Effect of chagasic sera on the rat isolated atrial preparation: Immunological, morphological and functional aspects
AUTHORS' SYNOPSIS: An antibody reacting with the plasma membrane of working myocardial cells, skeletal muscle fibres, and endothelial cells (EVI antibody) has been described in the sera of patients with Chagas' disease. In the present study of rat isolated atrial preparations beating in di...
Guardado en:
Autores principales: | , , , , , , , |
---|---|
Formato: | JOUR |
Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00086363_v10_n6_p613_SterinBorda |
Aporte de: |
id |
todo:paper_00086363_v10_n6_p613_SterinBorda |
---|---|
record_format |
dspace |
spelling |
todo:paper_00086363_v10_n6_p613_SterinBorda2023-10-03T14:07:42Z Effect of chagasic sera on the rat isolated atrial preparation: Immunological, morphological and functional aspects Sterin-Borda, L. Cossio, P.M. Gimeno, M.F. Gimeno, A.L. Diez, C. Laguens, R.P. Meckert, P.C. Arana, R.M. AUTHORS' SYNOPSIS: An antibody reacting with the plasma membrane of working myocardial cells, skeletal muscle fibres, and endothelial cells (EVI antibody) has been described in the sera of patients with Chagas' disease. In the present study of rat isolated atrial preparations beating in different media, direct immunofluorescence and ultrastructural immunohistochemical procedures indicate that the antibody can interact with the living tissue, becoming fixed to the plasma membranes. Transmission electronmicroscopy studies also showed the presence of sarcolemmal alterations. These observations suggest a possible pathogenic effect of the EVI antibody. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00086363_v10_n6_p613_SterinBorda |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
description |
AUTHORS' SYNOPSIS: An antibody reacting with the plasma membrane of working myocardial cells, skeletal muscle fibres, and endothelial cells (EVI antibody) has been described in the sera of patients with Chagas' disease. In the present study of rat isolated atrial preparations beating in different media, direct immunofluorescence and ultrastructural immunohistochemical procedures indicate that the antibody can interact with the living tissue, becoming fixed to the plasma membranes. Transmission electronmicroscopy studies also showed the presence of sarcolemmal alterations. These observations suggest a possible pathogenic effect of the EVI antibody. |
format |
JOUR |
author |
Sterin-Borda, L. Cossio, P.M. Gimeno, M.F. Gimeno, A.L. Diez, C. Laguens, R.P. Meckert, P.C. Arana, R.M. |
spellingShingle |
Sterin-Borda, L. Cossio, P.M. Gimeno, M.F. Gimeno, A.L. Diez, C. Laguens, R.P. Meckert, P.C. Arana, R.M. Effect of chagasic sera on the rat isolated atrial preparation: Immunological, morphological and functional aspects |
author_facet |
Sterin-Borda, L. Cossio, P.M. Gimeno, M.F. Gimeno, A.L. Diez, C. Laguens, R.P. Meckert, P.C. Arana, R.M. |
author_sort |
Sterin-Borda, L. |
title |
Effect of chagasic sera on the rat isolated atrial preparation: Immunological, morphological and functional aspects |
title_short |
Effect of chagasic sera on the rat isolated atrial preparation: Immunological, morphological and functional aspects |
title_full |
Effect of chagasic sera on the rat isolated atrial preparation: Immunological, morphological and functional aspects |
title_fullStr |
Effect of chagasic sera on the rat isolated atrial preparation: Immunological, morphological and functional aspects |
title_full_unstemmed |
Effect of chagasic sera on the rat isolated atrial preparation: Immunological, morphological and functional aspects |
title_sort |
effect of chagasic sera on the rat isolated atrial preparation: immunological, morphological and functional aspects |
url |
http://hdl.handle.net/20.500.12110/paper_00086363_v10_n6_p613_SterinBorda |
work_keys_str_mv |
AT sterinbordal effectofchagasicseraontheratisolatedatrialpreparationimmunologicalmorphologicalandfunctionalaspects AT cossiopm effectofchagasicseraontheratisolatedatrialpreparationimmunologicalmorphologicalandfunctionalaspects AT gimenomf effectofchagasicseraontheratisolatedatrialpreparationimmunologicalmorphologicalandfunctionalaspects AT gimenoal effectofchagasicseraontheratisolatedatrialpreparationimmunologicalmorphologicalandfunctionalaspects AT diezc effectofchagasicseraontheratisolatedatrialpreparationimmunologicalmorphologicalandfunctionalaspects AT laguensrp effectofchagasicseraontheratisolatedatrialpreparationimmunologicalmorphologicalandfunctionalaspects AT meckertpc effectofchagasicseraontheratisolatedatrialpreparationimmunologicalmorphologicalandfunctionalaspects AT aranarm effectofchagasicseraontheratisolatedatrialpreparationimmunologicalmorphologicalandfunctionalaspects |
_version_ |
1782028901138038784 |