Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins

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1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decr...

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Detalles Bibliográficos
Autores principales: Del C. Batlle, A.M., De Salamanca, R.E., Chinarro, S., Afonso, S.G., Stella, A.M.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 1986
Materias:
porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986.

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