How to Find an HNO Needle in a (Bio)-Chemical Haystack

Azanone (also called nitroxyl or simply HNO) is an intrinsic elusive molecule, with a proven history of chemically and biologically relevant reactivity. The chapter describes many HNO donors, potential HNO production reactions, and azanone potential biological effects. Azanone donors are based mainl...

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Detalles Bibliográficos
Publicado: 2014
Materias:
Azanone
Biochemical reactions
Chemical reactions
HNO releasing agents
Real-time detection method
Therapeutic compounds
Trapping method
Amines
Reaction kinetics
Signal detection
Real-time detection
Releasing agent
Trapping methods
Chemical detection
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97811187_v58_n_p145_Doctorovich
http://hdl.handle.net/20.500.12110/paper_97811187_v58_n_p145_Doctorovich
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_97811187_v58_n_p145_Doctorovich
record_format dspace
spelling paper:paper_97811187_v58_n_p145_Doctorovich2023-06-08T16:37:12Z How to Find an HNO Needle in a (Bio)-Chemical Haystack Azanone Biochemical reactions Chemical reactions HNO releasing agents Real-time detection method Therapeutic compounds Trapping method Amines Chemical reactions Reaction kinetics Signal detection Azanone Biochemical reactions Real-time detection Releasing agent Therapeutic compounds Trapping methods Chemical detection Azanone (also called nitroxyl or simply HNO) is an intrinsic elusive molecule, with a proven history of chemically and biologically relevant reactivity. The chapter describes many HNO donors, potential HNO production reactions, and azanone potential biological effects. Azanone donors are based mainly on hydroxylamine and its derivatives, NONOates, and C-nitroso compounds. HNO releasing agents have interesting perspectives as potential therapeutic compounds. However, more work, where HNO detections methods are critical, is needed to understand the chemical mechanisms underlying the observed physiological effects. Quantification of HNO is challenging because it is a very reactive species with a high rate for dimerization. Two different methodologies, trapping and real-time detection methods, have been explored in order to quantify HNO. The chapter reviews the recent advances in both types of azanone detection methods. © 2014 by John Wiley & Sons, Inc. All rights reserved. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97811187_v58_n_p145_Doctorovich http://hdl.handle.net/20.500.12110/paper_97811187_v58_n_p145_Doctorovich
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Azanone
Biochemical reactions
Chemical reactions
HNO releasing agents
Real-time detection method
Therapeutic compounds
Trapping method
Amines
Chemical reactions
Reaction kinetics
Signal detection
Azanone
Biochemical reactions
Real-time detection
Releasing agent
Therapeutic compounds
Trapping methods
Chemical detection
spellingShingle Azanone
Biochemical reactions
Chemical reactions
HNO releasing agents
Real-time detection method
Therapeutic compounds
Trapping method
Amines
Chemical reactions
Reaction kinetics
Signal detection
Azanone
Biochemical reactions
Real-time detection
Releasing agent
Therapeutic compounds
Trapping methods
Chemical detection
How to Find an HNO Needle in a (Bio)-Chemical Haystack
topic_facet Azanone
Biochemical reactions
Chemical reactions
HNO releasing agents
Real-time detection method
Therapeutic compounds
Trapping method
Amines
Chemical reactions
Reaction kinetics
Signal detection
Azanone
Biochemical reactions
Real-time detection
Releasing agent
Therapeutic compounds
Trapping methods
Chemical detection
description Azanone (also called nitroxyl or simply HNO) is an intrinsic elusive molecule, with a proven history of chemically and biologically relevant reactivity. The chapter describes many HNO donors, potential HNO production reactions, and azanone potential biological effects. Azanone donors are based mainly on hydroxylamine and its derivatives, NONOates, and C-nitroso compounds. HNO releasing agents have interesting perspectives as potential therapeutic compounds. However, more work, where HNO detections methods are critical, is needed to understand the chemical mechanisms underlying the observed physiological effects. Quantification of HNO is challenging because it is a very reactive species with a high rate for dimerization. Two different methodologies, trapping and real-time detection methods, have been explored in order to quantify HNO. The chapter reviews the recent advances in both types of azanone detection methods. © 2014 by John Wiley & Sons, Inc. All rights reserved.
title How to Find an HNO Needle in a (Bio)-Chemical Haystack
title_short How to Find an HNO Needle in a (Bio)-Chemical Haystack
title_full How to Find an HNO Needle in a (Bio)-Chemical Haystack
title_fullStr How to Find an HNO Needle in a (Bio)-Chemical Haystack
title_full_unstemmed How to Find an HNO Needle in a (Bio)-Chemical Haystack
title_sort how to find an hno needle in a (bio)-chemical haystack
publishDate 2014
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97811187_v58_n_p145_Doctorovich
http://hdl.handle.net/20.500.12110/paper_97811187_v58_n_p145_Doctorovich
_version_ 1768546277640896512

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