Role of corticosteroids in distal acidification of amiloride-treated rats

The role of amiloride-dependent sodium channels in the action of adrenal cortical steroids on urine-blood PCO2 (U-B PCO2) differences was studied in bicarbonate-infused and amiloride-treated adrenalectomized rats. U-B PCO2 was significantly reduced by amiloride in bicarbonate-infused control rats. A...

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Autores principales:	Ansaldo, M., Damasco, M.C., De Lavallaz, M.S., Lantos, C.P., Malnic, G.
Formato:	JOUR
Materias:	18-hydroxycorticosterone adrenalectomy aldosterone amiloride corticos terone corticosteroids distal H ion secretion 18 hydroxycorticosterone corticosterone animal experiment article controlled study intramuscular drug administration intravenous drug administration kidney distal tubule male nonhuman priority journal rat urine acidification
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00084212_v70_n5_p695_Ansaldo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00084212_v70_n5_p695_Ansaldo
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spelling	todo:paper_00084212_v70_n5_p695_Ansaldo2023-10-03T14:06:05Z Role of corticosteroids in distal acidification of amiloride-treated rats Ansaldo, M. Damasco, M.C. De Lavallaz, M.S. Lantos, C.P. Malnic, G. 18-hydroxycorticosterone adrenalectomy aldosterone amiloride corticos terone corticosteroids distal H ion secretion 18 hydroxycorticosterone aldosterone amiloride corticosterone adrenalectomy animal experiment article controlled study intramuscular drug administration intravenous drug administration kidney distal tubule male nonhuman priority journal rat urine acidification The role of amiloride-dependent sodium channels in the action of adrenal cortical steroids on urine-blood PCO2 (U-B PCO2) differences was studied in bicarbonate-infused and amiloride-treated adrenalectomized rats. U-B PCO2 was significantly reduced by amiloride in bicarbonate-infused control rats. Adrenalectomy further reduced U-B PCO2 in amiloride-treated, bicarbonate-infused rats (from 27.9 ± 1.82 mmHg in sham-operated rats to 21.3 ± 1.58 mmHg in adrenalectomized (ADX) rats) (1 mmHg = 133.322 Pa). Acute administration of corticosterone and 18-hydroxycorticosterone (18-OH-B), but not of aldosterone, caused recovery of U-B PCO2 to the level of sham-operated animals treated with amiloride. Aldosterone did not affect U-B PCO2 in the presence of amiloride (21.9 mmHg ADX group vs. 20.98 mmHg aldosterone group). Results are compatible with aldosterone affecting distal H ion secretion mostly by a sodium and potential difference dependent mechanism, while corticosterone and 18-OH-B should act by other mechanisms (e.g., increased luminal buffer level). Fil:Ansaldo, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00084212_v70_n5_p695_Ansaldo
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	18-hydroxycorticosterone adrenalectomy aldosterone amiloride corticos terone corticosteroids distal H ion secretion 18 hydroxycorticosterone aldosterone amiloride corticosterone adrenalectomy animal experiment article controlled study intramuscular drug administration intravenous drug administration kidney distal tubule male nonhuman priority journal rat urine acidification
spellingShingle	18-hydroxycorticosterone adrenalectomy aldosterone amiloride corticos terone corticosteroids distal H ion secretion 18 hydroxycorticosterone aldosterone amiloride corticosterone adrenalectomy animal experiment article controlled study intramuscular drug administration intravenous drug administration kidney distal tubule male nonhuman priority journal rat urine acidification Ansaldo, M. Damasco, M.C. De Lavallaz, M.S. Lantos, C.P. Malnic, G. Role of corticosteroids in distal acidification of amiloride-treated rats
topic_facet	18-hydroxycorticosterone adrenalectomy aldosterone amiloride corticos terone corticosteroids distal H ion secretion 18 hydroxycorticosterone aldosterone amiloride corticosterone adrenalectomy animal experiment article controlled study intramuscular drug administration intravenous drug administration kidney distal tubule male nonhuman priority journal rat urine acidification
description	The role of amiloride-dependent sodium channels in the action of adrenal cortical steroids on urine-blood PCO2 (U-B PCO2) differences was studied in bicarbonate-infused and amiloride-treated adrenalectomized rats. U-B PCO2 was significantly reduced by amiloride in bicarbonate-infused control rats. Adrenalectomy further reduced U-B PCO2 in amiloride-treated, bicarbonate-infused rats (from 27.9 ± 1.82 mmHg in sham-operated rats to 21.3 ± 1.58 mmHg in adrenalectomized (ADX) rats) (1 mmHg = 133.322 Pa). Acute administration of corticosterone and 18-hydroxycorticosterone (18-OH-B), but not of aldosterone, caused recovery of U-B PCO2 to the level of sham-operated animals treated with amiloride. Aldosterone did not affect U-B PCO2 in the presence of amiloride (21.9 mmHg ADX group vs. 20.98 mmHg aldosterone group). Results are compatible with aldosterone affecting distal H ion secretion mostly by a sodium and potential difference dependent mechanism, while corticosterone and 18-OH-B should act by other mechanisms (e.g., increased luminal buffer level).
format	JOUR
author	Ansaldo, M. Damasco, M.C. De Lavallaz, M.S. Lantos, C.P. Malnic, G.
author_facet	Ansaldo, M. Damasco, M.C. De Lavallaz, M.S. Lantos, C.P. Malnic, G.
author_sort	Ansaldo, M.
title	Role of corticosteroids in distal acidification of amiloride-treated rats
title_short	Role of corticosteroids in distal acidification of amiloride-treated rats
title_full	Role of corticosteroids in distal acidification of amiloride-treated rats
title_fullStr	Role of corticosteroids in distal acidification of amiloride-treated rats
title_full_unstemmed	Role of corticosteroids in distal acidification of amiloride-treated rats
title_sort	role of corticosteroids in distal acidification of amiloride-treated rats
url	http://hdl.handle.net/20.500.12110/paper_00084212_v70_n5_p695_Ansaldo
work_keys_str_mv	AT ansaldom roleofcorticosteroidsindistalacidificationofamiloridetreatedrats AT damascomc roleofcorticosteroidsindistalacidificationofamiloridetreatedrats AT delavallazms roleofcorticosteroidsindistalacidificationofamiloridetreatedrats AT lantoscp roleofcorticosteroidsindistalacidificationofamiloridetreatedrats AT malnicg roleofcorticosteroidsindistalacidificationofamiloridetreatedrats
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Role of corticosteroids in distal acidification of amiloride-treated rats

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