The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans
The sulfated agaran isolated by water extraction from the red seaweed, Acanthophora spicifera (Rhodomelaceae, Ceramiales), is made up of A-units highly substituted with sulfate groups on C-2 (28-30%), sulfates on C-2 and 4,6-O-(1′-carboxyethylidene) groups (9-15%), and only the C-2 sulfate groups (5...
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todo:paper_00086215_v339_n2_p335_Duarte2023-10-03T14:07:05Z The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans Duarte, M.E.R. Cauduro, J.P. Noseda, D.G. Noseda, M.D. Gonçalves, A.G. Pujol, C.A. Damonte, E.B. Cerezo, A.S. Acanthophora spicifera Antiviral activity Chemical structure Herpes simplex virus Methylation analysis NMR spectroscopy Rhodomelaceae Seaweed Sulfated agarans Glucose Sulfur compounds Viruses Antiviral activity Seaweed 2 o methyl alpha galactose 3,6 anhydro alpha galactose 3,6 anhydro alpha galactose 2 sulfate agaran sulfate alpha galactose 2,3,6 trisulfate alpha galactose 2,6 disulfate alpha galactose 2,6 disulfate 3 xylose alpha galactose 6 sulfate beta xylose galactose sulfate unclassified drug water xylose acanthophora spicifera animal cell antiviral activity article controlled study correlation analysis drug structure extraction nonhuman priority journal quantitative analysis seaweed structure activity relation structure analysis sulfation Acanthophora Acanthophora spicifera algae Ceramiales Rhodomelaceae Simplexvirus The sulfated agaran isolated by water extraction from the red seaweed, Acanthophora spicifera (Rhodomelaceae, Ceramiales), is made up of A-units highly substituted with sulfate groups on C-2 (28-30%), sulfates on C-2 and 4,6-O-(1′-carboxyethylidene) groups (9-15%), and only the C-2 sulfate groups (5-8%) with small amounts of C-6 sulfate, 6-O-methyl, and nonsubstituted residues. B-units are formed mainly by 3,6-anhydro-α-L-galactose (15-16%) and its precursor, α-L-galactose 6-sulfate (10-17%), together with lesser amounts of 3,6-anhydro-α-L-galactose 2-sulfate, α-L-galactose 2,6-disulfate, α-L-galactose 2,3,6-tri-sulfate, α-L-galactose 2,6-disulfate 3-xylose, 2-O-methyl-α-L-galactose, and unsubstituted α-L-galactose. Small, but significant quantities of β-D-xylose were found in all the fractions, together with small amounts to traces of D-glucose. Some of the fractions have high antiviral activity. Attempts to correlate structure and antiviral activity in agarans are presented. © 2003 Elsevier Ltd. All rights reserved. Fil:Noseda, M.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pujol, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cerezo, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00086215_v339_n2_p335_Duarte |
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Universidad de Buenos Aires |
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I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Acanthophora spicifera Antiviral activity Chemical structure Herpes simplex virus Methylation analysis NMR spectroscopy Rhodomelaceae Seaweed Sulfated agarans Glucose Sulfur compounds Viruses Antiviral activity Seaweed 2 o methyl alpha galactose 3,6 anhydro alpha galactose 3,6 anhydro alpha galactose 2 sulfate agaran sulfate alpha galactose 2,3,6 trisulfate alpha galactose 2,6 disulfate alpha galactose 2,6 disulfate 3 xylose alpha galactose 6 sulfate beta xylose galactose sulfate unclassified drug water xylose acanthophora spicifera animal cell antiviral activity article controlled study correlation analysis drug structure extraction nonhuman priority journal quantitative analysis seaweed structure activity relation structure analysis sulfation Acanthophora Acanthophora spicifera algae Ceramiales Rhodomelaceae Simplexvirus |
| spellingShingle |
Acanthophora spicifera Antiviral activity Chemical structure Herpes simplex virus Methylation analysis NMR spectroscopy Rhodomelaceae Seaweed Sulfated agarans Glucose Sulfur compounds Viruses Antiviral activity Seaweed 2 o methyl alpha galactose 3,6 anhydro alpha galactose 3,6 anhydro alpha galactose 2 sulfate agaran sulfate alpha galactose 2,3,6 trisulfate alpha galactose 2,6 disulfate alpha galactose 2,6 disulfate 3 xylose alpha galactose 6 sulfate beta xylose galactose sulfate unclassified drug water xylose acanthophora spicifera animal cell antiviral activity article controlled study correlation analysis drug structure extraction nonhuman priority journal quantitative analysis seaweed structure activity relation structure analysis sulfation Acanthophora Acanthophora spicifera algae Ceramiales Rhodomelaceae Simplexvirus Duarte, M.E.R. Cauduro, J.P. Noseda, D.G. Noseda, M.D. Gonçalves, A.G. Pujol, C.A. Damonte, E.B. Cerezo, A.S. The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans |
| topic_facet |
Acanthophora spicifera Antiviral activity Chemical structure Herpes simplex virus Methylation analysis NMR spectroscopy Rhodomelaceae Seaweed Sulfated agarans Glucose Sulfur compounds Viruses Antiviral activity Seaweed 2 o methyl alpha galactose 3,6 anhydro alpha galactose 3,6 anhydro alpha galactose 2 sulfate agaran sulfate alpha galactose 2,3,6 trisulfate alpha galactose 2,6 disulfate alpha galactose 2,6 disulfate 3 xylose alpha galactose 6 sulfate beta xylose galactose sulfate unclassified drug water xylose acanthophora spicifera animal cell antiviral activity article controlled study correlation analysis drug structure extraction nonhuman priority journal quantitative analysis seaweed structure activity relation structure analysis sulfation Acanthophora Acanthophora spicifera algae Ceramiales Rhodomelaceae Simplexvirus |
| description |
The sulfated agaran isolated by water extraction from the red seaweed, Acanthophora spicifera (Rhodomelaceae, Ceramiales), is made up of A-units highly substituted with sulfate groups on C-2 (28-30%), sulfates on C-2 and 4,6-O-(1′-carboxyethylidene) groups (9-15%), and only the C-2 sulfate groups (5-8%) with small amounts of C-6 sulfate, 6-O-methyl, and nonsubstituted residues. B-units are formed mainly by 3,6-anhydro-α-L-galactose (15-16%) and its precursor, α-L-galactose 6-sulfate (10-17%), together with lesser amounts of 3,6-anhydro-α-L-galactose 2-sulfate, α-L-galactose 2,6-disulfate, α-L-galactose 2,3,6-tri-sulfate, α-L-galactose 2,6-disulfate 3-xylose, 2-O-methyl-α-L-galactose, and unsubstituted α-L-galactose. Small, but significant quantities of β-D-xylose were found in all the fractions, together with small amounts to traces of D-glucose. Some of the fractions have high antiviral activity. Attempts to correlate structure and antiviral activity in agarans are presented. © 2003 Elsevier Ltd. All rights reserved. |
| format |
JOUR |
| author |
Duarte, M.E.R. Cauduro, J.P. Noseda, D.G. Noseda, M.D. Gonçalves, A.G. Pujol, C.A. Damonte, E.B. Cerezo, A.S. |
| author_facet |
Duarte, M.E.R. Cauduro, J.P. Noseda, D.G. Noseda, M.D. Gonçalves, A.G. Pujol, C.A. Damonte, E.B. Cerezo, A.S. |
| author_sort |
Duarte, M.E.R. |
| title |
The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans |
| title_short |
The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans |
| title_full |
The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans |
| title_fullStr |
The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans |
| title_full_unstemmed |
The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans |
| title_sort |
structure of the agaran sulfate from acanthophora spicifera (rhodomelaceae, ceramiales) and its antiviral activity. relation between structure and antiviral activity in agarans |
| url |
http://hdl.handle.net/20.500.12110/paper_00086215_v339_n2_p335_Duarte |
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