Mean field strategies induce unrealistic non-linearities in calcium puffs

Mean field models are often useful approximations to biological systems, but sometimes, they can yield misleading results. In this work, we compare mean field approaches with stochastic models of intracellular calcium release. In particular, we concentrate on calcium signals generated by the concert...

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Autores principales: Solovey, G., Fraiman, D., Dawson, S.P.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2011
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Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1664042X_v2AUG_n_p_Solovey
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spelling paperaa:paper_1664042X_v2AUG_n_p_Solovey2023-06-12T16:50:53Z Mean field strategies induce unrealistic non-linearities in calcium puffs Front. Physiol. 2011;2 AUG Solovey, G. Fraiman, D. Dawson, S.P. Calcium signals Mean field model Puffs Stochastic model Mean field models are often useful approximations to biological systems, but sometimes, they can yield misleading results. In this work, we compare mean field approaches with stochastic models of intracellular calcium release. In particular, we concentrate on calcium signals generated by the concerted opening of several clustered channels (calcium puffs). To this end we simulate calcium puffs numerically and then try to reproduce features of the resulting calcium distribution using mean field models were all the channels open and close simultaneously. We show that an unrealistic non-linear relationship between the current and the number of open channels is needed to reproduce the simulated puffs. Furthermore, a single channel current which is five times smaller than the one of the stochastic simulations is also needed. Our study sheds light on the importance of the stochastic kinetics of the calcium release channel activity to estimate the release fluxes. © 2011 Solovey, Fraiman and Dawson. Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_1664042X_v2AUG_n_p_Solovey
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language Inglés
orig_language_str_mv eng
topic Calcium signals
Mean field model
Puffs
Stochastic model
spellingShingle Calcium signals
Mean field model
Puffs
Stochastic model
Solovey, G.
Fraiman, D.
Dawson, S.P.
Mean field strategies induce unrealistic non-linearities in calcium puffs
topic_facet Calcium signals
Mean field model
Puffs
Stochastic model
description Mean field models are often useful approximations to biological systems, but sometimes, they can yield misleading results. In this work, we compare mean field approaches with stochastic models of intracellular calcium release. In particular, we concentrate on calcium signals generated by the concerted opening of several clustered channels (calcium puffs). To this end we simulate calcium puffs numerically and then try to reproduce features of the resulting calcium distribution using mean field models were all the channels open and close simultaneously. We show that an unrealistic non-linear relationship between the current and the number of open channels is needed to reproduce the simulated puffs. Furthermore, a single channel current which is five times smaller than the one of the stochastic simulations is also needed. Our study sheds light on the importance of the stochastic kinetics of the calcium release channel activity to estimate the release fluxes. © 2011 Solovey, Fraiman and Dawson.
format Artículo
Artículo
publishedVersion
author Solovey, G.
Fraiman, D.
Dawson, S.P.
author_facet Solovey, G.
Fraiman, D.
Dawson, S.P.
author_sort Solovey, G.
title Mean field strategies induce unrealistic non-linearities in calcium puffs
title_short Mean field strategies induce unrealistic non-linearities in calcium puffs
title_full Mean field strategies induce unrealistic non-linearities in calcium puffs
title_fullStr Mean field strategies induce unrealistic non-linearities in calcium puffs
title_full_unstemmed Mean field strategies induce unrealistic non-linearities in calcium puffs
title_sort mean field strategies induce unrealistic non-linearities in calcium puffs
publishDate 2011
url http://hdl.handle.net/20.500.12110/paper_1664042X_v2AUG_n_p_Solovey
work_keys_str_mv AT soloveyg meanfieldstrategiesinduceunrealisticnonlinearitiesincalciumpuffs
AT fraimand meanfieldstrategiesinduceunrealisticnonlinearitiesincalciumpuffs
AT dawsonsp meanfieldstrategiesinduceunrealisticnonlinearitiesincalciumpuffs
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