Correlation between pregnanesteroid conformation, receptor affinity, and anti-natriuretic effect

The aim of this study was to correlate mineralocorticoid action and steroid structure. Inasmuch as Na+ retention follows a parabolic dose-response curve for most pregnanesteroids, the second-order coefficient of the function was used as a representative factor for this bipartite biological effect. T...

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Detalles Bibliográficos
Autores principales: Piwien-Pilipuk, G., Kanelakis, K.C., Galigniana, M.D.
Formato: JOUR
Materias:
Aldosterone
Mineralocorticoid receptor
Natriuresis
Steroid conformation
11beta,17beta dihydroxy 6 methyl 17alpha (1 propynyl)androsta 1,4,6 trien 3 one
functional group
ligand
mineralocorticoid receptor
pregnane derivative
pregnanesteroid
sodium ion
steroid
unclassified drug
animal cell
animal experiment
antidiuresis
article
binding affinity
concentration response
controlled study
correlation analysis
drug conformation
drug mechanism
drug receptor binding
drug structure
in vitro study
in vivo study
male
nonhuman
priority journal
sodium retention
animal
cell strain COS1
Cercopithecus
chemistry
dose response
drug effect
human
metabolism
natriuresis
physiology
protein binding
rat
Sprague Dawley rat
structure activity relation
Animals
Cercopithecus aethiops
COS Cells
Dose-Response Relationship, Drug
Humans
Male
Pregnanes
Protein Binding
Rats
Rats, Sprague-Dawley
Receptors, Mineralocorticoid
Structure-Activity Relationship
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00142999_v454_n2-3_p131_PiwienPilipuk
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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