Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy
Purpose: Single photon emission computed tomography (SPECT) is widely used to evaluate functional abnormalities during the epileptic event. Changes in regional cerebral blood flow (rCBF) are well defined in patients with temporal lobe epilepsy (TLE) undergoing surgical resection. Nonetheless, the in...
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todo:paper_00139580_v38_n9_p1011_Rabinowicz2023-10-03T14:11:43Z Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy Rabinowicz, A.L. Salas, E. Beserra, F. Leiguarda, R.C. Vazquez, S.E. Cerebral blood flow Diaschisis Temporal lobe epilepsy adult article brain blood flow case report complex partial seizure electroencephalogram epilepsy female human male neuropsychological test nuclear magnetic resonance imaging priority journal single photon emission computer tomography temporal lobe temporal lobe epilepsy Adult Cysteine Epilepsy, Complex Partial Epilepsy, Temporal Lobe Female Functional Laterality Humans Magnetic Resonance Imaging Male Organotechnetium Compounds Radiopharmaceuticals Regional Blood Flow Temporal Lobe Tomography, Emission-Computed, Single-Photon Purpose: Single photon emission computed tomography (SPECT) is widely used to evaluate functional abnormalities during the epileptic event. Changes in regional cerebral blood flow (rCBF) are well defined in patients with temporal lobe epilepsy (TLE) undergoing surgical resection. Nonetheless, the interpretation of ictal abnormalities in CBF beyond the temporal lobes has not been carefully addressed. Methods: We assessed 4 patients with pathologically proven unilateral TLE who had significant ipsilateral frontal hypoperfusion in ictal studies with no other abnormalities but chronic epilepsy accounting for such findings. Patients were assessed as candidates for surgery by interictal BEG. neuropsychological studies, brain magnetic resonance imaging, scalp electrode video-EEG monitoring, and ictal SPECT. Results: Characteristic hyperperfusion was evident over the temporal lobe ipsilateral to the EEG focus, with significant hypoperfusion over the frontal region in 3 patients. In patient 4, frontal hypoperfusion was not statistically significant. Conclusions: SPECT demonstrated relative rCBF changes beyond the epileptogenic zone in unilateral TLE. Our findings provide further insight into the pathophysiological changes underlying this condition. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00139580_v38_n9_p1011_Rabinowicz |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cerebral blood flow Diaschisis Temporal lobe epilepsy adult article brain blood flow case report complex partial seizure electroencephalogram epilepsy female human male neuropsychological test nuclear magnetic resonance imaging priority journal single photon emission computer tomography temporal lobe temporal lobe epilepsy Adult Cysteine Epilepsy, Complex Partial Epilepsy, Temporal Lobe Female Functional Laterality Humans Magnetic Resonance Imaging Male Organotechnetium Compounds Radiopharmaceuticals Regional Blood Flow Temporal Lobe Tomography, Emission-Computed, Single-Photon |
| spellingShingle |
Cerebral blood flow Diaschisis Temporal lobe epilepsy adult article brain blood flow case report complex partial seizure electroencephalogram epilepsy female human male neuropsychological test nuclear magnetic resonance imaging priority journal single photon emission computer tomography temporal lobe temporal lobe epilepsy Adult Cysteine Epilepsy, Complex Partial Epilepsy, Temporal Lobe Female Functional Laterality Humans Magnetic Resonance Imaging Male Organotechnetium Compounds Radiopharmaceuticals Regional Blood Flow Temporal Lobe Tomography, Emission-Computed, Single-Photon Rabinowicz, A.L. Salas, E. Beserra, F. Leiguarda, R.C. Vazquez, S.E. Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy |
| topic_facet |
Cerebral blood flow Diaschisis Temporal lobe epilepsy adult article brain blood flow case report complex partial seizure electroencephalogram epilepsy female human male neuropsychological test nuclear magnetic resonance imaging priority journal single photon emission computer tomography temporal lobe temporal lobe epilepsy Adult Cysteine Epilepsy, Complex Partial Epilepsy, Temporal Lobe Female Functional Laterality Humans Magnetic Resonance Imaging Male Organotechnetium Compounds Radiopharmaceuticals Regional Blood Flow Temporal Lobe Tomography, Emission-Computed, Single-Photon |
| description |
Purpose: Single photon emission computed tomography (SPECT) is widely used to evaluate functional abnormalities during the epileptic event. Changes in regional cerebral blood flow (rCBF) are well defined in patients with temporal lobe epilepsy (TLE) undergoing surgical resection. Nonetheless, the interpretation of ictal abnormalities in CBF beyond the temporal lobes has not been carefully addressed. Methods: We assessed 4 patients with pathologically proven unilateral TLE who had significant ipsilateral frontal hypoperfusion in ictal studies with no other abnormalities but chronic epilepsy accounting for such findings. Patients were assessed as candidates for surgery by interictal BEG. neuropsychological studies, brain magnetic resonance imaging, scalp electrode video-EEG monitoring, and ictal SPECT. Results: Characteristic hyperperfusion was evident over the temporal lobe ipsilateral to the EEG focus, with significant hypoperfusion over the frontal region in 3 patients. In patient 4, frontal hypoperfusion was not statistically significant. Conclusions: SPECT demonstrated relative rCBF changes beyond the epileptogenic zone in unilateral TLE. Our findings provide further insight into the pathophysiological changes underlying this condition. |
| format |
JOUR |
| author |
Rabinowicz, A.L. Salas, E. Beserra, F. Leiguarda, R.C. Vazquez, S.E. |
| author_facet |
Rabinowicz, A.L. Salas, E. Beserra, F. Leiguarda, R.C. Vazquez, S.E. |
| author_sort |
Rabinowicz, A.L. |
| title |
Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy |
| title_short |
Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy |
| title_full |
Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy |
| title_fullStr |
Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy |
| title_full_unstemmed |
Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy |
| title_sort |
changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy |
| url |
http://hdl.handle.net/20.500.12110/paper_00139580_v38_n9_p1011_Rabinowicz |
| work_keys_str_mv |
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| _version_ |
1807318377349251072 |