NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction
Some decades ago it was postulated that gene expression regulation is required for long-term memory storage. In the last years, important progress has been made towards the characterization of these mechanisms of transcription. Among them, transcription factors play a key role. This chapter describe...
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816080_v_n_p97_Romano http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p97_Romano |
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paper:paper_97816080_v_n_p97_Romano2023-06-08T16:38:12Z NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction ΚB decoy Consolidation Extinction Gene expression IKK Long-term memory NF-κB Reconsolidation Sulfasalazine Transcription factors Some decades ago it was postulated that gene expression regulation is required for long-term memory storage. In the last years, important progress has been made towards the characterization of these mechanisms of transcription. Among them, transcription factors play a key role. This chapter describes the characteristics and the role of one of these transcription factors, NF-κB, in the different phases of memory formation and processing. In more than a decade of research since the first data on the role of NF-κB in neuronal plasticity and memory, a growing body of evidence supports that this transcription factor is involved not only in the formation of the initial long-term memory traces but in the re-stabilization after memory reactivation induced by retrieval. Additionally, the role of NF-κB in the formation of memory extinction is now under study. Extinction entails a temporary inhibition of memory expression and entails a new memory process. Recent data support the inhibition of NF-κB in the formation of memory extinction. Here I propose the use of this transcription factor, together with other neuroplasticity-associated molecular mechanisms, as important tools for understanding the dynamics of the different phases of information processing as well as the determination of brain areas involved in such processes. Keywords: Long-term memory, consolidation, reconsolidation, extinction, gene expression, transcription factors, NF-kB, IKK, kB decoy, sulfasalazine. © 2012 Bentham Science Publishers. All rights reserved. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816080_v_n_p97_Romano http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p97_Romano |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
ΚB decoy Consolidation Extinction Gene expression IKK Long-term memory NF-κB Reconsolidation Sulfasalazine Transcription factors |
spellingShingle |
ΚB decoy Consolidation Extinction Gene expression IKK Long-term memory NF-κB Reconsolidation Sulfasalazine Transcription factors NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction |
topic_facet |
ΚB decoy Consolidation Extinction Gene expression IKK Long-term memory NF-κB Reconsolidation Sulfasalazine Transcription factors |
description |
Some decades ago it was postulated that gene expression regulation is required for long-term memory storage. In the last years, important progress has been made towards the characterization of these mechanisms of transcription. Among them, transcription factors play a key role. This chapter describes the characteristics and the role of one of these transcription factors, NF-κB, in the different phases of memory formation and processing. In more than a decade of research since the first data on the role of NF-κB in neuronal plasticity and memory, a growing body of evidence supports that this transcription factor is involved not only in the formation of the initial long-term memory traces but in the re-stabilization after memory reactivation induced by retrieval. Additionally, the role of NF-κB in the formation of memory extinction is now under study. Extinction entails a temporary inhibition of memory expression and entails a new memory process. Recent data support the inhibition of NF-κB in the formation of memory extinction. Here I propose the use of this transcription factor, together with other neuroplasticity-associated molecular mechanisms, as important tools for understanding the dynamics of the different phases of information processing as well as the determination of brain areas involved in such processes. Keywords: Long-term memory, consolidation, reconsolidation, extinction, gene expression, transcription factors, NF-kB, IKK, kB decoy, sulfasalazine. © 2012 Bentham Science Publishers. All rights reserved. |
title |
NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction |
title_short |
NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction |
title_full |
NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction |
title_fullStr |
NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction |
title_full_unstemmed |
NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction |
title_sort |
nf-κb transcription factor: a model for the study of transcription regulation in memory consolidation, reconsolidation and extinction |
publishDate |
2012 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816080_v_n_p97_Romano http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p97_Romano |
_version_ |
1768542862049280000 |