Fridman, O.
Foglia, V.G.
author_facet De Nicola, A.F.
Fridman, O.
Foglia, V.G.
author_sort De Nicola, A.F.
title Effects of ACTH and diabetes on phospholipid metabolism in adrenal mitochondria
title_short Effects of ACTH and diabetes on phospholipid metabolism in adrenal mitochondria
title_full Effects of ACTH and diabetes on phospholipid metabolism in adrenal mitochondria
title_fullStr Effects of ACTH and diabetes on phospholipid metabolism in adrenal mitochondria
title_full_unstemmed Effects of ACTH and diabetes on phospholipid metabolism in adrenal mitochondria
title_sort effects of acth and diabetes on phospholipid metabolism in adrenal mitochondria
url http://hdl.handle.net/20.500.12110/paper_00144754_v33_n7_p974_DeNicola
work_keys_str_mv AT denicolaaf effectsofacthanddiabetesonphospholipidmetabolisminadrenalmitochondria
AT fridmano effectsofacthanddiabetesonphospholipidmetabolisminadrenalmitochondria
AT fogliavg effectsofacthanddiabetesonphospholipidmetabolisminadrenalmitochondria
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