Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi
Nifurtimox (NF) and benznidazole (BZ), drugs used in the treatment ofChagas' disease, did not inhibit protein biosynthesis in in vitro homologous cell-free systems isolated from Trypanosoma cruzi and Crithidia fasciculata; nevertheless, their addition to growing cultures caused polyribosomal de...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00062952_v38_n17_p2873_Gonzalez |
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todo:paper_00062952_v38_n17_p2873_Gonzalez2023-10-03T14:04:15Z Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi Gonzalez, N.S. Cazzulo, J.J. benznidazole diminazene aceturate nifurtimox quinapyramine suramin crithidia fasciculata nonhuman priority journal protein synthesis protein synthesis inhibition protozoon trypanosoma cruzi Animal Crithidia In Vitro Nifurtimox Nitrofurans Nitroimidazoles Proteins Trypanocidal Agents Trypanosoma cruzi Nifurtimox (NF) and benznidazole (BZ), drugs used in the treatment ofChagas' disease, did not inhibit protein biosynthesis in in vitro homologous cell-free systems isolated from Trypanosoma cruzi and Crithidia fasciculata; nevertheless, their addition to growing cultures caused polyribosomal depolymerization. On the other hand, Berenil®, Antrycide® and suramin, used against African trypanosomiasis, inhibited protein biosynthesis in vitro but did not affect ribosomal distribution, probably due to low permeability to the drugs. The results suggest that the inhibition by NF and BZ of protein synthesis, measured as [14C]leucine incorporation by other authors, is indirect, probably through inhibition of nucleic acid synthesis and energy metabolism. © 1989. Fil:Gonzalez, N.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00062952_v38_n17_p2873_Gonzalez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
benznidazole diminazene aceturate nifurtimox quinapyramine suramin crithidia fasciculata nonhuman priority journal protein synthesis protein synthesis inhibition protozoon trypanosoma cruzi Animal Crithidia In Vitro Nifurtimox Nitrofurans Nitroimidazoles Proteins Trypanocidal Agents Trypanosoma cruzi |
| spellingShingle |
benznidazole diminazene aceturate nifurtimox quinapyramine suramin crithidia fasciculata nonhuman priority journal protein synthesis protein synthesis inhibition protozoon trypanosoma cruzi Animal Crithidia In Vitro Nifurtimox Nitrofurans Nitroimidazoles Proteins Trypanocidal Agents Trypanosoma cruzi Gonzalez, N.S. Cazzulo, J.J. Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi |
| topic_facet |
benznidazole diminazene aceturate nifurtimox quinapyramine suramin crithidia fasciculata nonhuman priority journal protein synthesis protein synthesis inhibition protozoon trypanosoma cruzi Animal Crithidia In Vitro Nifurtimox Nitrofurans Nitroimidazoles Proteins Trypanocidal Agents Trypanosoma cruzi |
| description |
Nifurtimox (NF) and benznidazole (BZ), drugs used in the treatment ofChagas' disease, did not inhibit protein biosynthesis in in vitro homologous cell-free systems isolated from Trypanosoma cruzi and Crithidia fasciculata; nevertheless, their addition to growing cultures caused polyribosomal depolymerization. On the other hand, Berenil®, Antrycide® and suramin, used against African trypanosomiasis, inhibited protein biosynthesis in vitro but did not affect ribosomal distribution, probably due to low permeability to the drugs. The results suggest that the inhibition by NF and BZ of protein synthesis, measured as [14C]leucine incorporation by other authors, is indirect, probably through inhibition of nucleic acid synthesis and energy metabolism. © 1989. |
| format |
JOUR |
| author |
Gonzalez, N.S. Cazzulo, J.J. |
| author_facet |
Gonzalez, N.S. Cazzulo, J.J. |
| author_sort |
Gonzalez, N.S. |
| title |
Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi |
| title_short |
Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi |
| title_full |
Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi |
| title_fullStr |
Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi |
| title_full_unstemmed |
Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi |
| title_sort |
effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by trypanosoma cruzi |
| url |
http://hdl.handle.net/20.500.12110/paper_00062952_v38_n17_p2873_Gonzalez |
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