Influence of the strain of rats on the induction of hexachlorobenzene induced porphyria
1. 1. The present work undertakes a comparative study on the hexachlorobenzene (HCB) porphyria induction in female rats of Wistar and CHBBTHOM strains. The purpose was to characterize the CHBBTHOM strain with respect to the haem metabolic pathway, its regulatory mechanisms and its response to foreig...
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| Formato: | Artículo publishedVersion |
| Lenguaje: | Inglés |
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1989
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0020711X_v21_n4_p377_WainstokdeCalmanovici |
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paperaa:paper_0020711X_v21_n4_p377_WainstokdeCalmanovici2023-06-12T16:42:14Z Influence of the strain of rats on the induction of hexachlorobenzene induced porphyria Int. J. Biochem. 1989;21(4):377-381 Wainstok de Calmanovici, R. Billi de Catabbi, S.C. Aldonatti, C.A. San Martin de Viale, L.C. 5 aminolevulinate synthase aminolevulinic acid heme hexachlorobenzene porphobilinogen porphyrin uroporphyrinogen decarboxylase xenobiotic agent animal cell animal experiment animal model female hepatic porphyria iron liver level nonhuman oral drug administration rat regulatory mechanism strain difference urinary excretion 5-Aminolevulinate Synthetase Animal Carboxy-Lyases Chlorobenzenes Comparative Study Female Hexachlorobenzene Iron Liver Liver Diseases Porphyria Porphyrins Rats Rats, Inbred Strains Species Specificity Support, Non-U.S. Gov't 1. 1. The present work undertakes a comparative study on the hexachlorobenzene (HCB) porphyria induction in female rats of Wistar and CHBBTHOM strains. The purpose was to characterize the CHBBTHOM strain with respect to the haem metabolic pathway, its regulatory mechanisms and its response to foreign drugs. 2. 2. After 7 weeks of treatment it was observed that the hepatic porphyrins increased 140 times, ALA-synthase 4 times and PCL was 73% inhibited in the Wistar strain. 3. 3. On the other hand the animals of CHBBTHOM strain showed lesser alteration on these parameters; hepatic porphyrins increased only 3-fold, ALA-synthase 1.7-fold and PCL was only 22% inhibited. 4. 4. Total iron liver content was nearly equal in both strains of rats. 5. 5. The results obtained would indicate that the lower susceptibility of the CHBBTHOM strain to acquire porphyria does not seem to be due to either: (1) congenital alterations of any parameters of the haem metabolic pathway, since the behaviour of normal animals from both strains was similar; or (2) a lower hepatic iron content in such animals. 6. 6. These findings would suggest that the differential response to HCB to this strain would be looked for in another metabolic pathway, such as that involved in the metabolization process of the toxic. © 1989. Fil:Wainstok de Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Billi de Catabbi, S.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martin de Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1989 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0020711X_v21_n4_p377_WainstokdeCalmanovici |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
5 aminolevulinate synthase aminolevulinic acid heme hexachlorobenzene porphobilinogen porphyrin uroporphyrinogen decarboxylase xenobiotic agent animal cell animal experiment animal model female hepatic porphyria iron liver level nonhuman oral drug administration rat regulatory mechanism strain difference urinary excretion 5-Aminolevulinate Synthetase Animal Carboxy-Lyases Chlorobenzenes Comparative Study Female Hexachlorobenzene Iron Liver Liver Diseases Porphyria Porphyrins Rats Rats, Inbred Strains Species Specificity Support, Non-U.S. Gov't |
| spellingShingle |
5 aminolevulinate synthase aminolevulinic acid heme hexachlorobenzene porphobilinogen porphyrin uroporphyrinogen decarboxylase xenobiotic agent animal cell animal experiment animal model female hepatic porphyria iron liver level nonhuman oral drug administration rat regulatory mechanism strain difference urinary excretion 5-Aminolevulinate Synthetase Animal Carboxy-Lyases Chlorobenzenes Comparative Study Female Hexachlorobenzene Iron Liver Liver Diseases Porphyria Porphyrins Rats Rats, Inbred Strains Species Specificity Support, Non-U.S. Gov't Wainstok de Calmanovici, R. Billi de Catabbi, S.C. Aldonatti, C.A. San Martin de Viale, L.C. Influence of the strain of rats on the induction of hexachlorobenzene induced porphyria |
| topic_facet |
5 aminolevulinate synthase aminolevulinic acid heme hexachlorobenzene porphobilinogen porphyrin uroporphyrinogen decarboxylase xenobiotic agent animal cell animal experiment animal model female hepatic porphyria iron liver level nonhuman oral drug administration rat regulatory mechanism strain difference urinary excretion 5-Aminolevulinate Synthetase Animal Carboxy-Lyases Chlorobenzenes Comparative Study Female Hexachlorobenzene Iron Liver Liver Diseases Porphyria Porphyrins Rats Rats, Inbred Strains Species Specificity Support, Non-U.S. Gov't |
| description |
1. 1. The present work undertakes a comparative study on the hexachlorobenzene (HCB) porphyria induction in female rats of Wistar and CHBBTHOM strains. The purpose was to characterize the CHBBTHOM strain with respect to the haem metabolic pathway, its regulatory mechanisms and its response to foreign drugs. 2. 2. After 7 weeks of treatment it was observed that the hepatic porphyrins increased 140 times, ALA-synthase 4 times and PCL was 73% inhibited in the Wistar strain. 3. 3. On the other hand the animals of CHBBTHOM strain showed lesser alteration on these parameters; hepatic porphyrins increased only 3-fold, ALA-synthase 1.7-fold and PCL was only 22% inhibited. 4. 4. Total iron liver content was nearly equal in both strains of rats. 5. 5. The results obtained would indicate that the lower susceptibility of the CHBBTHOM strain to acquire porphyria does not seem to be due to either: (1) congenital alterations of any parameters of the haem metabolic pathway, since the behaviour of normal animals from both strains was similar; or (2) a lower hepatic iron content in such animals. 6. 6. These findings would suggest that the differential response to HCB to this strain would be looked for in another metabolic pathway, such as that involved in the metabolization process of the toxic. © 1989. |
| format |
Artículo Artículo publishedVersion |
| author |
Wainstok de Calmanovici, R. Billi de Catabbi, S.C. Aldonatti, C.A. San Martin de Viale, L.C. |
| author_facet |
Wainstok de Calmanovici, R. Billi de Catabbi, S.C. Aldonatti, C.A. San Martin de Viale, L.C. |
| author_sort |
Wainstok de Calmanovici, R. |
| title |
Influence of the strain of rats on the induction of hexachlorobenzene induced porphyria |
| title_short |
Influence of the strain of rats on the induction of hexachlorobenzene induced porphyria |
| title_full |
Influence of the strain of rats on the induction of hexachlorobenzene induced porphyria |
| title_fullStr |
Influence of the strain of rats on the induction of hexachlorobenzene induced porphyria |
| title_full_unstemmed |
Influence of the strain of rats on the induction of hexachlorobenzene induced porphyria |
| title_sort |
influence of the strain of rats on the induction of hexachlorobenzene induced porphyria |
| publishDate |
1989 |
| url |
http://hdl.handle.net/20.500.12110/paper_0020711X_v21_n4_p377_WainstokdeCalmanovici |
| work_keys_str_mv |
AT wainstokdecalmanovicir influenceofthestrainofratsontheinductionofhexachlorobenzeneinducedporphyria AT billidecatabbisc influenceofthestrainofratsontheinductionofhexachlorobenzeneinducedporphyria AT aldonattica influenceofthestrainofratsontheinductionofhexachlorobenzeneinducedporphyria AT sanmartindevialelc influenceofthestrainofratsontheinductionofhexachlorobenzeneinducedporphyria |
| _version_ |
1769810077929177088 |