Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs
The present study was aimed at determining the generation of 'prostacyclin (PGI2)-like-material' in coronary arteries from normal and diabetic (pancreatectomized) dogs as well as the contractile responses to prostacyclin of preparations from normal, diabetic and insulin-treated diabetic an...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0012186X_v22_n1_p56_SterinBorda |
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todo:paper_0012186X_v22_n1_p56_SterinBorda2023-10-03T14:10:19Z Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs Sterin-Borda, L. Borda, E.S. Gimeno, M.F. Lazzari, M.A. del Castillo, E. Gimeno, A.L. coronary constriction coronary relaxation diabetes Isolated coronary arteries pancreatectomized dogs PGI2 generation prostacyclin haloperidol insulin phentolamine phentolamine mesylate prostacyclin animal experiment coronary artery diabetes mellitus dog endocrine system heart in vitro study pancreas pancreas resection peripheral vascular system smooth muscle contractility vascular smooth muscle Animals Coronary Vessels Diabetes Mellitus, Experimental Dogs Dose-Response Relationship, Drug Epoprostenol Pancreatectomy Prostaglandins Vasoconstriction The present study was aimed at determining the generation of 'prostacyclin (PGI2)-like-material' in coronary arteries from normal and diabetic (pancreatectomized) dogs as well as the contractile responses to prostacyclin of preparations from normal, diabetic and insulin-treated diabetic animals. PGI2 produced a dose-dependent relaxation of coronary arteries from normal dogs. In contrast, those from diabetic animals were not relaxed; indeed, at low concentrations PGI2 failed to evoke any effect but at higher ones it induced a distinct contraction. In arteries from diabetic animals treated with insulin, PGI2 induced a biphasic contractile effect, which lay between that of normal controls and untreated diabetics. In addition the basal generation of 'PGI2-like-material' by coronary arteries was significantly higher in the diabetic (141±0.2 pg/mg, mean±SEM) than in normal dogs (59±0.2 pg/mg). The present experiments demonstrate that the generation of 'PGI2-like-substance' is significantly increased in coronary arteries from diabetic dogs, but the same vessels are unable to respond to added authentic PGI2 with relaxation; on the contrary they react with a distinct positive contractile response. © 1982 Springer-Verlag. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0012186X_v22_n1_p56_SterinBorda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
coronary constriction coronary relaxation diabetes Isolated coronary arteries pancreatectomized dogs PGI2 generation prostacyclin haloperidol insulin phentolamine phentolamine mesylate prostacyclin animal experiment coronary artery diabetes mellitus dog endocrine system heart in vitro study pancreas pancreas resection peripheral vascular system smooth muscle contractility vascular smooth muscle Animals Coronary Vessels Diabetes Mellitus, Experimental Dogs Dose-Response Relationship, Drug Epoprostenol Pancreatectomy Prostaglandins Vasoconstriction |
| spellingShingle |
coronary constriction coronary relaxation diabetes Isolated coronary arteries pancreatectomized dogs PGI2 generation prostacyclin haloperidol insulin phentolamine phentolamine mesylate prostacyclin animal experiment coronary artery diabetes mellitus dog endocrine system heart in vitro study pancreas pancreas resection peripheral vascular system smooth muscle contractility vascular smooth muscle Animals Coronary Vessels Diabetes Mellitus, Experimental Dogs Dose-Response Relationship, Drug Epoprostenol Pancreatectomy Prostaglandins Vasoconstriction Sterin-Borda, L. Borda, E.S. Gimeno, M.F. Lazzari, M.A. del Castillo, E. Gimeno, A.L. Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs |
| topic_facet |
coronary constriction coronary relaxation diabetes Isolated coronary arteries pancreatectomized dogs PGI2 generation prostacyclin haloperidol insulin phentolamine phentolamine mesylate prostacyclin animal experiment coronary artery diabetes mellitus dog endocrine system heart in vitro study pancreas pancreas resection peripheral vascular system smooth muscle contractility vascular smooth muscle Animals Coronary Vessels Diabetes Mellitus, Experimental Dogs Dose-Response Relationship, Drug Epoprostenol Pancreatectomy Prostaglandins Vasoconstriction |
| description |
The present study was aimed at determining the generation of 'prostacyclin (PGI2)-like-material' in coronary arteries from normal and diabetic (pancreatectomized) dogs as well as the contractile responses to prostacyclin of preparations from normal, diabetic and insulin-treated diabetic animals. PGI2 produced a dose-dependent relaxation of coronary arteries from normal dogs. In contrast, those from diabetic animals were not relaxed; indeed, at low concentrations PGI2 failed to evoke any effect but at higher ones it induced a distinct contraction. In arteries from diabetic animals treated with insulin, PGI2 induced a biphasic contractile effect, which lay between that of normal controls and untreated diabetics. In addition the basal generation of 'PGI2-like-material' by coronary arteries was significantly higher in the diabetic (141±0.2 pg/mg, mean±SEM) than in normal dogs (59±0.2 pg/mg). The present experiments demonstrate that the generation of 'PGI2-like-substance' is significantly increased in coronary arteries from diabetic dogs, but the same vessels are unable to respond to added authentic PGI2 with relaxation; on the contrary they react with a distinct positive contractile response. © 1982 Springer-Verlag. |
| format |
JOUR |
| author |
Sterin-Borda, L. Borda, E.S. Gimeno, M.F. Lazzari, M.A. del Castillo, E. Gimeno, A.L. |
| author_facet |
Sterin-Borda, L. Borda, E.S. Gimeno, M.F. Lazzari, M.A. del Castillo, E. Gimeno, A.L. |
| author_sort |
Sterin-Borda, L. |
| title |
Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs |
| title_short |
Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs |
| title_full |
Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs |
| title_fullStr |
Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs |
| title_full_unstemmed |
Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs |
| title_sort |
contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs |
| url |
http://hdl.handle.net/20.500.12110/paper_0012186X_v22_n1_p56_SterinBorda |
| work_keys_str_mv |
AT sterinbordal contractileactivityandprostacyclingenerationinisolatedcoronaryarteriesfromdiabeticdogs AT bordaes contractileactivityandprostacyclingenerationinisolatedcoronaryarteriesfromdiabeticdogs AT gimenomf contractileactivityandprostacyclingenerationinisolatedcoronaryarteriesfromdiabeticdogs AT lazzarima contractileactivityandprostacyclingenerationinisolatedcoronaryarteriesfromdiabeticdogs AT delcastilloe contractileactivityandprostacyclingenerationinisolatedcoronaryarteriesfromdiabeticdogs AT gimenoal contractileactivityandprostacyclingenerationinisolatedcoronaryarteriesfromdiabeticdogs |
| _version_ |
1807315573524135936 |