Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation

The neural cell adhesion molecule (NCAM; CD56) is a member of the immunoglobulin protein superfamily. It has been described as a key molecule for the regulation of neuronal differentiation, synaptogenesis, memory formation, and neuronal plasticity. Alternative splicing gives rise to at least 20-30 N...

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Autores principales:	Fiszbein, Ana, Schor, Ignacio Esteban, Kornblihtt, Alberto Rodolfo
Publicado:	2015
Materias:	Alternative splicing CD56 Chromatin structure NCAM Neuronal differentiation Transcription rate Cell adhesion Chromosomes Molecules Neurons
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97801280_v_n_p131_Fiszbein http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p131_Fiszbein
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_97801280_v_n_p131_Fiszbein
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spelling	paper:paper_97801280_v_n_p131_Fiszbein2023-06-08T16:36:59Z Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation Fiszbein, Ana Schor, Ignacio Esteban Kornblihtt, Alberto Rodolfo Alternative splicing CD56 Chromatin structure NCAM Neuronal differentiation Transcription rate Cell adhesion Chromosomes Molecules Alternative splicing CD56 Chromatin structure NCAM Neuronal differentiation Neurons The neural cell adhesion molecule (NCAM; CD56) is a member of the immunoglobulin protein superfamily. It has been described as a key molecule for the regulation of neuronal differentiation, synaptogenesis, memory formation, and neuronal plasticity. Alternative splicing gives rise to at least 20-30 NCAM isoforms in mice and humans, NCAM120, NCAM140, and NCAM180 being the more abundant. There are many different modes of alternative splicing; the difference between NCAM140 and NCAM180 is the inclusion or exclusion of an alternative exon. During neuronal differentiation, the alternative splicing pattern of NCAM changes, favoring the expression of NCAM180 to the detriment of NCAM140. In this work we review the most relevant information about NCAM structure and function and present the molecular basis of alternative splicing and its regulation with particular emphasis on how changes in chromatin structure are key for the regulation of NCAM splicing during neuronal differentiation and upon membrane depolarization. © 2015 Elsevier Inc. All rights reserved. Fil:Fiszbein, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Schor, I.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97801280_v_n_p131_Fiszbein http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p131_Fiszbein
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Alternative splicing CD56 Chromatin structure NCAM Neuronal differentiation Transcription rate Cell adhesion Chromosomes Molecules Alternative splicing CD56 Chromatin structure NCAM Neuronal differentiation Neurons
spellingShingle	Alternative splicing CD56 Chromatin structure NCAM Neuronal differentiation Transcription rate Cell adhesion Chromosomes Molecules Alternative splicing CD56 Chromatin structure NCAM Neuronal differentiation Neurons Fiszbein, Ana Schor, Ignacio Esteban Kornblihtt, Alberto Rodolfo Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation
topic_facet	Alternative splicing CD56 Chromatin structure NCAM Neuronal differentiation Transcription rate Cell adhesion Chromosomes Molecules Alternative splicing CD56 Chromatin structure NCAM Neuronal differentiation Neurons
description	The neural cell adhesion molecule (NCAM; CD56) is a member of the immunoglobulin protein superfamily. It has been described as a key molecule for the regulation of neuronal differentiation, synaptogenesis, memory formation, and neuronal plasticity. Alternative splicing gives rise to at least 20-30 NCAM isoforms in mice and humans, NCAM120, NCAM140, and NCAM180 being the more abundant. There are many different modes of alternative splicing; the difference between NCAM140 and NCAM180 is the inclusion or exclusion of an alternative exon. During neuronal differentiation, the alternative splicing pattern of NCAM changes, favoring the expression of NCAM180 to the detriment of NCAM140. In this work we review the most relevant information about NCAM structure and function and present the molecular basis of alternative splicing and its regulation with particular emphasis on how changes in chromatin structure are key for the regulation of NCAM splicing during neuronal differentiation and upon membrane depolarization. © 2015 Elsevier Inc. All rights reserved.
author	Fiszbein, Ana Schor, Ignacio Esteban Kornblihtt, Alberto Rodolfo
author_facet	Fiszbein, Ana Schor, Ignacio Esteban Kornblihtt, Alberto Rodolfo
author_sort	Fiszbein, Ana
title	Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation
title_short	Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation
title_full	Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation
title_fullStr	Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation
title_full_unstemmed	Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation
title_sort	fundamentals of ncam expression, function, and regulation of alternative splicing in neuronal differentiation
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97801280_v_n_p131_Fiszbein http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p131_Fiszbein
work_keys_str_mv	AT fiszbeinana fundamentalsofncamexpressionfunctionandregulationofalternativesplicinginneuronaldifferentiation AT schorignacioesteban fundamentalsofncamexpressionfunctionandregulationofalternativesplicinginneuronaldifferentiation AT kornblihttalbertorodolfo fundamentalsofncamexpressionfunctionandregulationofalternativesplicinginneuronaldifferentiation
_version_	1768544661923692544

Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation

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