Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition

Background: Increased concentration of plasmatic homocysteine (tHcy) and decreased vitamin B 12 (B12) and folate (FOL) are associated with Alzheimer's (AD) and vascular (VaD) dementias, with type II diabetes mellitus (DM), and reported as risk factors of these diseases. Methods: The sample (n =...

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Autores principales: Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Famulari, A.L., Pagano, M.A., Serra, J.A.
Formato: JOUR
Materias:
Dementia of the Alzheimer's type
Dementia risk factors
Folate
Homocysteine
Non-insulin-dependent type II diabetes mellitus
Vascular dementia
Vitamin B 12
cyanocobalamin
folic acid
homocysteine
aged
Alzheimer disease
article
blood level
blood sampling
controlled study
female
human
male
multiinfarct dementia
non insulin dependent diabetes mellitus
priority journal
risk factor
sample size
statistical analysis
Aged
Alzheimer Disease
Analysis of Variance
Dementia, Vascular
Diabetes Mellitus, Type 2
Female
Folic Acid
Humans
Male
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00098981_v359_n1-2_p163_Dominguez
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_00098981_v359_n1-2_p163_Dominguez2023-10-03T14:08:45Z Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition Domínguez, R.O. Marschoff, E.R. Guareschi, E.M. Famulari, A.L. Pagano, M.A. Serra, J.A. Dementia of the Alzheimer's type Dementia risk factors Folate Homocysteine Non-insulin-dependent type II diabetes mellitus Vascular dementia Vitamin B 12 cyanocobalamin folic acid homocysteine aged Alzheimer disease article blood level blood sampling controlled study female human male multiinfarct dementia non insulin dependent diabetes mellitus priority journal risk factor sample size statistical analysis Aged Alzheimer Disease Analysis of Variance Dementia, Vascular Diabetes Mellitus, Type 2 Female Folic Acid Homocysteine Humans Male Vitamin B 12 Background: Increased concentration of plasmatic homocysteine (tHcy) and decreased vitamin B 12 (B12) and folate (FOL) are associated with Alzheimer's (AD) and vascular (VaD) dementias, with type II diabetes mellitus (DM), and reported as risk factors of these diseases. Methods: The sample (n = 122; males = 60; mean age = 73 ± 7 years) comprised AD and VaD patients without DM, with a concomitant DM (AD + DM, VaD + DM), DM alone and controls (CTR), resulting in 6 groups. tHcy, B12 and FOL were determined in duplicate. Results: The one-way ANOVA yielded significant differences between groups for all variables: tHcy p < 10-12; B12 p < 10-3; FOL p < 10-4. Significance for comparisons between groups was set at α = 0.05, using the Bonferroni's statistic. The comparisons: DM vs. CTR, AD + DM vs. AD, VaD + DM vs. VaD, and DM demented vs. DM non-demented resulted significant for all variables, except for B12 in 2 comparisons. Conclusions: In demented and control subjects, tHcy and FOL exhibit extreme differences, not so marked between DM and controls. Demented patients with concomitant diabetes are closer to controls than their non-diabetic counterparts. Diabetes affects tHcy and FOL values, which are changed with opposite sign to non-demented. These results suggests a paradoxical phenomenon when diabetes is superimposed to dementias. © 2005 Elsevier B.V. All rights reserved. Fil:Marschoff, E.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00098981_v359_n1-2_p163_Dominguez
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Dementia of the Alzheimer's type
Dementia risk factors
Folate
Homocysteine
Non-insulin-dependent type II diabetes mellitus
Vascular dementia
Vitamin B 12
cyanocobalamin
folic acid
homocysteine
aged
Alzheimer disease
article
blood level
blood sampling
controlled study
female
human
male
multiinfarct dementia
non insulin dependent diabetes mellitus
priority journal
risk factor
sample size
statistical analysis
Aged
Alzheimer Disease
Analysis of Variance
Dementia, Vascular
Diabetes Mellitus, Type 2
Female
Folic Acid
Homocysteine
Humans
Male
Vitamin B 12
spellingShingle Dementia of the Alzheimer's type
Dementia risk factors
Folate
Homocysteine
Non-insulin-dependent type II diabetes mellitus
Vascular dementia
Vitamin B 12
cyanocobalamin
folic acid
homocysteine
aged
Alzheimer disease
article
blood level
blood sampling
controlled study
female
human
male
multiinfarct dementia
non insulin dependent diabetes mellitus
priority journal
risk factor
sample size
statistical analysis
Aged
Alzheimer Disease
Analysis of Variance
Dementia, Vascular
Diabetes Mellitus, Type 2
Female
Folic Acid
Homocysteine
Humans
Male
Vitamin B 12
Domínguez, R.O.
Marschoff, E.R.
Guareschi, E.M.
Famulari, A.L.
Pagano, M.A.
Serra, J.A.
Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition
topic_facet Dementia of the Alzheimer's type
Dementia risk factors
Folate
Homocysteine
Non-insulin-dependent type II diabetes mellitus
Vascular dementia
Vitamin B 12
cyanocobalamin
folic acid
homocysteine
aged
Alzheimer disease
article
blood level
blood sampling
controlled study
female
human
male
multiinfarct dementia
non insulin dependent diabetes mellitus
priority journal
risk factor
sample size
statistical analysis
Aged
Alzheimer Disease
Analysis of Variance
Dementia, Vascular
Diabetes Mellitus, Type 2
Female
Folic Acid
Homocysteine
Humans
Male
Vitamin B 12
description Background: Increased concentration of plasmatic homocysteine (tHcy) and decreased vitamin B 12 (B12) and folate (FOL) are associated with Alzheimer's (AD) and vascular (VaD) dementias, with type II diabetes mellitus (DM), and reported as risk factors of these diseases. Methods: The sample (n = 122; males = 60; mean age = 73 ± 7 years) comprised AD and VaD patients without DM, with a concomitant DM (AD + DM, VaD + DM), DM alone and controls (CTR), resulting in 6 groups. tHcy, B12 and FOL were determined in duplicate. Results: The one-way ANOVA yielded significant differences between groups for all variables: tHcy p < 10-12; B12 p < 10-3; FOL p < 10-4. Significance for comparisons between groups was set at α = 0.05, using the Bonferroni's statistic. The comparisons: DM vs. CTR, AD + DM vs. AD, VaD + DM vs. VaD, and DM demented vs. DM non-demented resulted significant for all variables, except for B12 in 2 comparisons. Conclusions: In demented and control subjects, tHcy and FOL exhibit extreme differences, not so marked between DM and controls. Demented patients with concomitant diabetes are closer to controls than their non-diabetic counterparts. Diabetes affects tHcy and FOL values, which are changed with opposite sign to non-demented. These results suggests a paradoxical phenomenon when diabetes is superimposed to dementias. © 2005 Elsevier B.V. All rights reserved.
format JOUR
author Domínguez, R.O.
Marschoff, E.R.
Guareschi, E.M.
Famulari, A.L.
Pagano, M.A.
Serra, J.A.
author_facet Domínguez, R.O.
Marschoff, E.R.
Guareschi, E.M.
Famulari, A.L.
Pagano, M.A.
Serra, J.A.
author_sort Domínguez, R.O.
title Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition
title_short Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition
title_full Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition
title_fullStr Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition
title_full_unstemmed Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition
title_sort homocysteine, vitamin b 12 and folate in alzheimer's and vascular dementias: the paradoxical effect of the superimposed type ii diabetes mellitus condition
url http://hdl.handle.net/20.500.12110/paper_00098981_v359_n1-2_p163_Dominguez
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