Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes

The effect of several pineal methoxyindoles on 45Ca2+-uptake was examined in a crude synaptosome preparation from adult rat brains. 5-Methoxytryptol, 5-methoxytryptamine, melatonin and 6-chloromelatonin (10-8-10-6 M) depressed significantly the K+- stimulated increase in Ca2+-uptake, without affecti...

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Autores principales:	Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P.
Formato:	JOUR
Materias:	calcium uptake melatonin methoxyindoles pineal gland synaptosomes 5 methoxytryptamine 5 methoxytryptoline 6 chloromelatonin calcium calcium chloride ca 45 radioisotope serotonin animal cell animal experiment central nervous system endocrine system methoxyindole nervous system nonhuman pineal body rat synaptosome 5-Methoxytryptamine Animal Brain Calcium Female In Vitro Indoles Melatonin Pineal Gland Rats Rats, Inbred Strains Serotonin Support, Non-U.S. Gov't Synaptosomes
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00068993_v294_n1_p166_Vacas
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00068993_v294_n1_p166_Vacas
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spelling	todo:paper_00068993_v294_n1_p166_Vacas2023-10-03T14:05:21Z Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes Vacas, M.I. Keller Sarmiento, M.I. Cardinali, D.P. calcium uptake melatonin methoxyindoles pineal gland synaptosomes 5 methoxytryptamine 5 methoxytryptoline 6 chloromelatonin calcium calcium chloride ca 45 melatonin radioisotope serotonin animal cell animal experiment central nervous system endocrine system methoxyindole nervous system nonhuman pineal body rat synaptosome 5-Methoxytryptamine Animal Brain Calcium Female In Vitro Indoles Melatonin Pineal Gland Rats Rats, Inbred Strains Serotonin Support, Non-U.S. Gov't Synaptosomes The effect of several pineal methoxyindoles on 45Ca2+-uptake was examined in a crude synaptosome preparation from adult rat brains. 5-Methoxytryptol, 5-methoxytryptamine, melatonin and 6-chloromelatonin (10-8-10-6 M) depressed significantly the K+- stimulated increase in Ca2+-uptake, without affecting the basal, unstimulated Ca2+-uptake by synaptosomes. At 10-6 M concentration the following order of potency was found: 6-chloromelatonin ≥ 5-methoxytruptamine > 5-methoxytryptophol ≥ melatonin. Serotanin did not affect significantly either basal or stimulated Ca2+-uptake. © 1984. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00068993_v294_n1_p166_Vacas
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	calcium uptake melatonin methoxyindoles pineal gland synaptosomes 5 methoxytryptamine 5 methoxytryptoline 6 chloromelatonin calcium calcium chloride ca 45 melatonin radioisotope serotonin animal cell animal experiment central nervous system endocrine system methoxyindole nervous system nonhuman pineal body rat synaptosome 5-Methoxytryptamine Animal Brain Calcium Female In Vitro Indoles Melatonin Pineal Gland Rats Rats, Inbred Strains Serotonin Support, Non-U.S. Gov't Synaptosomes
spellingShingle	calcium uptake melatonin methoxyindoles pineal gland synaptosomes 5 methoxytryptamine 5 methoxytryptoline 6 chloromelatonin calcium calcium chloride ca 45 melatonin radioisotope serotonin animal cell animal experiment central nervous system endocrine system methoxyindole nervous system nonhuman pineal body rat synaptosome 5-Methoxytryptamine Animal Brain Calcium Female In Vitro Indoles Melatonin Pineal Gland Rats Rats, Inbred Strains Serotonin Support, Non-U.S. Gov't Synaptosomes Vacas, M.I. Keller Sarmiento, M.I. Cardinali, D.P. Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes
topic_facet	calcium uptake melatonin methoxyindoles pineal gland synaptosomes 5 methoxytryptamine 5 methoxytryptoline 6 chloromelatonin calcium calcium chloride ca 45 melatonin radioisotope serotonin animal cell animal experiment central nervous system endocrine system methoxyindole nervous system nonhuman pineal body rat synaptosome 5-Methoxytryptamine Animal Brain Calcium Female In Vitro Indoles Melatonin Pineal Gland Rats Rats, Inbred Strains Serotonin Support, Non-U.S. Gov't Synaptosomes
description	The effect of several pineal methoxyindoles on 45Ca2+-uptake was examined in a crude synaptosome preparation from adult rat brains. 5-Methoxytryptol, 5-methoxytryptamine, melatonin and 6-chloromelatonin (10-8-10-6 M) depressed significantly the K+- stimulated increase in Ca2+-uptake, without affecting the basal, unstimulated Ca2+-uptake by synaptosomes. At 10-6 M concentration the following order of potency was found: 6-chloromelatonin ≥ 5-methoxytruptamine > 5-methoxytryptophol ≥ melatonin. Serotanin did not affect significantly either basal or stimulated Ca2+-uptake. © 1984.
format	JOUR
author	Vacas, M.I. Keller Sarmiento, M.I. Cardinali, D.P.
author_facet	Vacas, M.I. Keller Sarmiento, M.I. Cardinali, D.P.
author_sort	Vacas, M.I.
title	Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes
title_short	Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes
title_full	Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes
title_fullStr	Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes
title_full_unstemmed	Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes
title_sort	pineal methoxyindoles depress calcium uptake by rat brain synaptosomes
url	http://hdl.handle.net/20.500.12110/paper_00068993_v294_n1_p166_Vacas
work_keys_str_mv	AT vacasmi pinealmethoxyindolesdepresscalciumuptakebyratbrainsynaptosomes AT kellersarmientomi pinealmethoxyindolesdepresscalciumuptakebyratbrainsynaptosomes AT cardinalidp pinealmethoxyindolesdepresscalciumuptakebyratbrainsynaptosomes
_version_	1782027324755017728

Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes

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