Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release

A novel cationized starch-based interpolyelectrolyte complex (IPEC) was formed using kappa-carrageenan as the counter polyion. Characterization of the product by turbidity measurements and elemental analyses indicated a 1:1 interaction of the repeating units. FT-IR spectra for the IPEC showed some d...

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Autores principales:	Prado, H.J., Matulewicz, M.C., Bonelli, P.R., Cukierman, A.L.
Formato:	JOUR
Materias:	Cationized starch Controlled release Ibuprofen Interpolyelectrolyte complex Kappa-carrageenan Matrix system Dissolution Starch Turbidity Controlled drug delivery buffer ibuprofen polyelectrolyte starch article controlled drug release diffusion dissolution drug delivery system drug synthesis infrared spectroscopy measurement performance pH priority journal tablet tablet matrix turbidity Amylose Carbohydrate Sequence Carrageenan Diffusion Drug Carriers Electrolytes Pharmaceutical Preparations Quaternary Ammonium Compounds Spectroscopy, Fourier Transform Infrared Tablets
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00086215_v344_n11_p1325_Prado
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00086215_v344_n11_p1325_Prado
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spelling	todo:paper_00086215_v344_n11_p1325_Prado2023-10-03T14:07:19Z Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release Prado, H.J. Matulewicz, M.C. Bonelli, P.R. Cukierman, A.L. Cationized starch Controlled release Ibuprofen Interpolyelectrolyte complex Kappa-carrageenan Matrix system Cationized starch Controlled release Ibuprofen Interpolyelectrolyte complex Kappa-carrageenan Matrix system Dissolution Starch Turbidity Controlled drug delivery buffer ibuprofen polyelectrolyte starch article controlled drug release diffusion dissolution drug delivery system drug synthesis infrared spectroscopy measurement performance pH priority journal tablet tablet matrix turbidity Amylose Carbohydrate Sequence Carrageenan Diffusion Drug Carriers Electrolytes Ibuprofen Pharmaceutical Preparations Quaternary Ammonium Compounds Spectroscopy, Fourier Transform Infrared Starch Tablets A novel cationized starch-based interpolyelectrolyte complex (IPEC) was formed using kappa-carrageenan as the counter polyion. Characterization of the product by turbidity measurements and elemental analyses indicated a 1:1 interaction of the repeating units. FT-IR spectra for the IPEC showed some differences in comparison with either IPEC constituents or physical mixture. The swelling of tablets obtained by direct compression was independent of pH, and a maximum value of 742% was attained after 24 h. The performance of the IPEC as matrix for controlled release of ibuprofen indicates that drug delivery takes place in a zero-order manner. Experimental dissolution data in the buffer stage were properly represented by a model accounting for contributions of Fickian diffusion and relaxation phenomena; this model suggests that the former predominates over the latter, for the modeled range. © 2009 Elsevier Ltd. All rights reserved. Fil:Prado, H.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Matulewicz, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bonelli, P.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cukierman, A.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00086215_v344_n11_p1325_Prado
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cationized starch Controlled release Ibuprofen Interpolyelectrolyte complex Kappa-carrageenan Matrix system Cationized starch Controlled release Ibuprofen Interpolyelectrolyte complex Kappa-carrageenan Matrix system Dissolution Starch Turbidity Controlled drug delivery buffer ibuprofen polyelectrolyte starch article controlled drug release diffusion dissolution drug delivery system drug synthesis infrared spectroscopy measurement performance pH priority journal tablet tablet matrix turbidity Amylose Carbohydrate Sequence Carrageenan Diffusion Drug Carriers Electrolytes Ibuprofen Pharmaceutical Preparations Quaternary Ammonium Compounds Spectroscopy, Fourier Transform Infrared Starch Tablets
spellingShingle	Cationized starch Controlled release Ibuprofen Interpolyelectrolyte complex Kappa-carrageenan Matrix system Cationized starch Controlled release Ibuprofen Interpolyelectrolyte complex Kappa-carrageenan Matrix system Dissolution Starch Turbidity Controlled drug delivery buffer ibuprofen polyelectrolyte starch article controlled drug release diffusion dissolution drug delivery system drug synthesis infrared spectroscopy measurement performance pH priority journal tablet tablet matrix turbidity Amylose Carbohydrate Sequence Carrageenan Diffusion Drug Carriers Electrolytes Ibuprofen Pharmaceutical Preparations Quaternary Ammonium Compounds Spectroscopy, Fourier Transform Infrared Starch Tablets Prado, H.J. Matulewicz, M.C. Bonelli, P.R. Cukierman, A.L. Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
topic_facet	Cationized starch Controlled release Ibuprofen Interpolyelectrolyte complex Kappa-carrageenan Matrix system Cationized starch Controlled release Ibuprofen Interpolyelectrolyte complex Kappa-carrageenan Matrix system Dissolution Starch Turbidity Controlled drug delivery buffer ibuprofen polyelectrolyte starch article controlled drug release diffusion dissolution drug delivery system drug synthesis infrared spectroscopy measurement performance pH priority journal tablet tablet matrix turbidity Amylose Carbohydrate Sequence Carrageenan Diffusion Drug Carriers Electrolytes Ibuprofen Pharmaceutical Preparations Quaternary Ammonium Compounds Spectroscopy, Fourier Transform Infrared Starch Tablets
description	A novel cationized starch-based interpolyelectrolyte complex (IPEC) was formed using kappa-carrageenan as the counter polyion. Characterization of the product by turbidity measurements and elemental analyses indicated a 1:1 interaction of the repeating units. FT-IR spectra for the IPEC showed some differences in comparison with either IPEC constituents or physical mixture. The swelling of tablets obtained by direct compression was independent of pH, and a maximum value of 742% was attained after 24 h. The performance of the IPEC as matrix for controlled release of ibuprofen indicates that drug delivery takes place in a zero-order manner. Experimental dissolution data in the buffer stage were properly represented by a model accounting for contributions of Fickian diffusion and relaxation phenomena; this model suggests that the former predominates over the latter, for the modeled range. © 2009 Elsevier Ltd. All rights reserved.
format	JOUR
author	Prado, H.J. Matulewicz, M.C. Bonelli, P.R. Cukierman, A.L.
author_facet	Prado, H.J. Matulewicz, M.C. Bonelli, P.R. Cukierman, A.L.
author_sort	Prado, H.J.
title	Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
title_short	Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
title_full	Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
title_fullStr	Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
title_full_unstemmed	Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
title_sort	preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
url	http://hdl.handle.net/20.500.12110/paper_00086215_v344_n11_p1325_Prado
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Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release

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