On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate

Inhibition of E. coli growth by cyclic adenosine monophosphate is observed in wild type strains cultured in glucose as carbon source, but not in a cyclic AMP receptor protein deficient mutant. A deletion mutant of the adenylate cyclase gene requires cyclic adenosine monophosphate for optimal growth....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	De Robertis Jr., E.M., Judewicz, N.D., Torres, H.N.
Formato:	JOUR
Materias:	adenylate cyclase cyclic amp bacterium cell division cell growth escherichia coli growth in vitro study microorganism theoretical study Adenylate Cyclase Cell Division Culture Media Cyclic AMP Enzyme Induction Escherichia coli Galactose Galactosidases Glucose Glycerol Glycosides Mutation Nitrosoguanidines Receptors, Drug Spectrophotometry Sulfhydryl Compounds Thiamine Time Factors
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0006291X_v55_n3_p758_DeRobertisJr
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_0006291X_v55_n3_p758_DeRobertisJr
record_format	dspace
spelling	todo:paper_0006291X_v55_n3_p758_DeRobertisJr2023-10-03T14:04:06Z On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate De Robertis Jr., E.M. Judewicz, N.D. Torres, H.N. adenylate cyclase cyclic amp bacterium cell division cell growth escherichia coli growth in vitro study microorganism theoretical study Adenylate Cyclase Cell Division Culture Media Cyclic AMP Enzyme Induction Escherichia coli Galactose Galactosidases Glucose Glycerol Glycosides Mutation Nitrosoguanidines Receptors, Drug Spectrophotometry Sulfhydryl Compounds Thiamine Time Factors Inhibition of E. coli growth by cyclic adenosine monophosphate is observed in wild type strains cultured in glucose as carbon source, but not in a cyclic AMP receptor protein deficient mutant. A deletion mutant of the adenylate cyclase gene requires cyclic adenosine monophosphate for optimal growth. Using glucose as carbon source, 2 mM cyclic AMP promotes maximal rates of cell multiplication in this mutant; however higher concentrations of the nucleotide inhibit growth. Cell multiplication of wild type strains grown in glycerol is not affected by cyclic adenosine monophosphate. Nevertheless, in this carbon source the growth rate of the adenylate cyclase mutant is strongly inhibited by concentrations of this nucleotide beyond 0.1 mM. This suggests that growth inhibition by exogenous cyclic adenosine monophosphate is highly dependent on the intracellular levels of the nucleotide. © 1973. Fil:De Robertis Jr., E.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Judewicz, N.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Torres, H.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0006291X_v55_n3_p758_DeRobertisJr
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	adenylate cyclase cyclic amp bacterium cell division cell growth escherichia coli growth in vitro study microorganism theoretical study Adenylate Cyclase Cell Division Culture Media Cyclic AMP Enzyme Induction Escherichia coli Galactose Galactosidases Glucose Glycerol Glycosides Mutation Nitrosoguanidines Receptors, Drug Spectrophotometry Sulfhydryl Compounds Thiamine Time Factors
spellingShingle	adenylate cyclase cyclic amp bacterium cell division cell growth escherichia coli growth in vitro study microorganism theoretical study Adenylate Cyclase Cell Division Culture Media Cyclic AMP Enzyme Induction Escherichia coli Galactose Galactosidases Glucose Glycerol Glycosides Mutation Nitrosoguanidines Receptors, Drug Spectrophotometry Sulfhydryl Compounds Thiamine Time Factors De Robertis Jr., E.M. Judewicz, N.D. Torres, H.N. On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate
topic_facet	adenylate cyclase cyclic amp bacterium cell division cell growth escherichia coli growth in vitro study microorganism theoretical study Adenylate Cyclase Cell Division Culture Media Cyclic AMP Enzyme Induction Escherichia coli Galactose Galactosidases Glucose Glycerol Glycosides Mutation Nitrosoguanidines Receptors, Drug Spectrophotometry Sulfhydryl Compounds Thiamine Time Factors
description	Inhibition of E. coli growth by cyclic adenosine monophosphate is observed in wild type strains cultured in glucose as carbon source, but not in a cyclic AMP receptor protein deficient mutant. A deletion mutant of the adenylate cyclase gene requires cyclic adenosine monophosphate for optimal growth. Using glucose as carbon source, 2 mM cyclic AMP promotes maximal rates of cell multiplication in this mutant; however higher concentrations of the nucleotide inhibit growth. Cell multiplication of wild type strains grown in glycerol is not affected by cyclic adenosine monophosphate. Nevertheless, in this carbon source the growth rate of the adenylate cyclase mutant is strongly inhibited by concentrations of this nucleotide beyond 0.1 mM. This suggests that growth inhibition by exogenous cyclic adenosine monophosphate is highly dependent on the intracellular levels of the nucleotide. © 1973.
format	JOUR
author	De Robertis Jr., E.M. Judewicz, N.D. Torres, H.N.
author_facet	De Robertis Jr., E.M. Judewicz, N.D. Torres, H.N.
author_sort	De Robertis Jr., E.M.
title	On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate
title_short	On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate
title_full	On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate
title_fullStr	On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate
title_full_unstemmed	On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate
title_sort	on the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate
url	http://hdl.handle.net/20.500.12110/paper_0006291X_v55_n3_p758_DeRobertisJr
work_keys_str_mv	AT derobertisjrem onthecontrolmechanismofbacterialgrowthbycyclicadenosine35monophosphate AT judewicznd onthecontrolmechanismofbacterialgrowthbycyclicadenosine35monophosphate AT torreshn onthecontrolmechanismofbacterialgrowthbycyclicadenosine35monophosphate
_version_	1807319423829147648

On the control mechanism of bacterial growth by cyclic adenosine 3′, 5′-monophosphate

Ejemplares similares