Structural and functional complexity of the humoral response against the Trypanosoma cruzi ribosomal P2β protein in patients with chronic Chagas' heart disease

High levels of antibodies against the C-terminus of the Trypanosoma cruzi TcP2β ribosomal protein, defined by the peptide EEEDDDMGFGLFD, named R13, have been measured in sera from patients with chronic Chagas' Heart Disease (cChHD). These antibodies also recognize an epitope on the second extra...

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Detalles Bibliográficos
Autores principales:	Mahler, E., Hoebeke, J., Levin, M.J.
Formato:	JOUR
Materias:	β1-adrenergic receptor Chronic Chagas' heart disease M2-cholinergic receptor Ribosomal P proteins Trypanosoma cruzi beta 1 adrenergic receptor epitope glutamylglutamylserylaspartylaspartylaspartylmethionylglycylphenylalanylgly cylleucylphenylalanylaspartic acid muscarinic M2 receptor parasite antigen peptide antibody peptide derivative protozoal protein r13 antibody ribosome protein trypanosoma cruzi ribosomal p2beta protein unclassified drug animal cell animal tissue antibody affinity antibody detection antibody specificity antigen recognition article Chagas disease chronic disease controlled study cross reaction host parasite interaction human humoral immunity immunoreactivity major clinical study molecular recognition nonhuman parasite virulence pathophysiology priority journal protein binding protein phosphorylation protozoal infection rat structure activity relation Animals Antibodies, Protozoan Cells, Cultured Chagas Disease Cross Reactions Enzyme-Linked Immunosorbent Assay Epitope Mapping Epitopes Humans Myocytes, Cardiac Rats Rats, Sprague-Dawley Receptors, Adrenergic, beta Receptors, Cholinergic Ribosomal Proteins
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00099104_v136_n3_p527_Mahler
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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