Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins

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1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decr...

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Autores principales: Del C. Batlle, A.M., De Salamanca, R.E., Chinarro, S., Afonso, S.G., Stella, A.M.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 1986
Materias:
porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling paperaa:paper_0020711X_v18_n2_p143_DelCBatlle2023-06-12T16:42:12Z Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins Int. J. Biochem. 1986;18(2):143-147 Del C. Batlle, A.M. De Salamanca, R.E. Chinarro, S. Afonso, S.G. Stella, A.M. porphyrin uroporphyrinogen decarboxylase blood and hemopoietic system enzyme inactivation erythrocyte human human cell photoactivation Carboxy-Lyases Erythrocytes Humans Kinetics Photolysis Porphyrins Thermodynamics Ultraviolet Rays Uroporphyrinogen Decarboxylase 1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986. Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1986 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language Inglés
orig_language_str_mv eng
topic porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
spellingShingle porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
Del C. Batlle, A.M.
De Salamanca, R.E.
Chinarro, S.
Afonso, S.G.
Stella, A.M.
Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
topic_facet porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
description 1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986.
format Artículo
Artículo
publishedVersion
author Del C. Batlle, A.M.
De Salamanca, R.E.
Chinarro, S.
Afonso, S.G.
Stella, A.M.
author_facet Del C. Batlle, A.M.
De Salamanca, R.E.
Chinarro, S.
Afonso, S.G.
Stella, A.M.
author_sort Del C. Batlle, A.M.
title Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_short Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_full Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_fullStr Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_full_unstemmed Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_sort photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
publishDate 1986
url http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle
work_keys_str_mv AT delcbatlleam photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins
AT desalamancare photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins
AT chinarros photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins
AT afonsosg photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins
AT stellaam photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins
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