Electrochemical treatment of tumors using a one-probe two-electrode device

We have recently shown that in the classical electrochemical treatment (EChT) of tumors, i.e., the passage of a direct electric current through two electrodes inserted locally in the tumor tissue, from an initial uniform condition two pH fronts evolve, expanding towards each other, inducing extreme...

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Autores principales: Olaiz, N., Maglietti, F., Suárez, C., Molina, F.V., Miklavcic, D., Mir, L., Marshall, G.
Formato: JOUR
Materias:
Electrochemical treatment
Electrochemotherapy
In vitro models
PH front tracking
Tumors
Electrochemical treatments
Front tracking
In-vitro
Electric current measurement
Electric power supplies to apparatus
Optimization
Spheres
Electrochemical electrodes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00134686_v55_n20_p6010_Olaiz
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00134686_v55_n20_p6010_Olaiz
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spelling todo:paper_00134686_v55_n20_p6010_Olaiz2023-10-03T14:11:03Z Electrochemical treatment of tumors using a one-probe two-electrode device Olaiz, N. Maglietti, F. Suárez, C. Molina, F.V. Miklavcic, D. Mir, L. Marshall, G. Electrochemical treatment Electrochemotherapy In vitro models PH front tracking Tumors Electrochemical treatments Electrochemotherapy Front tracking In vitro models In-vitro Electric current measurement Electric power supplies to apparatus Optimization Spheres Tumors Electrochemical electrodes We have recently shown that in the classical electrochemical treatment (EChT) of tumors, i.e., the passage of a direct electric current through two electrodes inserted locally in the tumor tissue, from an initial uniform condition two pH fronts evolve, expanding towards each other, inducing extreme pH changes and tumor destruction, mainly by necrosis. Here we extend these results introducing a oneprobe two-electrode device (OPTED) containing the cathode and the anode very close to each other (1 mm). Experiments show that upon application of the OPTED-EChT, two half-spherical pH fronts, one basic and the other acid (from cathode and anode, respectively), expand towards the periphery configuring a distorted full sphere. Tracking of the pH front advance reveals a time scaling close to t1/2, signature of a diffusion-controlled process. An analytic model presented allows the estimation of the time needed for total tumor destruction with a minimum compromise of healthy tissue. Main advantages of the OPTED are the insertion of one applicator rather than two or more (thus minimizing tissue intrusion, for instance, in the nervous system), the ability to reach tumors beyond capabilities of conventional surgery and the minimization of electric current circulation through the treated organ. We propose here this new design which could have significant implications in EChT optimal operative conditions, in particular, in the way in which the evolving pH spherical fronts can cover and destroy a cancer cell spherical casket. © 2010 Elsevier Ltd. All rights reserved. Fil:Suárez, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Molina, F.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00134686_v55_n20_p6010_Olaiz
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Electrochemical treatment
Electrochemotherapy
In vitro models
PH front tracking
Tumors
Electrochemical treatments
Electrochemotherapy
Front tracking
In vitro models
In-vitro
Electric current measurement
Electric power supplies to apparatus
Optimization
Spheres
Tumors
Electrochemical electrodes
spellingShingle Electrochemical treatment
Electrochemotherapy
In vitro models
PH front tracking
Tumors
Electrochemical treatments
Electrochemotherapy
Front tracking
In vitro models
In-vitro
Electric current measurement
Electric power supplies to apparatus
Optimization
Spheres
Tumors
Electrochemical electrodes
Olaiz, N.
Maglietti, F.
Suárez, C.
Molina, F.V.
Miklavcic, D.
Mir, L.
Marshall, G.
Electrochemical treatment of tumors using a one-probe two-electrode device
topic_facet Electrochemical treatment
Electrochemotherapy
In vitro models
PH front tracking
Tumors
Electrochemical treatments
Electrochemotherapy
Front tracking
In vitro models
In-vitro
Electric current measurement
Electric power supplies to apparatus
Optimization
Spheres
Tumors
Electrochemical electrodes
description We have recently shown that in the classical electrochemical treatment (EChT) of tumors, i.e., the passage of a direct electric current through two electrodes inserted locally in the tumor tissue, from an initial uniform condition two pH fronts evolve, expanding towards each other, inducing extreme pH changes and tumor destruction, mainly by necrosis. Here we extend these results introducing a oneprobe two-electrode device (OPTED) containing the cathode and the anode very close to each other (1 mm). Experiments show that upon application of the OPTED-EChT, two half-spherical pH fronts, one basic and the other acid (from cathode and anode, respectively), expand towards the periphery configuring a distorted full sphere. Tracking of the pH front advance reveals a time scaling close to t1/2, signature of a diffusion-controlled process. An analytic model presented allows the estimation of the time needed for total tumor destruction with a minimum compromise of healthy tissue. Main advantages of the OPTED are the insertion of one applicator rather than two or more (thus minimizing tissue intrusion, for instance, in the nervous system), the ability to reach tumors beyond capabilities of conventional surgery and the minimization of electric current circulation through the treated organ. We propose here this new design which could have significant implications in EChT optimal operative conditions, in particular, in the way in which the evolving pH spherical fronts can cover and destroy a cancer cell spherical casket. © 2010 Elsevier Ltd. All rights reserved.
format JOUR
author Olaiz, N.
Maglietti, F.
Suárez, C.
Molina, F.V.
Miklavcic, D.
Mir, L.
Marshall, G.
author_facet Olaiz, N.
Maglietti, F.
Suárez, C.
Molina, F.V.
Miklavcic, D.
Mir, L.
Marshall, G.
author_sort Olaiz, N.
title Electrochemical treatment of tumors using a one-probe two-electrode device
title_short Electrochemical treatment of tumors using a one-probe two-electrode device
title_full Electrochemical treatment of tumors using a one-probe two-electrode device
title_fullStr Electrochemical treatment of tumors using a one-probe two-electrode device
title_full_unstemmed Electrochemical treatment of tumors using a one-probe two-electrode device
title_sort electrochemical treatment of tumors using a one-probe two-electrode device
url http://hdl.handle.net/20.500.12110/paper_00134686_v55_n20_p6010_Olaiz
work_keys_str_mv AT olaizn electrochemicaltreatmentoftumorsusingaoneprobetwoelectrodedevice
AT magliettif electrochemicaltreatmentoftumorsusingaoneprobetwoelectrodedevice
AT suarezc electrochemicaltreatmentoftumorsusingaoneprobetwoelectrodedevice
AT molinafv electrochemicaltreatmentoftumorsusingaoneprobetwoelectrodedevice
AT miklavcicd electrochemicaltreatmentoftumorsusingaoneprobetwoelectrodedevice
AT mirl electrochemicaltreatmentoftumorsusingaoneprobetwoelectrodedevice
AT marshallg electrochemicaltreatmentoftumorsusingaoneprobetwoelectrodedevice
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