Interplay Between Chromatin and Splicing

Alternative splicing is a fundamental mRNA processing event that explains how a high biologic complexity is achieved from a limited number of genes. By allowing each gene to encode several polypeptide variants, alternative splicing largely expands the coding capacities of the genetic information. Re...

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Detalles Bibliográficos
Publicado: 2016
Materias:
Alternative splicing
Chromatin structure
RNAPII elongation rate
Transcription
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97801280_v_n_p191_Fiszbein
http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p191_Fiszbein
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_97801280_v_n_p191_Fiszbein
record_format dspace
spelling paper:paper_97801280_v_n_p191_Fiszbein2023-06-08T16:37:00Z Interplay Between Chromatin and Splicing Alternative splicing Chromatin structure RNAPII elongation rate Transcription Alternative splicing is a fundamental mRNA processing event that explains how a high biologic complexity is achieved from a limited number of genes. By allowing each gene to encode several polypeptide variants, alternative splicing largely expands the coding capacities of the genetic information. Regulation of splicing and alternative splicing is important to determine normal cell functioning, cell differentiation, and responses to external cues. Moreover, misregulation of splicing is frequently associated to hereditary disease and cancer. As most splicing or splicing commitment takes place cotranscriptionally, an additional layer of splicing regulation based on the regulation of transcription is opened. As transcription occurs through chromatin, any particular factor affecting chromatin structure will also alter transcription and therefore may eventually affect splicing decisions. A complex picture emerges in which splicing regulation not only depends on chromatin structure determined by specific histone marks, but also by DNA methylation and nucleosome positioning. Moreover, in actively transcribed genes, transcription and alternative splicing machineries, and dynamics affect chromatin structure. This chapter discusses the multiple layers of cotranscriptional regulation of splicing and alternative splicing in which chromatin structure plays a fundamental role by providing a dynamic scaffold for interactions between the splicing and transcription machineries. We focus on evidence that explains how chromatin organization can impact on the regulation of splicing and alternative splicing acting in coordination with recruitment of splicing factors, adaptor proteins, and cotranscriptional features. © 2017 Elsevier Inc. All rights reserved. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97801280_v_n_p191_Fiszbein http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p191_Fiszbein
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Alternative splicing
Chromatin structure
RNAPII elongation rate
Transcription
spellingShingle Alternative splicing
Chromatin structure
RNAPII elongation rate
Transcription
Interplay Between Chromatin and Splicing
topic_facet Alternative splicing
Chromatin structure
RNAPII elongation rate
Transcription
description Alternative splicing is a fundamental mRNA processing event that explains how a high biologic complexity is achieved from a limited number of genes. By allowing each gene to encode several polypeptide variants, alternative splicing largely expands the coding capacities of the genetic information. Regulation of splicing and alternative splicing is important to determine normal cell functioning, cell differentiation, and responses to external cues. Moreover, misregulation of splicing is frequently associated to hereditary disease and cancer. As most splicing or splicing commitment takes place cotranscriptionally, an additional layer of splicing regulation based on the regulation of transcription is opened. As transcription occurs through chromatin, any particular factor affecting chromatin structure will also alter transcription and therefore may eventually affect splicing decisions. A complex picture emerges in which splicing regulation not only depends on chromatin structure determined by specific histone marks, but also by DNA methylation and nucleosome positioning. Moreover, in actively transcribed genes, transcription and alternative splicing machineries, and dynamics affect chromatin structure. This chapter discusses the multiple layers of cotranscriptional regulation of splicing and alternative splicing in which chromatin structure plays a fundamental role by providing a dynamic scaffold for interactions between the splicing and transcription machineries. We focus on evidence that explains how chromatin organization can impact on the regulation of splicing and alternative splicing acting in coordination with recruitment of splicing factors, adaptor proteins, and cotranscriptional features. © 2017 Elsevier Inc. All rights reserved.
title Interplay Between Chromatin and Splicing
title_short Interplay Between Chromatin and Splicing
title_full Interplay Between Chromatin and Splicing
title_fullStr Interplay Between Chromatin and Splicing
title_full_unstemmed Interplay Between Chromatin and Splicing
title_sort interplay between chromatin and splicing
publishDate 2016
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97801280_v_n_p191_Fiszbein
http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p191_Fiszbein
_version_ 1768543776145408000

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