Novel processing in a mammalian nuclear 28S pre-rRNA: Tissue-specific elimination of an 'intron' bearing a hidden break site

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Splitting and apparent splicing of ribosomal RNA, both previously unknown in vertebrates, were found in rodents of the genus Ctenomys. Instead of being formed by a single molecule of 4.4 kb, 28S rRNA is split in two molecules of 2.6 and 1.8 kb. A hidden break, mapping within a 106 bp 'intron�...

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Detalles Bibliográficos
Autores principales: Melen, G.J., Pesce, C.G., Rossi, M.S., Kornblihtt, A.R.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 1999
Materias:
Mammalian cells
Ribosomal RNA processing
RNA 28s
RNA precursor
animal tissue
article
fibroblast culture
heart
intron
liver
lung
male
nonhuman
priority journal
RNA cleavage
RNA processing
rodent
spleen
testis
tissue specificity
Animals
Base Sequence
Blotting, Northern
Cells, Cultured
Electrophoresis, Polyacrylamide Gel
Evolution, Molecular
Introns
Male
Mice
Models, Genetic
Molecular Sequence Data
Molecular Weight
Nucleic Acid Conformation
Organ Specificity
Rats
Repetitive Sequences, Nucleic Acid
RNA Precursors
RNA Splicing
RNA, Ribosomal, 28S
Rodentia
Testis
Thermodynamics
Animalia
Ctenomys
Mammalia
Vertebrata
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02614189_v18_n11_p3107_Melen
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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