Tamm-Horsfall protein excretion to predict the onset of renal insufficiency
Objective: Immunosuppressive therapy after liver transplantation may be a risk for kidney dysfunction. This work was designed to determine whether Tamm-Horsfall Protein (THP) could be considered as a marker for nephrotoxicity. Design and Methods: THP was determined by an ELISA method in serial 24-h...
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todo:paper_00099120_v35_n1_p65_Romero2023-10-03T14:08:51Z Tamm-Horsfall protein excretion to predict the onset of renal insufficiency Romero, M.C. Zanaro, N. González, L. Trigo, P. Imventarza, O. Nesse, A. Biochemical markers Immunotherapy Liver transplantation Nephrotoxicity Renal insufficiency Tamm-Horsfall Protein creatinine Tamm Horsfall glycoprotein adult aged article clinical article controlled study creatinine blood level disease marker enzyme linked immunosorbent assay female human kidney failure liver transplantation male prediction priority journal protein secretion protein synthesis urinalysis urinary excretion Adolescent Adult Aged Biological Markers Creatinine Female Humans Immunoassay Kidney Kidney Failure Kidney Transplantation Male Middle Aged Mucoproteins Time Factors Objective: Immunosuppressive therapy after liver transplantation may be a risk for kidney dysfunction. This work was designed to determine whether Tamm-Horsfall Protein (THP) could be considered as a marker for nephrotoxicity. Design and Methods: THP was determined by an ELISA method in serial 24-h urine from liver transplant patients. Fourteen patients suffered renal insufficiency (LTr1) and 20 showed no acute renal damage (LTr2) after liver transplantation. Results: No clear association could be seen between daily THP excretion and plasma creatinine levels by comparing serial samples collected at the same time. Nevertheless, significant differences were observed in pretransplant THP excretion between both groups of patients. The results (Median/Interquartile Range) were: Controls: 113.2/84.9 to 146.8 mg/24 h (n = 30); LTr1: 36.9/18.3 to 54.5 mg/24 h (p≪0.001 with respect to C and LTr2); LTr2: 90.8/61.5 to 139.7 mg/24 h. Conclusions: The higher pretransplant synthesis and/or secretion of THP seem to have a protective role on the kidney during and after liver transplantation. © 2002 The Canadian Society of Clinical Chemists. All rights reserved. Fil:Nesse, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00099120_v35_n1_p65_Romero |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Biochemical markers Immunotherapy Liver transplantation Nephrotoxicity Renal insufficiency Tamm-Horsfall Protein creatinine Tamm Horsfall glycoprotein adult aged article clinical article controlled study creatinine blood level disease marker enzyme linked immunosorbent assay female human kidney failure liver transplantation male prediction priority journal protein secretion protein synthesis urinalysis urinary excretion Adolescent Adult Aged Biological Markers Creatinine Female Humans Immunoassay Kidney Kidney Failure Kidney Transplantation Male Middle Aged Mucoproteins Time Factors |
spellingShingle |
Biochemical markers Immunotherapy Liver transplantation Nephrotoxicity Renal insufficiency Tamm-Horsfall Protein creatinine Tamm Horsfall glycoprotein adult aged article clinical article controlled study creatinine blood level disease marker enzyme linked immunosorbent assay female human kidney failure liver transplantation male prediction priority journal protein secretion protein synthesis urinalysis urinary excretion Adolescent Adult Aged Biological Markers Creatinine Female Humans Immunoassay Kidney Kidney Failure Kidney Transplantation Male Middle Aged Mucoproteins Time Factors Romero, M.C. Zanaro, N. González, L. Trigo, P. Imventarza, O. Nesse, A. Tamm-Horsfall protein excretion to predict the onset of renal insufficiency |
topic_facet |
Biochemical markers Immunotherapy Liver transplantation Nephrotoxicity Renal insufficiency Tamm-Horsfall Protein creatinine Tamm Horsfall glycoprotein adult aged article clinical article controlled study creatinine blood level disease marker enzyme linked immunosorbent assay female human kidney failure liver transplantation male prediction priority journal protein secretion protein synthesis urinalysis urinary excretion Adolescent Adult Aged Biological Markers Creatinine Female Humans Immunoassay Kidney Kidney Failure Kidney Transplantation Male Middle Aged Mucoproteins Time Factors |
description |
Objective: Immunosuppressive therapy after liver transplantation may be a risk for kidney dysfunction. This work was designed to determine whether Tamm-Horsfall Protein (THP) could be considered as a marker for nephrotoxicity. Design and Methods: THP was determined by an ELISA method in serial 24-h urine from liver transplant patients. Fourteen patients suffered renal insufficiency (LTr1) and 20 showed no acute renal damage (LTr2) after liver transplantation. Results: No clear association could be seen between daily THP excretion and plasma creatinine levels by comparing serial samples collected at the same time. Nevertheless, significant differences were observed in pretransplant THP excretion between both groups of patients. The results (Median/Interquartile Range) were: Controls: 113.2/84.9 to 146.8 mg/24 h (n = 30); LTr1: 36.9/18.3 to 54.5 mg/24 h (p≪0.001 with respect to C and LTr2); LTr2: 90.8/61.5 to 139.7 mg/24 h. Conclusions: The higher pretransplant synthesis and/or secretion of THP seem to have a protective role on the kidney during and after liver transplantation. © 2002 The Canadian Society of Clinical Chemists. All rights reserved. |
format |
JOUR |
author |
Romero, M.C. Zanaro, N. González, L. Trigo, P. Imventarza, O. Nesse, A. |
author_facet |
Romero, M.C. Zanaro, N. González, L. Trigo, P. Imventarza, O. Nesse, A. |
author_sort |
Romero, M.C. |
title |
Tamm-Horsfall protein excretion to predict the onset of renal insufficiency |
title_short |
Tamm-Horsfall protein excretion to predict the onset of renal insufficiency |
title_full |
Tamm-Horsfall protein excretion to predict the onset of renal insufficiency |
title_fullStr |
Tamm-Horsfall protein excretion to predict the onset of renal insufficiency |
title_full_unstemmed |
Tamm-Horsfall protein excretion to predict the onset of renal insufficiency |
title_sort |
tamm-horsfall protein excretion to predict the onset of renal insufficiency |
url |
http://hdl.handle.net/20.500.12110/paper_00099120_v35_n1_p65_Romero |
work_keys_str_mv |
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