Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period

Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained...

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Autores principales: Soiza-Reilly, M., Fossati, M., Ibarra, G.R., Azcurra, J.M.
Formato: JOUR
Materias:
Basal ganglia
Critical period
D1 receptor
D2 receptor
Dopamine
Motor plasticity
Motor systems and sensorimotor integration
Rat striatum
dopamine 1 receptor
dopamine 2 receptor
isoprotein
messenger RNA
muscarinic receptor
animal experiment
animal tissue
article
binding site
circling behavior
controlled study
corpus striatum
learning
male
motor activity
nonhuman
ontogeny
perinatal period
priority journal
protein binding
protein expression
rat
synapse
training
Animals
Corpus Striatum
Critical Period (Psychology)
Gene Expression Regulation
Male
Motor Activity
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1
Receptors, Dopamine D2
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00068993_v1004_n1-2_p217_SoizaReilly
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_00068993_v1004_n1-2_p217_SoizaReilly2023-10-03T14:05:18Z Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period Soiza-Reilly, M. Fossati, M. Ibarra, G.R. Azcurra, J.M. Basal ganglia Critical period D1 receptor D2 receptor Dopamine Motor plasticity Motor systems and sensorimotor integration Rat striatum dopamine 1 receptor dopamine 2 receptor isoprotein messenger RNA muscarinic receptor animal experiment animal tissue article binding site circling behavior controlled study corpus striatum learning male motor activity nonhuman ontogeny perinatal period priority journal protein binding protein expression rat synapse training Animals Corpus Striatum Critical Period (Psychology) Gene Expression Regulation Male Motor Activity Rats Rats, Sprague-Dawley Receptors, Dopamine D1 Receptors, Dopamine D2 Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained rats showed a decrease of 40% in D2R binding sites (p<0.01) and of 45% in the D2R mRNA expression which involve short (p<0.05) and long (p<0.01) isoforms. In contrast, D1R binding sites nor its mRNA expression levels were affected by training, indicating a differential synaptic refinement during this ontogenetically fixed period. © 2004 Elsevier B.V. All rights reserved. Fil:Soiza-Reilly, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fossati, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Azcurra, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00068993_v1004_n1-2_p217_SoizaReilly
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Basal ganglia
Critical period
D1 receptor
D2 receptor
Dopamine
Motor plasticity
Motor systems and sensorimotor integration
Rat striatum
dopamine 1 receptor
dopamine 2 receptor
isoprotein
messenger RNA
muscarinic receptor
animal experiment
animal tissue
article
binding site
circling behavior
controlled study
corpus striatum
learning
male
motor activity
nonhuman
ontogeny
perinatal period
priority journal
protein binding
protein expression
rat
synapse
training
Animals
Corpus Striatum
Critical Period (Psychology)
Gene Expression Regulation
Male
Motor Activity
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1
Receptors, Dopamine D2
spellingShingle Basal ganglia
Critical period
D1 receptor
D2 receptor
Dopamine
Motor plasticity
Motor systems and sensorimotor integration
Rat striatum
dopamine 1 receptor
dopamine 2 receptor
isoprotein
messenger RNA
muscarinic receptor
animal experiment
animal tissue
article
binding site
circling behavior
controlled study
corpus striatum
learning
male
motor activity
nonhuman
ontogeny
perinatal period
priority journal
protein binding
protein expression
rat
synapse
training
Animals
Corpus Striatum
Critical Period (Psychology)
Gene Expression Regulation
Male
Motor Activity
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1
Receptors, Dopamine D2
Soiza-Reilly, M.
Fossati, M.
Ibarra, G.R.
Azcurra, J.M.
Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period
topic_facet Basal ganglia
Critical period
D1 receptor
D2 receptor
Dopamine
Motor plasticity
Motor systems and sensorimotor integration
Rat striatum
dopamine 1 receptor
dopamine 2 receptor
isoprotein
messenger RNA
muscarinic receptor
animal experiment
animal tissue
article
binding site
circling behavior
controlled study
corpus striatum
learning
male
motor activity
nonhuman
ontogeny
perinatal period
priority journal
protein binding
protein expression
rat
synapse
training
Animals
Corpus Striatum
Critical Period (Psychology)
Gene Expression Regulation
Male
Motor Activity
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1
Receptors, Dopamine D2
description Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained rats showed a decrease of 40% in D2R binding sites (p<0.01) and of 45% in the D2R mRNA expression which involve short (p<0.05) and long (p<0.01) isoforms. In contrast, D1R binding sites nor its mRNA expression levels were affected by training, indicating a differential synaptic refinement during this ontogenetically fixed period. © 2004 Elsevier B.V. All rights reserved.
format JOUR
author Soiza-Reilly, M.
Fossati, M.
Ibarra, G.R.
Azcurra, J.M.
author_facet Soiza-Reilly, M.
Fossati, M.
Ibarra, G.R.
Azcurra, J.M.
author_sort Soiza-Reilly, M.
title Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period
title_short Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period
title_full Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period
title_fullStr Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period
title_full_unstemmed Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period
title_sort different dopamine d1 and d2 receptors expression after motor activity in the striatal critical period
url http://hdl.handle.net/20.500.12110/paper_00068993_v1004_n1-2_p217_SoizaReilly
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