A Neurospora crassa morphological mutant showing reduced adenylate cyclase activity
A Neurospora crassa morphological mutation at the crisp locus is related to a low specific activity of adenylate cyclase. This observation was made in two different strains: FGSC No. 329 and FGSC No. 326, both carrying the crisp mutation (allele N. B 123). Crosses of these strains to others having t...
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| Autores principales: | , , |
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0006291X_v58_n4_p990_Terenzi |
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| Sumario: | A Neurospora crassa morphological mutation at the crisp locus is related to a low specific activity of adenylate cyclase. This observation was made in two different strains: FGSC No. 329 and FGSC No. 326, both carrying the crisp mutation (allele N. B 123). Crosses of these strains to others having the wild type allele yield isolates with the crisp phenotype all of them having low adenylate cyclase specific activity in crude extracts. The other phenotypes obtained showed wild type levels of specific activity. Addition of 3′, 5′ dibutyryl cyclic AMP to the FGSC No. 329 cultures increased four-fold mycelial growth rate and stimulated the formation of aerial hyphae. Simultaneously, uniform conidiation on the surface of the slant was inhibited by the cyclic AMP derivative. © 1974 Academic Press, Inc. |
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