Behavioral tagging is a general mechanism of long-term memory formation
In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that...
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paperaa:paper_00278424_v106_n34_p14599_Ballarini2023-06-12T16:45:16Z Behavioral tagging is a general mechanism of long-term memory formation Proc. Natl. Acad. Sci. U. S. A. 2009;106(34):14599-14604 Ballarini, F. Moncada, D. Martinez, M.C. Alen, N. Viola, H. Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Hippocampus Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that in rats subjected to weak training protocols that induce solely short term memory (STM), long term memory (LTM) is promoted and formed only if training sessions took place in contingence with a novel, but not familiar, experience occurring during a critical time window around training. This process requires newly synthesized proteins induced by novelty and reveals a general mechanism of LTM formation that begins with the setting of a "learning tag" established by a weak training. These findings represent the first comprehensive set of evidences indicating the existence of a behavioral tagging process that in analogy to the synaptic tagging and capture process, need the creation of a transient, protein synthesis-independent, and input specific tag. Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alen, N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00278424_v106_n34_p14599_Ballarini |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
language |
Inglés |
orig_language_str_mv |
eng |
topic |
Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Hippocampus Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus |
spellingShingle |
Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Hippocampus Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus Ballarini, F. Moncada, D. Martinez, M.C. Alen, N. Viola, H. Behavioral tagging is a general mechanism of long-term memory formation |
topic_facet |
Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Hippocampus Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus |
description |
In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that in rats subjected to weak training protocols that induce solely short term memory (STM), long term memory (LTM) is promoted and formed only if training sessions took place in contingence with a novel, but not familiar, experience occurring during a critical time window around training. This process requires newly synthesized proteins induced by novelty and reveals a general mechanism of LTM formation that begins with the setting of a "learning tag" established by a weak training. These findings represent the first comprehensive set of evidences indicating the existence of a behavioral tagging process that in analogy to the synaptic tagging and capture process, need the creation of a transient, protein synthesis-independent, and input specific tag. |
format |
Artículo Artículo publishedVersion |
author |
Ballarini, F. Moncada, D. Martinez, M.C. Alen, N. Viola, H. |
author_facet |
Ballarini, F. Moncada, D. Martinez, M.C. Alen, N. Viola, H. |
author_sort |
Ballarini, F. |
title |
Behavioral tagging is a general mechanism of long-term memory formation |
title_short |
Behavioral tagging is a general mechanism of long-term memory formation |
title_full |
Behavioral tagging is a general mechanism of long-term memory formation |
title_fullStr |
Behavioral tagging is a general mechanism of long-term memory formation |
title_full_unstemmed |
Behavioral tagging is a general mechanism of long-term memory formation |
title_sort |
behavioral tagging is a general mechanism of long-term memory formation |
publishDate |
2009 |
url |
http://hdl.handle.net/20.500.12110/paper_00278424_v106_n34_p14599_Ballarini |
work_keys_str_mv |
AT ballarinif behavioraltaggingisageneralmechanismoflongtermmemoryformation AT moncadad behavioraltaggingisageneralmechanismoflongtermmemoryformation AT martinezmc behavioraltaggingisageneralmechanismoflongtermmemoryformation AT alenn behavioraltaggingisageneralmechanismoflongtermmemoryformation AT violah behavioraltaggingisageneralmechanismoflongtermmemoryformation |
_version_ |
1769810021144592384 |