Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus
The toxic effect of sublethal concentrations (1, 17.5 and 35 mg L -1) of pure glyphosate was evaluated on acetylcholinesterase (AChE) activity in the fish species, Cnesterodon decemmaculatus. Acute bioassays (96 h) under laboratory conditions were conducted and homogenates for each specimen correspo...
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todo:paper_00074861_v88_n1_p6_MenendezHelman2023-10-03T14:05:45Z Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus Menéndez-Helman, R.J. Ferreyroa, G.V. Dos Santos Afonso, M. Salibián, A. AChE Cnesterodon decemmaculatus Glyphosate Toxicity bioassay Acetylcholinesterase AChE Analytical determination Cnesterodon decemmaculatus Fish species Fish survival Glyphosate Glyphosates Herbicide concentration Inhibitory effect Laboratory conditions Neurotoxicity Toxic effect Bioassay Toxicity Herbicides acetylcholinesterase cholinesterase inhibitor drug derivative glycine glyphosate animal article Cyprinodontiformes dose response metabolism physiology water pollutant Acetylcholinesterase Animals Cholinesterase Inhibitors Cyprinodontiformes Dose-Response Relationship, Drug Glycine Water Pollutants, Chemical Cnesterodon decemmaculatus The toxic effect of sublethal concentrations (1, 17.5 and 35 mg L -1) of pure glyphosate was evaluated on acetylcholinesterase (AChE) activity in the fish species, Cnesterodon decemmaculatus. Acute bioassays (96 h) under laboratory conditions were conducted and homogenates for each specimen corresponding to the anterior, middle and posterior body sections were performed. Fish survival was 100%, even at the highest concentration tested (35 mg L -1), in accordance with the low lethal toxicity reported for glyphosate. However, a significant inhibitory effect on AChE activity was recorded even for the lowest herbicide concentration tested (1 mg L -1), in the homogenates corresponding to the anterior body section. The inhibition ranged from 23 to 36%. The analytical determination of glyphosate in assay media by ion chromatography, was used to verify its stability. These results indicate that AChE-a neurotoxicity biomarker-in C. decemmaculatus may be affected by exposure to environmentally relevant concentrations of glyphosate. © 2011 Springer Science+Business Media, LLC. Fil:Menéndez-Helman, R.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ferreyroa, G.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00074861_v88_n1_p6_MenendezHelman |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
AChE Cnesterodon decemmaculatus Glyphosate Toxicity bioassay Acetylcholinesterase AChE Analytical determination Cnesterodon decemmaculatus Fish species Fish survival Glyphosate Glyphosates Herbicide concentration Inhibitory effect Laboratory conditions Neurotoxicity Toxic effect Bioassay Toxicity Herbicides acetylcholinesterase cholinesterase inhibitor drug derivative glycine glyphosate animal article Cyprinodontiformes dose response metabolism physiology water pollutant Acetylcholinesterase Animals Cholinesterase Inhibitors Cyprinodontiformes Dose-Response Relationship, Drug Glycine Water Pollutants, Chemical Cnesterodon decemmaculatus |
| spellingShingle |
AChE Cnesterodon decemmaculatus Glyphosate Toxicity bioassay Acetylcholinesterase AChE Analytical determination Cnesterodon decemmaculatus Fish species Fish survival Glyphosate Glyphosates Herbicide concentration Inhibitory effect Laboratory conditions Neurotoxicity Toxic effect Bioassay Toxicity Herbicides acetylcholinesterase cholinesterase inhibitor drug derivative glycine glyphosate animal article Cyprinodontiformes dose response metabolism physiology water pollutant Acetylcholinesterase Animals Cholinesterase Inhibitors Cyprinodontiformes Dose-Response Relationship, Drug Glycine Water Pollutants, Chemical Cnesterodon decemmaculatus Menéndez-Helman, R.J. Ferreyroa, G.V. Dos Santos Afonso, M. Salibián, A. Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus |
| topic_facet |
AChE Cnesterodon decemmaculatus Glyphosate Toxicity bioassay Acetylcholinesterase AChE Analytical determination Cnesterodon decemmaculatus Fish species Fish survival Glyphosate Glyphosates Herbicide concentration Inhibitory effect Laboratory conditions Neurotoxicity Toxic effect Bioassay Toxicity Herbicides acetylcholinesterase cholinesterase inhibitor drug derivative glycine glyphosate animal article Cyprinodontiformes dose response metabolism physiology water pollutant Acetylcholinesterase Animals Cholinesterase Inhibitors Cyprinodontiformes Dose-Response Relationship, Drug Glycine Water Pollutants, Chemical Cnesterodon decemmaculatus |
| description |
The toxic effect of sublethal concentrations (1, 17.5 and 35 mg L -1) of pure glyphosate was evaluated on acetylcholinesterase (AChE) activity in the fish species, Cnesterodon decemmaculatus. Acute bioassays (96 h) under laboratory conditions were conducted and homogenates for each specimen corresponding to the anterior, middle and posterior body sections were performed. Fish survival was 100%, even at the highest concentration tested (35 mg L -1), in accordance with the low lethal toxicity reported for glyphosate. However, a significant inhibitory effect on AChE activity was recorded even for the lowest herbicide concentration tested (1 mg L -1), in the homogenates corresponding to the anterior body section. The inhibition ranged from 23 to 36%. The analytical determination of glyphosate in assay media by ion chromatography, was used to verify its stability. These results indicate that AChE-a neurotoxicity biomarker-in C. decemmaculatus may be affected by exposure to environmentally relevant concentrations of glyphosate. © 2011 Springer Science+Business Media, LLC. |
| format |
JOUR |
| author |
Menéndez-Helman, R.J. Ferreyroa, G.V. Dos Santos Afonso, M. Salibián, A. |
| author_facet |
Menéndez-Helman, R.J. Ferreyroa, G.V. Dos Santos Afonso, M. Salibián, A. |
| author_sort |
Menéndez-Helman, R.J. |
| title |
Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus |
| title_short |
Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus |
| title_full |
Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus |
| title_fullStr |
Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus |
| title_full_unstemmed |
Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus |
| title_sort |
glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus |
| url |
http://hdl.handle.net/20.500.12110/paper_00074861_v88_n1_p6_MenendezHelman |
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