13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7
The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of n...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0006291X_v143_n1_p309_Resnicoff |
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todo:paper_0006291X_v143_n1_p309_Resnicoff2023-10-03T14:03:39Z 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 Resnicoff, M. Medrano, E.E. growth factor 13 cis retinal breast breast tumor cell strain mcf 7 dose response drug mechanism drug response growth stimulation human human cell pharmacokinetics priority journal protein synthesis Breast Neoplasms Cell Division Cell Line Cell Nucleus Female Human Kinetics Neoplasm Proteins Nucleoproteins Retinaldehyde Retinoids Support, Non-U.S. Gov't The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of nuclear proteins in cronically treated cells. The cytoplasmic proteins and proteins released to the culture medium are transiently and oppositly modified. Moreover, cronic treated cells have growth advantages over the untreated counterparts in a clonogenic soft agar assay. © 1987. Fil:Resnicoff, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Medrano, E.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0006291X_v143_n1_p309_Resnicoff |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
growth factor 13 cis retinal breast breast tumor cell strain mcf 7 dose response drug mechanism drug response growth stimulation human human cell pharmacokinetics priority journal protein synthesis Breast Neoplasms Cell Division Cell Line Cell Nucleus Female Human Kinetics Neoplasm Proteins Nucleoproteins Retinaldehyde Retinoids Support, Non-U.S. Gov't |
| spellingShingle |
growth factor 13 cis retinal breast breast tumor cell strain mcf 7 dose response drug mechanism drug response growth stimulation human human cell pharmacokinetics priority journal protein synthesis Breast Neoplasms Cell Division Cell Line Cell Nucleus Female Human Kinetics Neoplasm Proteins Nucleoproteins Retinaldehyde Retinoids Support, Non-U.S. Gov't Resnicoff, M. Medrano, E.E. 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
| topic_facet |
growth factor 13 cis retinal breast breast tumor cell strain mcf 7 dose response drug mechanism drug response growth stimulation human human cell pharmacokinetics priority journal protein synthesis Breast Neoplasms Cell Division Cell Line Cell Nucleus Female Human Kinetics Neoplasm Proteins Nucleoproteins Retinaldehyde Retinoids Support, Non-U.S. Gov't |
| description |
The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of nuclear proteins in cronically treated cells. The cytoplasmic proteins and proteins released to the culture medium are transiently and oppositly modified. Moreover, cronic treated cells have growth advantages over the untreated counterparts in a clonogenic soft agar assay. © 1987. |
| format |
JOUR |
| author |
Resnicoff, M. Medrano, E.E. |
| author_facet |
Resnicoff, M. Medrano, E.E. |
| author_sort |
Resnicoff, M. |
| title |
13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
| title_short |
13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
| title_full |
13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
| title_fullStr |
13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
| title_full_unstemmed |
13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
| title_sort |
13-cis-retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells mcf-7 |
| url |
http://hdl.handle.net/20.500.12110/paper_0006291X_v143_n1_p309_Resnicoff |
| work_keys_str_mv |
AT resnicoffm 13cisretinalstimulatesproliferationandinducesintranuclearproteinaccumulationinthehumanmammarytumorcellsmcf7 AT medranoee 13cisretinalstimulatesproliferationandinducesintranuclearproteinaccumulationinthehumanmammarytumorcellsmcf7 |
| _version_ |
1807315000170119168 |