Cognitive functions in major depression and Parkinson disease

Objective: To investigate the importance of major depression in the production of cognitive deficits in patients with Parkinson disease (PD). Design: A comprehensive neuropsychological and psychiatric assessment was conducted in 19 patients with PD and major depression, 31 patients with PD without d...

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Detalles Bibliográficos
Autores principales: Kuzis, G., Sabe, L., Tiberti, C., Leiguarda, R., Starkstein, S.E.
Formato: JOUR
Materias:
adult
aged
article
attention
clinical article
cognitive defect
controlled study
depression
female
human
male
Parkinson disease
priority journal
verbal behavior
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00039942_v54_n8_p982_Kuzis
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00039942_v54_n8_p982_Kuzis
record_format dspace
spelling todo:paper_00039942_v54_n8_p982_Kuzis2023-10-03T13:57:08Z Cognitive functions in major depression and Parkinson disease Kuzis, G. Sabe, L. Tiberti, C. Leiguarda, R. Starkstein, S.E. adult aged article attention clinical article cognitive defect controlled study depression female human male Parkinson disease priority journal verbal behavior Objective: To investigate the importance of major depression in the production of cognitive deficits in patients with Parkinson disease (PD). Design: A comprehensive neuropsychological and psychiatric assessment was conducted in 19 patients with PD and major depression, 31 patients with PD without depression, 27 patients with major depression but without PD, and 12 age-comparable healthy controls. Setting: Outpatient clinic. Results: Patients with major depression (with or without PD) had significantly more severe cognitive deficits than both healthy controls and patients with PD without depression on tests of verbal fluency and auditory attention, while patients with PD and major depression had significantly more severe deficits on tasks of abstract reasoning and set alternation compared with the other 3 groups. Conclusions: Major depression in patients with PD is associated with significant deficits on specific cognitive tasks. While some of these deficits may be explained by the presence of major depression, frontal lobe- related cognitive impairments may result from an interaction between neuropathologic factors in PD and the mechanism of major depression. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00039942_v54_n8_p982_Kuzis
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic adult
aged
article
attention
clinical article
cognitive defect
controlled study
depression
female
human
male
Parkinson disease
priority journal
verbal behavior
spellingShingle adult
aged
article
attention
clinical article
cognitive defect
controlled study
depression
female
human
male
Parkinson disease
priority journal
verbal behavior
Kuzis, G.
Sabe, L.
Tiberti, C.
Leiguarda, R.
Starkstein, S.E.
Cognitive functions in major depression and Parkinson disease
topic_facet adult
aged
article
attention
clinical article
cognitive defect
controlled study
depression
female
human
male
Parkinson disease
priority journal
verbal behavior
description Objective: To investigate the importance of major depression in the production of cognitive deficits in patients with Parkinson disease (PD). Design: A comprehensive neuropsychological and psychiatric assessment was conducted in 19 patients with PD and major depression, 31 patients with PD without depression, 27 patients with major depression but without PD, and 12 age-comparable healthy controls. Setting: Outpatient clinic. Results: Patients with major depression (with or without PD) had significantly more severe cognitive deficits than both healthy controls and patients with PD without depression on tests of verbal fluency and auditory attention, while patients with PD and major depression had significantly more severe deficits on tasks of abstract reasoning and set alternation compared with the other 3 groups. Conclusions: Major depression in patients with PD is associated with significant deficits on specific cognitive tasks. While some of these deficits may be explained by the presence of major depression, frontal lobe- related cognitive impairments may result from an interaction between neuropathologic factors in PD and the mechanism of major depression.
format JOUR
author Kuzis, G.
Sabe, L.
Tiberti, C.
Leiguarda, R.
Starkstein, S.E.
author_facet Kuzis, G.
Sabe, L.
Tiberti, C.
Leiguarda, R.
Starkstein, S.E.
author_sort Kuzis, G.
title Cognitive functions in major depression and Parkinson disease
title_short Cognitive functions in major depression and Parkinson disease
title_full Cognitive functions in major depression and Parkinson disease
title_fullStr Cognitive functions in major depression and Parkinson disease
title_full_unstemmed Cognitive functions in major depression and Parkinson disease
title_sort cognitive functions in major depression and parkinson disease
url http://hdl.handle.net/20.500.12110/paper_00039942_v54_n8_p982_Kuzis
work_keys_str_mv AT kuzisg cognitivefunctionsinmajordepressionandparkinsondisease
AT sabel cognitivefunctionsinmajordepressionandparkinsondisease
AT tibertic cognitivefunctionsinmajordepressionandparkinsondisease
AT leiguardar cognitivefunctionsinmajordepressionandparkinsondisease
AT starksteinse cognitivefunctionsinmajordepressionandparkinsondisease
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