Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires province (Argentina)

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Fil: Espinosa, María Beatriz. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales (INBA). Buenos Aires, Argentina.

Detalles Bibliográficos
Autor principal: Espinosa, María Beatriz
Formato: article Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2013
Materias:
RODENTICIDES
RODENTS
VITAMIN K EPOXIDE REDUCTASE
ANTICOAGULANT AGENT
CYTOCHROM P450 4F18
CYTOCHROME P450
OXIDOREDUCTASE
RODENTICIDE
UNCLASSIFIED DRUG
VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1
ARGENTINA
DRUG EFFICACY
EXON
GENE INTERACTION
GENE MUTATION
GENETIC VARIABILITY
MOUSE
MUS MUSCULUS
NONHUMAN
NUCLEOTIDE SEQUENCE
PEST CONTROL
Acceso en línea:http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2013espinosa
Aporte de:
FAUBA Digital - Facultad de Agronomía (UBA) de Universidad de Buenos Aires
id snrd:2013espinosa
record_format dspace
spelling snrd:2013espinosa2021-10-15T16:56:07Z 1001160 Buenos Aires (province) Espinosa, María Beatriz 2013 Fil: Espinosa, María Beatriz. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales (INBA). Buenos Aires, Argentina. The relationship between anticoagulant rodenticides and the gene for vitamin K epoxide reductase has been extensively studied The significance of mutations in Vkorc1 on the degree of response to anticoagulants is controversial. The implication of the VKORC1 function in pest control drives the attention to a wide range of factors that may be influencing the resistance to rodenticides, an issue that will be discussed in this article. Anticoagulants are used as rodenticides as well as to improve human health. The interactions between VKORC1 and CYP4F18 (cytochrome P450) are complex. It is likely that the coagulation response may be due to a diverse expression of the Vkorc1 gene and its interaction with the expression of Cyp4f18, and to the polymorphisms present in both genes. We analyzed the presence of polymorphisms (especially the presence of mutations that produce substitutions of Tyr139Cys and Leu128Ser) in Vkorc1 of the genome of Mus musculus belonging to local wild populations living in farms. The animals studied were from areas in which rodenticide anticoagulants (ej. bromadiolone) are commonly used as pest control. None of the studied mice showed any signs of anticoagulant resistance-related mutations in the Vkorc1 gene. This study will enable a proper selection of the rodenticide method for pest control in local areas. application/pdf issn:1666-0390 http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2013espinosa eng info:eu-repo/semantics/openAccess openAccess http://ri.agro.uba.ar/greenstone3/library/page/biblioteca#section4 BAG - Journal of Basic and Applied Genetics Vol.24, no.1 27-31 http://www.sag.org.ar/ RODENTICIDES RODENTS VITAMIN K EPOXIDE REDUCTASE ANTICOAGULANT AGENT CYTOCHROM P450 4F18 CYTOCHROME P450 OXIDOREDUCTASE RODENTICIDE UNCLASSIFIED DRUG VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1 ARGENTINA DRUG EFFICACY EXON GENE INTERACTION GENE MUTATION GENETIC VARIABILITY MOUSE MUS MUSCULUS NONHUMAN NUCLEOTIDE SEQUENCE PEST CONTROL Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires province (Argentina) article info:eu-repo/semantics/article info:ar-repo/semantics/artículo publishedVersion info:eu-repo/semantics/publishedVersion
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-140
collection FAUBA Digital - Facultad de Agronomía (UBA)
language Inglés
orig_language_str_mv eng
topic RODENTICIDES
RODENTS
VITAMIN K EPOXIDE REDUCTASE
ANTICOAGULANT AGENT
CYTOCHROM P450 4F18
CYTOCHROME P450
OXIDOREDUCTASE
RODENTICIDE
UNCLASSIFIED DRUG
VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1
ARGENTINA
DRUG EFFICACY
EXON
GENE INTERACTION
GENE MUTATION
GENETIC VARIABILITY
MOUSE
MUS MUSCULUS
NONHUMAN
NUCLEOTIDE SEQUENCE
PEST CONTROL
spellingShingle RODENTICIDES
RODENTS
VITAMIN K EPOXIDE REDUCTASE
ANTICOAGULANT AGENT
CYTOCHROM P450 4F18
CYTOCHROME P450
OXIDOREDUCTASE
RODENTICIDE
UNCLASSIFIED DRUG
VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1
ARGENTINA
DRUG EFFICACY
EXON
GENE INTERACTION
GENE MUTATION
GENETIC VARIABILITY
MOUSE
MUS MUSCULUS
NONHUMAN
NUCLEOTIDE SEQUENCE
PEST CONTROL
Espinosa, María Beatriz
Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires province (Argentina)
topic_facet RODENTICIDES
RODENTS
VITAMIN K EPOXIDE REDUCTASE
ANTICOAGULANT AGENT
CYTOCHROM P450 4F18
CYTOCHROME P450
OXIDOREDUCTASE
RODENTICIDE
UNCLASSIFIED DRUG
VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1
ARGENTINA
DRUG EFFICACY
EXON
GENE INTERACTION
GENE MUTATION
GENETIC VARIABILITY
MOUSE
MUS MUSCULUS
NONHUMAN
NUCLEOTIDE SEQUENCE
PEST CONTROL
description Fil: Espinosa, María Beatriz. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales (INBA). Buenos Aires, Argentina.
format article
Artículo
Artículo
publishedVersion
publishedVersion
author Espinosa, María Beatriz
author_facet Espinosa, María Beatriz
author_sort Espinosa, María Beatriz
title Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires province (Argentina)
title_short Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires province (Argentina)
title_full Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires province (Argentina)
title_fullStr Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires province (Argentina)
title_full_unstemmed Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires province (Argentina)
title_sort efficacy of anticoagulant drugs as rodenticides and genetic variation on vkorc1 of mus musculus from buenos aires province (argentina)
publishDate 2013
url http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2013espinosa
work_keys_str_mv AT espinosamariabeatriz efficacyofanticoagulantdrugsasrodenticidesandgeneticvariationonvkorc1ofmusmusculusfrombuenosairesprovinceargentina
_version_ 1827450743935729664

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