13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7

The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of n...

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Detalles Bibliográficos
Autores principales: Resnicoff, M., Medrano, E.E.
Formato: JOUR
Materias:
growth factor
13 cis retinal
breast
breast tumor
cell strain mcf 7
dose response
drug mechanism
drug response
growth stimulation
human
human cell
pharmacokinetics
priority journal
protein synthesis
Breast Neoplasms
Cell Division
Cell Line
Cell Nucleus
Female
Human
Kinetics
Neoplasm Proteins
Nucleoproteins
Retinaldehyde
Retinoids
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0006291X_v143_n1_p309_Resnicoff
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of nuclear proteins in cronically treated cells. The cytoplasmic proteins and proteins released to the culture medium are transiently and oppositly modified. Moreover, cronic treated cells have growth advantages over the untreated counterparts in a clonogenic soft agar assay. © 1987.

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