p53 at the crossroads between stress response signaling and tumorigenesis: From molecular mechanisms to therapeutic opportunities

The p53 tumor suppressor is a transcription factor that integrates signals from numerous stress-activated signaling pathways and regulates the expression of specific target genes. p53 activation triggers a variety of cellular responses that ensure tumor suppression, including cell cycle arrest, apop...

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Detalles Bibliográficos
Autores principales:	Giono, Luciana Eugenia, Ladelfa, María Fátima
Publicado:	2015
Materias:	Apoptosis Cancer Cell cycle Cell signaling DNA damage Metabolism Mutation Oncogene p53 Senescence Therapy Tumor suppressor
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97894017_v_n_p51_Giono http://hdl.handle.net/20.500.12110/paper_97894017_v_n_p51_Giono
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_97894017_v_n_p51_Giono
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spelling	paper:paper_97894017_v_n_p51_Giono2023-06-08T16:39:11Z p53 at the crossroads between stress response signaling and tumorigenesis: From molecular mechanisms to therapeutic opportunities Giono, Luciana Eugenia Ladelfa, María Fátima Apoptosis Cancer Cell cycle Cell signaling DNA damage Metabolism Mutation Oncogene p53 Senescence Therapy Tumor suppressor The p53 tumor suppressor is a transcription factor that integrates signals from numerous stress-activated signaling pathways and regulates the expression of specific target genes. p53 activation triggers a variety of cellular responses that ensure tumor suppression, including cell cycle arrest, apoptosis and senescence. In addition, p53 tumor suppressive activity also involves the maintenance of cellular homeostasis through the regulation of metabolic pathways and the protection of stemness. Mutation of p53 protein or inactivation of the p53 pathway is the most frequent alteration found in human cancer. Loss of p53 function leads to tumorigenesis and is associated with poor prognosis and therapy resistance in cancer patients. Moreover, mutant p53 often exhibits gain of function activities that contribute to the tumoral phenotype. Over 30 years of basic research on p53 structure and function have placed p53 at the center of cancer investigation. Numerous cellular and mouse models have demonstrated that restoration of p53 function may stop tumor progression or even promote tumor regression. Now, these observations lead to the development of multiple anti-cancer therapeutic strategies that rely on activation of wild-type p53 or reactivation of mutant p53, as well as other p53-based approaches. Rational drug design and functional screenings have allowed for the identification of small molecule compounds, some of which are currently being tested in clinical trials. © Springer Science+Business Media Dordrecht 2015. Fil:Giono, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ladelfa, M.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97894017_v_n_p51_Giono http://hdl.handle.net/20.500.12110/paper_97894017_v_n_p51_Giono
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Apoptosis Cancer Cell cycle Cell signaling DNA damage Metabolism Mutation Oncogene p53 Senescence Therapy Tumor suppressor
spellingShingle	Apoptosis Cancer Cell cycle Cell signaling DNA damage Metabolism Mutation Oncogene p53 Senescence Therapy Tumor suppressor Giono, Luciana Eugenia Ladelfa, María Fátima p53 at the crossroads between stress response signaling and tumorigenesis: From molecular mechanisms to therapeutic opportunities
topic_facet	Apoptosis Cancer Cell cycle Cell signaling DNA damage Metabolism Mutation Oncogene p53 Senescence Therapy Tumor suppressor
description	The p53 tumor suppressor is a transcription factor that integrates signals from numerous stress-activated signaling pathways and regulates the expression of specific target genes. p53 activation triggers a variety of cellular responses that ensure tumor suppression, including cell cycle arrest, apoptosis and senescence. In addition, p53 tumor suppressive activity also involves the maintenance of cellular homeostasis through the regulation of metabolic pathways and the protection of stemness. Mutation of p53 protein or inactivation of the p53 pathway is the most frequent alteration found in human cancer. Loss of p53 function leads to tumorigenesis and is associated with poor prognosis and therapy resistance in cancer patients. Moreover, mutant p53 often exhibits gain of function activities that contribute to the tumoral phenotype. Over 30 years of basic research on p53 structure and function have placed p53 at the center of cancer investigation. Numerous cellular and mouse models have demonstrated that restoration of p53 function may stop tumor progression or even promote tumor regression. Now, these observations lead to the development of multiple anti-cancer therapeutic strategies that rely on activation of wild-type p53 or reactivation of mutant p53, as well as other p53-based approaches. Rational drug design and functional screenings have allowed for the identification of small molecule compounds, some of which are currently being tested in clinical trials. © Springer Science+Business Media Dordrecht 2015.
author	Giono, Luciana Eugenia Ladelfa, María Fátima
author_facet	Giono, Luciana Eugenia Ladelfa, María Fátima
author_sort	Giono, Luciana Eugenia
title	p53 at the crossroads between stress response signaling and tumorigenesis: From molecular mechanisms to therapeutic opportunities
title_short	p53 at the crossroads between stress response signaling and tumorigenesis: From molecular mechanisms to therapeutic opportunities
title_full	p53 at the crossroads between stress response signaling and tumorigenesis: From molecular mechanisms to therapeutic opportunities
title_fullStr	p53 at the crossroads between stress response signaling and tumorigenesis: From molecular mechanisms to therapeutic opportunities
title_full_unstemmed	p53 at the crossroads between stress response signaling and tumorigenesis: From molecular mechanisms to therapeutic opportunities
title_sort	p53 at the crossroads between stress response signaling and tumorigenesis: from molecular mechanisms to therapeutic opportunities
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97894017_v_n_p51_Giono http://hdl.handle.net/20.500.12110/paper_97894017_v_n_p51_Giono
work_keys_str_mv	AT gionolucianaeugenia p53atthecrossroadsbetweenstressresponsesignalingandtumorigenesisfrommolecularmechanismstotherapeuticopportunities AT ladelfamariafatima p53atthecrossroadsbetweenstressresponsesignalingandtumorigenesisfrommolecularmechanismstotherapeuticopportunities
_version_	1769175809892810752

p53 at the crossroads between stress response signaling and tumorigenesis: From molecular mechanisms to therapeutic opportunities

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