Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device

Electrolytic ablation (EA), a medical treatment used in solid tumor ablation due to its minimum side effects and low cost, consists in the passage of a low constant electric current through two or more electrodes inserted in the tissue thus inducing pH fronts that produce tumor necrosis. Combined wi...

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Detalles Bibliográficos
Autores principales: Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P., Marshall, G.
Formato: JOUR
Materias:
Electrochemical treatment
Electrolytic ablation
in silico models
in vitro models
pH front tracking
Tumors
Ablation
Electrodes
Probes
Tissue
Dose response relationships
Electrochemical reactions
Electrochemical treatments
Front tracking
In-silico models
In-vitro models
Minimally invasive treatments
Non-linear relationships
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00134686_v186_n_p494_Lujan
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Electrolytic ablation (EA), a medical treatment used in solid tumor ablation due to its minimum side effects and low cost, consists in the passage of a low constant electric current through two or more electrodes inserted in the tissue thus inducing pH fronts that produce tumor necrosis. Combined with a recently introduced one-probe two electrode device (OPTED) this procedure results in a minimally invasive treatment. Despite its success, EA has drawbacks such as the difficulties in determining the optimum dose-response relationship between the applied current, treatment time and necrotized tumor volume (NTV) and choosing a reliable dose parameter. In this work, a theoretical model is introduced describing the EA/OPTED as an electrolytic process and the underlying electrochemical reactions through the Nernst-Planck equations for ion transport. Model results show that the coulomb dosage is a reliable dose parameter and predicts an optimal dose-response relationship for a given tumor size subjected to an EA/OPTED, considering the optimum as the minimum coulomb dosage necessary to achieve total tumor destruction while minimizing healthy tissue damage. Moreover, it predicts a nonlinear relationship between coulomb dosage and NTV, dosage and NTV scaling as Q1.4. Consequently, these results could have a significant impact on dose planning methodology aimed at improving the effectiveness of the electrolytic ablation. © 2015 Elsevier Ltd.

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