Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland
The effect of melatonin on in vivo γ-aminobutyric acid (GABA) accumulation in several brain regions was determined by measuring the increase of GABA levels following inhibition of GABA transaminase. A single melatonin injection (25-300 μg/kg) augmented significantly, by 17-20%, GABA accumulation in...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00068993_v398_n2_p403_Rosenstein |
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todo:paper_00068993_v398_n2_p403_Rosenstein2023-10-03T14:05:22Z Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland Rosenstein, R.E. Cardinali, D.P. Cerebellum Cerebral cortex Hypothalamus Melatonin Pineal gland γ-Aminobutyric acid (GABA) 4 amino 5 hexynoic acid 4 aminobutyrate aminotransferase 4 aminobutyric acid melatonin animal experiment brain cortex central nervous system cerebellum drug interaction drug receptor binding intraperitoneal drug administration nonhuman pineal body priority journal rat 4-Aminobutyrate Transaminase Aminocaproic Acids Animal Brain Cerebellum Cerebral Cortex gamma-Aminobutyric Acid Hypothalamus Male Melatonin Pineal Gland Rats Rats, Inbred Strains Support, Non-U.S. Gov't The effect of melatonin on in vivo γ-aminobutyric acid (GABA) accumulation in several brain regions was determined by measuring the increase of GABA levels following inhibition of GABA transaminase. A single melatonin injection (25-300 μg/kg) augmented significantly, by 17-20%, GABA accumulation in the hypothalamus and caused a dose-dependent increase of this parameter in the pineal gland. Significant rises of GABA accumulation were found in the cerebellum and cerebral cortex after administering 100-300 and 300 μg/kg of melatonin, respectively. © 1986. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00068993_v398_n2_p403_Rosenstein |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cerebellum Cerebral cortex Hypothalamus Melatonin Pineal gland γ-Aminobutyric acid (GABA) 4 amino 5 hexynoic acid 4 aminobutyrate aminotransferase 4 aminobutyric acid melatonin animal experiment brain cortex central nervous system cerebellum drug interaction drug receptor binding intraperitoneal drug administration nonhuman pineal body priority journal rat 4-Aminobutyrate Transaminase Aminocaproic Acids Animal Brain Cerebellum Cerebral Cortex gamma-Aminobutyric Acid Hypothalamus Male Melatonin Pineal Gland Rats Rats, Inbred Strains Support, Non-U.S. Gov't |
| spellingShingle |
Cerebellum Cerebral cortex Hypothalamus Melatonin Pineal gland γ-Aminobutyric acid (GABA) 4 amino 5 hexynoic acid 4 aminobutyrate aminotransferase 4 aminobutyric acid melatonin animal experiment brain cortex central nervous system cerebellum drug interaction drug receptor binding intraperitoneal drug administration nonhuman pineal body priority journal rat 4-Aminobutyrate Transaminase Aminocaproic Acids Animal Brain Cerebellum Cerebral Cortex gamma-Aminobutyric Acid Hypothalamus Male Melatonin Pineal Gland Rats Rats, Inbred Strains Support, Non-U.S. Gov't Rosenstein, R.E. Cardinali, D.P. Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland |
| topic_facet |
Cerebellum Cerebral cortex Hypothalamus Melatonin Pineal gland γ-Aminobutyric acid (GABA) 4 amino 5 hexynoic acid 4 aminobutyrate aminotransferase 4 aminobutyric acid melatonin animal experiment brain cortex central nervous system cerebellum drug interaction drug receptor binding intraperitoneal drug administration nonhuman pineal body priority journal rat 4-Aminobutyrate Transaminase Aminocaproic Acids Animal Brain Cerebellum Cerebral Cortex gamma-Aminobutyric Acid Hypothalamus Male Melatonin Pineal Gland Rats Rats, Inbred Strains Support, Non-U.S. Gov't |
| description |
The effect of melatonin on in vivo γ-aminobutyric acid (GABA) accumulation in several brain regions was determined by measuring the increase of GABA levels following inhibition of GABA transaminase. A single melatonin injection (25-300 μg/kg) augmented significantly, by 17-20%, GABA accumulation in the hypothalamus and caused a dose-dependent increase of this parameter in the pineal gland. Significant rises of GABA accumulation were found in the cerebellum and cerebral cortex after administering 100-300 and 300 μg/kg of melatonin, respectively. © 1986. |
| format |
JOUR |
| author |
Rosenstein, R.E. Cardinali, D.P. |
| author_facet |
Rosenstein, R.E. Cardinali, D.P. |
| author_sort |
Rosenstein, R.E. |
| title |
Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland |
| title_short |
Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland |
| title_full |
Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland |
| title_fullStr |
Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland |
| title_full_unstemmed |
Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland |
| title_sort |
melatonin increases in vivo gaba accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland |
| url |
http://hdl.handle.net/20.500.12110/paper_00068993_v398_n2_p403_Rosenstein |
| work_keys_str_mv |
AT rosensteinre melatoninincreasesinvivogabaaccumulationinrathypothalamuscerebellumcerebralcortexandpinealgland AT cardinalidp melatoninincreasesinvivogabaaccumulationinrathypothalamuscerebellumcerebralcortexandpinealgland |
| _version_ |
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