Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes

The influence of diabetes mellitus on brain pathology is increasingly recognized. Previous contributions of our laboratory demonstrated in models of type 1 diabetes (nonobese diabetic and streptozotocin (STZ)-treated mice), a marked astrogliosis and neurogenesis deficit in hippocampus and increased...

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Autores principales: Revsin, Y., Saravia, F., Roig, P., Lima, A., De Kloet, E.R., Homo-Delarche, F., De Nicola, A.F.
Formato: JOUR
Materias:
Apolipoprotein-E, Fos, Jun, NADPH-diaphorase
Astrocytes
Diabetes mellitus
Hippocampus
Neurodegeneration
Neurons
Streptozotocin
apolipoprotein E
gene product
molecular marker
protein c fos
protein c jun
reduced nicotinamide adenine dinucleotide phosphate dehydrogenase
streptozocin
animal experiment
animal model
animal tissue
article
brain cortex
brain region
cell activation
cell count
controlled study
dentate gyrus
enzyme activity
female
gene expression
gene mutation
genetic analysis
genetic linkage
hippocampus
insulin dependent diabetes mellitus
macroglia
mouse
nerve cell lesion
nonhuman
oxidative stress
priority journal
streptozocin diabetes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00068993_v1038_n1_p22_Revsin
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00068993_v1038_n1_p22_Revsin
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spelling todo:paper_00068993_v1038_n1_p22_Revsin2023-10-03T14:05:19Z Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes Revsin, Y. Saravia, F. Roig, P. Lima, A. De Kloet, E.R. Homo-Delarche, F. De Nicola, A.F. Apolipoprotein-E, Fos, Jun, NADPH-diaphorase Astrocytes Diabetes mellitus Hippocampus Neurodegeneration Neurons Streptozotocin apolipoprotein E gene product molecular marker protein c fos protein c jun reduced nicotinamide adenine dinucleotide phosphate dehydrogenase streptozocin animal experiment animal model animal tissue article brain cortex brain region cell activation cell count controlled study dentate gyrus enzyme activity female gene expression gene mutation genetic analysis genetic linkage hippocampus insulin dependent diabetes mellitus macroglia mouse nerve cell lesion nonhuman oxidative stress priority journal streptozocin diabetes The influence of diabetes mellitus on brain pathology is increasingly recognized. Previous contributions of our laboratory demonstrated in models of type 1 diabetes (nonobese diabetic and streptozotocin (STZ)-treated mice), a marked astrogliosis and neurogenesis deficit in hippocampus and increased expression of hypothalamic neuropeptides. In the present investigation, we further analyzed alterations of astroglia and neurons in the hippocampus of mice 1 month after STZ-induced diabetes. Results showed that these STZ-diabetic mice presented: (a) increased number of astrocytes positive for apolipoprotein-E (Apo-E), a marker of ongoing neuronal dysfunction; (b) abnormal expression of early gene products associated with neuronal activation, including a high number of Jun + neurons in CA1 and CA3 layers and dentate gyrus, and of Fos-expressing neurons in CA3 layer; (c) augmented activity of NADPH-diaphorase, linked to oxidative stress, in CA3 region. These data support the concept that uncontrolled diabetes leads to hippocampal pathology, which adjoin to changes in other brain structures such as hypothalamus and cerebral cortex. © 2005 Elsevier B.V. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00068993_v1038_n1_p22_Revsin
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Apolipoprotein-E, Fos, Jun, NADPH-diaphorase
Astrocytes
Diabetes mellitus
Hippocampus
Neurodegeneration
Neurons
Streptozotocin
apolipoprotein E
gene product
molecular marker
protein c fos
protein c jun
reduced nicotinamide adenine dinucleotide phosphate dehydrogenase
streptozocin
animal experiment
animal model
animal tissue
article
brain cortex
brain region
cell activation
cell count
controlled study
dentate gyrus
enzyme activity
female
gene expression
gene mutation
genetic analysis
genetic linkage
hippocampus
insulin dependent diabetes mellitus
macroglia
mouse
nerve cell lesion
nonhuman
oxidative stress
priority journal
streptozocin diabetes
spellingShingle Apolipoprotein-E, Fos, Jun, NADPH-diaphorase
Astrocytes
Diabetes mellitus
Hippocampus
Neurodegeneration
Neurons
Streptozotocin
apolipoprotein E
gene product
molecular marker
protein c fos
protein c jun
reduced nicotinamide adenine dinucleotide phosphate dehydrogenase
streptozocin
animal experiment
animal model
animal tissue
article
brain cortex
brain region
cell activation
cell count
controlled study
dentate gyrus
enzyme activity
female
gene expression
gene mutation
genetic analysis
genetic linkage
hippocampus
insulin dependent diabetes mellitus
macroglia
mouse
nerve cell lesion
nonhuman
oxidative stress
priority journal
streptozocin diabetes
Revsin, Y.
Saravia, F.
Roig, P.
Lima, A.
De Kloet, E.R.
Homo-Delarche, F.
De Nicola, A.F.
Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes
topic_facet Apolipoprotein-E, Fos, Jun, NADPH-diaphorase
Astrocytes
Diabetes mellitus
Hippocampus
Neurodegeneration
Neurons
Streptozotocin
apolipoprotein E
gene product
molecular marker
protein c fos
protein c jun
reduced nicotinamide adenine dinucleotide phosphate dehydrogenase
streptozocin
animal experiment
animal model
animal tissue
article
brain cortex
brain region
cell activation
cell count
controlled study
dentate gyrus
enzyme activity
female
gene expression
gene mutation
genetic analysis
genetic linkage
hippocampus
insulin dependent diabetes mellitus
macroglia
mouse
nerve cell lesion
nonhuman
oxidative stress
priority journal
streptozocin diabetes
description The influence of diabetes mellitus on brain pathology is increasingly recognized. Previous contributions of our laboratory demonstrated in models of type 1 diabetes (nonobese diabetic and streptozotocin (STZ)-treated mice), a marked astrogliosis and neurogenesis deficit in hippocampus and increased expression of hypothalamic neuropeptides. In the present investigation, we further analyzed alterations of astroglia and neurons in the hippocampus of mice 1 month after STZ-induced diabetes. Results showed that these STZ-diabetic mice presented: (a) increased number of astrocytes positive for apolipoprotein-E (Apo-E), a marker of ongoing neuronal dysfunction; (b) abnormal expression of early gene products associated with neuronal activation, including a high number of Jun + neurons in CA1 and CA3 layers and dentate gyrus, and of Fos-expressing neurons in CA3 layer; (c) augmented activity of NADPH-diaphorase, linked to oxidative stress, in CA3 region. These data support the concept that uncontrolled diabetes leads to hippocampal pathology, which adjoin to changes in other brain structures such as hypothalamus and cerebral cortex. © 2005 Elsevier B.V. All rights reserved.
format JOUR
author Revsin, Y.
Saravia, F.
Roig, P.
Lima, A.
De Kloet, E.R.
Homo-Delarche, F.
De Nicola, A.F.
author_facet Revsin, Y.
Saravia, F.
Roig, P.
Lima, A.
De Kloet, E.R.
Homo-Delarche, F.
De Nicola, A.F.
author_sort Revsin, Y.
title Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes
title_short Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes
title_full Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes
title_fullStr Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes
title_full_unstemmed Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes
title_sort neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes
url http://hdl.handle.net/20.500.12110/paper_00068993_v1038_n1_p22_Revsin
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