Long-term intracerebroventricular corticotropin-releasing hormone administration induces distinct changes in rat splenocyte activation and cytokine expression

The effects of long-term corticotropin-releasing hormone (CRH) infusion in the lateral ventricle of the rat on hypothalamic-pituitary-adrenocortical (HPA) axis parameters and on the immune system function were studied. Compared with infusion of vehicle, the CRH treatment produced a sustained overact...

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Detalles Bibliográficos
Autores principales: Labeur, M.S., Arzt, E., Wiegers, G.J., Holsboer, F., Reul, J.M.H.M.
Formato: JOUR
Materias:
concanavalin a
corticosterone
corticotropin
corticotropin releasing factor
cytokine
interleukin 1beta
interleukin 2
interleukin 2 receptor
lipopolysaccharide
messenger rna
proopiomelanocortin
animal cell
animal experiment
article
b lymphocyte
corticotropin blood level
gene expression
hypothalamus hypophysis adrenal system
immune system
intracerebroventricular drug administration
lateral brain ventricle
lymphocyte proliferation
nonhuman
priority journal
rat
spleen cell
t lymphocyte
weight gain
Animal
B-Lymphocytes
Corticotropin-Releasing Hormone
Cytokines
Human
Hypothalamo-Hypophyseal System
In Vitro
Injections, Intraventricular
Interleukin-1
Interleukin-2
Lymphocyte Activation
Male
Neuroimmunomodulation
Pituitary-Adrenal System
Rats
Rats, Wistar
Receptors, Interleukin-2
RNA, Messenger
Support, Non-U.S. Gov't
T-Lymphocytes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00137227_v136_n6_p2678_Labeur
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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